HAMAP rule MF_02219

Accession	MF_02219
Dates	28-JUN-2019 (Created) 20-NOV-2019 (Last updated, Version 2)

Name	Type_III_secretin

Scope

Bacteria

Templates

Q01244 (SCTC_YEREN); P35672 (SCTC1_SALTY); Q04641 (SCTC_SHIFL); D0ZWR9 (SCTC2_SALT1): [Recover all]

Triggered by

HAMAP; MF_02219 (Get profile general information and statistics)

Identifier

SCTC

Protein name

RecName: Full=Type 3 secretion system secretin; Short=T3SS secretin; Flags: Precursor;

Gene name

sctC

Function	Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane.
Subunit	The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle. This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope. Forms a stable homooligomeric complex.
Subcellular location	Cell outer membrane.
Similarity	Belongs to the bacterial secretin family. T3SS SctC subfamily.

Cell outer membrane
Membrane
Protein transport
Signal
Translocation
Transport

GO:0030254; Biological process: protein secretion by the type III secretion system.
GO:0030257; Cellular component: type III protein secretion system complex.
GO:0009279; Cellular component: cell outer membrane.

PROSITE	PS00875; T2SP_D; 1;
Pfam	PF00263; Secretin; 1;
	PF03958; Secretin_N; 2;
PRINTS	PR01337; TYPE3OMGPROT; 1;
TIGRFAMs	TIGR02516; type_III_yscC; 1;

General

Signal; -; 1; trigger=yes;

Size range	460-730 amino acids
Related rules	None
Fusion	None
Comments	A widely accepted unified nomenclature has been proposed for the components of the type III secretion system. Genes are called sct, for secretion and cellular translocation. See Hueck C.J. (PubMed:9618447, 1998) and t3sswiki.science.

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