HAMAP rule MF_02127
General rule information
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Accession | MF_02127 |
Dates | 21-NOV-2011 (Created) 19-NOV-2022 (Last updated, Version 12) |
Name | Glucose_DH |
Scope | Archaea |
Templates | O93715 (GLCDH_SACSO); Q977U7 (GLCDH_HALMT); Q6L047 (GLCD2_PICTO); P13203 (GLCDH_THEAC); Q703W7 (GLCDH_THETK): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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case <OC:Halobacteria>
Function | Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway. |
else
Function | Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway. |
end case
Catalytic activity | RHEA:14293: D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH
EC 1.1.1.47 |
RHEA:14405: D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH
EC 1.1.1.47 |
case <FTGroup:1> and <FTGroup:2>
Cofactor | Zn(2+) Note: Binds 2 Zn(2+) ions per subunit. One of the zinc atoms is essential for catalytic activity while the other has a structural function. |
else
Cofactor | Zn(2+) |
end case
Similarity | Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily. |
Keywords
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Gene Ontology
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GO:0005536; Molecular function: glucose binding.
GO:0047936; Molecular function: glucose 1-dehydrogenase [NAD(P)] activity.
GO:0070401; Molecular function: NADP+ binding.
GO:0070403; Molecular function: NAD+ binding.
GO:0008270; Molecular function: zinc ion binding.
GO:0019595; Biological process: non-phosphorylated glucose catabolic process.
GO:0047936; Molecular function: glucose 1-dehydrogenase [NAD(P)] activity.
GO:0070401; Molecular function: NADP+ binding.
GO:0070403; Molecular function: NAD+ binding.
GO:0008270; Molecular function: zinc ion binding.
GO:0019595; Biological process: non-phosphorylated glucose catabolic process.
Cross-references
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Features
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From: GLCDH_SACSO (O93715) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 189 | 192 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | [TNSA]-x-x-[ILV] | ||||||||
BINDING (Optional) | 211 | 213 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | N-x-[RH] | ||||||||
BINDING (Optional) | 277 | 279 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | [FL]-x-[FVILT] | ||||||||
BINDING | 305 | 307 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | [LSTAV]-x-[ND] | ||||||||
BINDING | 41 | 41 | /ligand="substrate | [TS] | ||||||||
BINDING (Optional) | 89 | 89 | /ligand="substrate | N | ||||||||
BINDING (Optional) | 114 | 114 | /ligand="substrate | E | ||||||||
BINDING | 150 | 150 | /ligand="substrate | [QE] | ||||||||
BINDING (Optional) | 154 | 154 | /ligand="substrate | [DN] | ||||||||
BINDING | 307 | 307 | /ligand="substrate | [ND] | ||||||||
BINDING | 39 | 39 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic | [CD] | 1 | |||||||
BINDING | 66 | 66 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 67 | 67 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic | E | 1 | |||||||
BINDING (Optional) | 93 | 93 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="structural | C | 2 | |||||||
BINDING (Optional) | 96 | 96 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="structural | C | 2 | |||||||
BINDING (Optional) | 99 | 99 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="structural | C | 2 | |||||||
BINDING (Optional) | 107 | 107 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="structural | C | 2 | |||||||
BINDING | 150 | 150 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic | [QE] | 1 | |||||||
BINDING (Optional) | 354 | 354 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | K |
case not <FT:2>
From: GLCDH_HALMT (Q977U7) | ||||||||||||
BINDING (Optional) | 207 | 208 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | R-R |
end case
Additional information
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Size range | 347-368 amino acids |
Related rules | None |
Fusion | None |
Comments | Some members of this family also display good catalytic efficiency with D-galactose as substrate (SULSF, Q6L047 in PICTO, THEAC), which seems to be a physiological substrate in some species. |