HAMAP rule MF_02129
General rule information
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| Accession | MF_02129 |
| Dates | 4-MAY-2012 (Created) 19-NOV-2022 (Last updated, Version 10) |
| Name | L_carnitine_dehydrog |
| Scope | Bacteria |
| Templates | D7URM0 (LCDH_PSESP); D7UNT2 (LCDH_RHISP); Q9HTH8 (LCDH_PSEAE): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine. |
| Catalytic activity | RHEA:19265: carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH
EC 1.1.1.108 |
| Pathway | Amine and polyamine metabolism; carnitine metabolism. |
| Subunit | Homodimer. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily. |
Keywords
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Gene Ontology
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GO:0047728; Molecular function: carnitine 3-dehydrogenase activity.
GO:0051287; Molecular function: NAD binding.
GO:0042413; Biological process: carnitine catabolic process.
GO:0005737; Cellular component: cytoplasm.
GO:0051287; Molecular function: NAD binding.
GO:0042413; Biological process: carnitine catabolic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF00725; 3HCDH; 1; |
| PF02737; 3HCDH_N; 1; | |
| PIRSF | PIRSF000105; HCDH; 1; |
Features
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| From: LCDH_PSESP (D7URM0) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 14 | 19 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | G-x-G-x-x-G | ||||||||
Additional information
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| Size range | 307-364 amino acids |
| Related rules | None |
| Fusion | Nter: None; Cter: <Unknown> |
| Comments | See Uanschou et al. Monatshefte f?r Chemie 136, 1365?1381 (2005), (http://www.springerlink.com/content/kn5531797l238128/fulltext.pdf) for a comparative genomic sequence analysis of L-carnitine dehydrogenase. RHILO possesses a longer C-terminus very rich in lysine residues. |