HAMAP rule MF_02124
General rule information
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Accession | MF_02124 |
Dates | 29-SEP-2011 (Created) 19-NOV-2022 (Last updated, Version 12) |
Name | GlgE |
Scope | Bacteria
Archaea |
Templates | P9WQ17 (GLGE_MYCTU); Q9L1K2 (GLGE1_STRCO); Q9RP48 (GLGE_MYCS2); Q9KY04 (GLGE2_STRCO): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB. |
Catalytic activity | RHEA:42692: [(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1->4)-alpha-D-glucosyl](n+2) + phosphate
EC 2.4.99.16 |
case <OC:Mycobacterium>
Pathway | Glycan biosynthesis; glycogen biosynthesis. |
end case
Subunit | Homodimer. |
Similarity | Belongs to the glycosyl hydrolase 13 family. GlgE subfamily. |
Keywords
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case <OC:Mycobacterium>
end case
Gene Ontology
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GO:0016758; Molecular function: hexosyltransferase activity.
GO:0030979; Biological process: alpha-glucan biosynthetic process.
GO:0030979; Biological process: alpha-glucan biosynthetic process.
case <OC:Mycobacterium>
GO:0005978; Biological process: glycogen biosynthetic process.
end case
Cross-references
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Features
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From: GLGE1_STRCO (Q9L1K2) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 534 | 535 | /ligand="alpha-maltose 1-phosphate" /ligand_id="ChEBI:CHEBI:63576 | K-[YF] | ||||||||
ACT_SITE | 394 | 394 | Nucleophile | D | ||||||||
ACT_SITE | 423 | 423 | Proton donor | E | ||||||||
BINDING | 264 | 264 | /ligand="alpha-maltose 1-phosphate" /ligand_id="ChEBI:CHEBI:63576 | [KR] | ||||||||
BINDING | 324 | 324 | /ligand="alpha-maltose 1-phosphate" /ligand_id="ChEBI:CHEBI:63576 | Q | ||||||||
BINDING | 359 | 359 | /ligand="alpha-maltose 1-phosphate" /ligand_id="ChEBI:CHEBI:63576 | D | ||||||||
BINDING | 395 | 395 | /ligand="alpha-maltose 1-phosphate" /ligand_id="ChEBI:CHEBI:63576 | N | ||||||||
SITE | 480 | 480 | Transition state stabilizer | D |
Additional information
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Size range | 630-746 amino acids |
Related rules | None |
Fusion | None |
Comments | The "GlgE pathway" has been shown to be involved in the conversion of trehalosee to glycogen in M.smegmatis (see PubMed=18505459), but it may be also involved in the biosynthesis of other types of alpha(1->4)-glucans. |