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HAMAP rule MF_02219

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General rule information [?]

Accession MF_02219
Dates 28-JUN-2019 (Created)
28-NOV-2023 (Last updated, Version 4)
Name Type_III_secretin
Scope(s) Bacteria
Template(s) Q01244 (SCTC_YEREN); P35672 (SCTC1_SALTY); Q04641 (SCTC_SHIFL); D0ZWR9 (SCTC2_SALT1); [ Recover all ]
Triggered by HAMAP; MF_02219 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SCTC
Protein name RecName: Full=Type 3 secretion system secretin;
                 Short=T3SS secretin;
                 Flags: Precursor;
Gene name Name=sctC;

Comments [?]

FUNCTIONComponent of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane.
SUBUNITThe core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle. This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope. Forms a stable homooligomeric complex.
SUBCELLULAR LOCATIONCell outer membrane.
SIMILARITYBelongs to the bacterial secretin family. T3SS SctC subfamily.

Keywords [?]

Gene Ontology [?]

GO:0030254; Biological process:protein secretion by the type III secretion system
GO:0030257; Cellular component:type III protein secretion system complex
GO:0009279; Cellular component:cell outer membrane

Cross-references [?]

PROSITE PS00875; T2SP_D; 1;
Pfam PF00263; Secretin; 1;
Pfam PF03958; Secretin_N; 2;
NCBIfam TIGR02516; type_III_yscC; 1;
General Signal; -; 1;

Features [?]

Additional information [?]

Size range 460-730 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments A widely accepted unified nomenclature has been proposed for the components of the type III secretion system. Genes are called sct, for secretion and cellular translocation. See Hueck C.J. (PubMed:9618447, 1998) and t3sswiki.science.

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