HAMAP rule MF_02209
General rule information
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Accession | MF_02209 |
Dates | 23-JAN-2019 (Created)
20-NOV-2019 (Last updated, Version 3) |
Name | MurL |
Scope(s) |
Bacteria |
Template(s) | P0DQD8 (MURL_XANOM); C4RJF8 (MURL_MICS3); A4X982 (MURL_SALTO); [ Recover all ] |
Triggered by |
HAMAP; MF_02209 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MURL |
Protein name | RecName: Full=UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase; EC=5.1.1.23; AltName: Full=UDP-MurNAc-L-Ala-L-Glu epimerase; |
Gene name | Name=murL; |
Comments
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FUNCTION | Cell wall formation. Catalyzes epimerization of the terminal L-glutamate in UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate. |
CATALYTIC ACTIVITY | Reaction=ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate = AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl- D-glutamate; Xref=Rhea:RHEA:58812, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:83900, ChEBI:CHEBI:142725, ChEBI:CHEBI:456215; EC=5.1.1.23; |
PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. |
SIMILARITY | Belongs to the MurL family. |
Keywords
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Cell cycle |
Cell division |
Cell shape |
Cell wall biogenesis/degradation |
Isomerase |
Peptidoglycan synthesis |
Gene Ontology
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GO:0016855; Molecular function:racemase and epimerase activity, acting on amino acids and derivatives |
GO:0009252; Biological process:peptidoglycan biosynthetic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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Additional information
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Size range | 400-530 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |