HAMAP rule MF_02209

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_02209
Accession	MF_02209
Dates	23-JAN-2019 (Created) 02-SEP-2024 (Last updated, Version 5)
Name	MurL
Scope(s)	Bacteria
Template(s)	P0DQD8; C4RJF8; A4X982; [ Recover all ]
Triggered by	HAMAP; MF_02209 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MURL
Protein name	RecName: Full=UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase; EC=5.1.1.23; AltName: Full=UDP-MurNAc-L-Ala-L-Glu epimerase;
Gene name	Name=murL;

Comments [?]

FUNCTION	Cell wall formation. Catalyzes epimerization of the terminal L-glutamate in UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate.
CATALYTIC ACTIVITY	Reaction=UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate + ATP + H2O = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + AMP + diphosphate + H(+); Xref=Rhea:RHEA:58812, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:83900, ChEBI:CHEBI:142725, ChEBI:CHEBI:456215; EC=5.1.1.23;
PATHWAY	Cell wall biogenesis; peptidoglycan biosynthesis.
SIMILARITY	Belongs to the MurL family.

Keywords [?]

Gene Ontology [?]

GO:0016855; Molecular function:racemase and epimerase activity, acting on amino acids and derivatives

GO:0009252; Biological process:peptidoglycan biosynthetic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]