HAMAP rule MF_02219

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_02219
Accession	MF_02219
Dates	28-JUN-2019 (Created) 28-NOV-2023 (Last updated, Version 5)
Name	Type_III_secretin
Scope(s)	Bacteria
Template(s)	Q01244; P35672; Q04641; D0ZWR9; [ Recover all ]
Triggered by	HAMAP; MF_02219 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SCTC
Protein name	RecName: Full=Type 3 secretion system secretin; Short=T3SS secretin; Flags: Precursor;
Gene name	Name=sctC;

Comments [?]

FUNCTION	Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane.
SUBUNIT	The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle. This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope. Forms a stable homooligomeric complex.
SUBCELLULAR LOCATION	Cell outer membrane.
SIMILARITY	Belongs to the bacterial secretin family. T3SS SctC subfamily.

Keywords [?]

Gene Ontology [?]

GO:0030254; Biological process:protein secretion by the type III secretion system

GO:0030257; Cellular component:type III protein secretion system complex

GO:0009279; Cellular component:cell outer membrane

Cross-references [?]

Features [?]

Additional information [?]

Size range	460-730 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	A widely accepted unified nomenclature has been proposed for the components of the type III secretion system. Genes are called sct, for secretion and cellular translocation. See Hueck C.J. (PubMed:9618447, 1998) and t3sswiki.science.