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Annotation rule MF_02129
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General rule information [?]

Accession MF_02129
Dates 4-MAY-2012 (Created)
20-NOV-2019 (Last updated, Version 8)
Name L_carnitine_dehydrog
Scope
Bacteria
Templates D7URM0 (LCDH_PSESP); D7UNT2 (LCDH_RHISP); Q9HTH8 (LCDH_PSEAE): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LCDH
Protein name
RecName: Full=L-carnitine dehydrogenase;
Short=L-CDH;
Short=CDH;
EC 1.1.1.108;
Gene name
lcdH

Comments [?]

Function Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.
Catalytic activity RHEA:19265: carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH
EC 1.1.1.108
Pathway Amine and polyamine metabolism; carnitine metabolism.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0047728; Molecular function: carnitine 3-dehydrogenase activity.
GO:0051287; Molecular function: NAD binding.
GO:0042413; Biological process: carnitine catabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00725; 3HCDH; 1;
PF02737; 3HCDH_N; 1;
PIRSF PIRSF000105; HCDH; 1;

Features [?]

From: LCDH_PSESP (D7URM0)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     14     19       NAD     G-x-G-x-x-G  

Additional information [?]

Size range 307-364 amino acids
Related rules None
Fusion Nter: None; Cter: <Unknown>
Comments See Uanschou et al. Monatshefte f?r Chemie 136, 1365?1381 (2005), (http://www.springerlink.com/content/kn5531797l238128/fulltext.pdf) for a comparative genomic sequence analysis of L-carnitine dehydrogenase. RHILO possesses a longer C-terminus very rich in lysine residues.