HAMAP rule MF_02124
General rule information
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Accession | MF_02124 |
Dates | 29-SEP-2011 (Created)
19-NOV-2022 (Last updated, Version 12) |
Name | GlgE |
Scope(s) |
Bacteria Archaea |
Template(s) | P9WQ17 (GLGE_MYCTU); Q9L1K2 (GLGE1_STRCO); Q9RP48 (GLGE_MYCS2); Q9KY04 (GLGE2_STRCO); [ Recover all ] |
Triggered by |
HAMAP; MF_02124 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GLGE |
Protein name | RecName: Full=Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase; Short=GMPMT; EC=2.4.99.16; AltName: Full=(1->4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase; |
Gene name | Name=glgE; |
Comments
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FUNCTION | Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB. |
CATALYTIC ACTIVITY | Reaction=[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1->4)-alpha-D-glucosyl](n+2) + phosphate; Xref=Rhea:RHEA:42692, Rhea:RHEA-COMP:9584, Rhea:RHEA-COMP:10183, ChEBI:CHEBI:15444, ChEBI:CHEBI:43474, ChEBI:CHEBI:63576; EC=2.4.99.16; |
case <OC:Mycobacterium> | |
PATHWAY | Glycan biosynthesis; glycogen biosynthesis. |
end case | |
SUBUNIT | Homodimer. |
SIMILARITY | Belongs to the glycosyl hydrolase 13 family. GlgE subfamily. |
Keywords
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Carbohydrate metabolism | |
Glycosyltransferase | |
Transferase | |
case <OC:Mycobacterium> | |
Glycogen biosynthesis | |
Glycogen metabolism | |
end case |
Gene Ontology
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GO:0016758; Molecular function:hexosyltransferase activity | |
GO:0030979; Biological process:alpha-glucan biosynthetic process | |
case <OCellular component:Mycobacterium> | |
GO:0005978; Biological process:glycogen biosynthetic process | |
end case |
Cross-references
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Features
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From: GLGE1_STRCO (Q9L1K2) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 534 | 535 | /ligand="alpha-maltose 1-phosphate" /ligand_id="ChEBI:CHEBI:63576" |
K-[YF] | ||||||||
ACT_SITE | 394 | 394 | /note="Nucleophile" | D | ||||||||
ACT_SITE | 423 | 423 | /note="Proton donor" | E | ||||||||
BINDING | 264 | 264 | /ligand="alpha-maltose 1-phosphate" /ligand_id="ChEBI:CHEBI:63576" |
[KR] | ||||||||
BINDING | 324 | 324 | /ligand="alpha-maltose 1-phosphate" /ligand_id="ChEBI:CHEBI:63576" |
Q | ||||||||
BINDING | 359 | 359 | /ligand="alpha-maltose 1-phosphate" /ligand_id="ChEBI:CHEBI:63576" |
D | ||||||||
BINDING | 395 | 395 | /ligand="alpha-maltose 1-phosphate" /ligand_id="ChEBI:CHEBI:63576" |
N | ||||||||
SITE | 480 | 480 | /note="Transition state stabilizer" | D |
Additional information
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Size range | 630-746 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | The "GlgE pathway" has been shown to be involved in the conversion of trehalosee to glycogen in M.smegmatis (see PubMed=18505459), but it may be also involved in the biosynthesis of other types of alpha(1->4)-glucans. |