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HAMAP rule MF_02219

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General rule information [?]

Accession MF_02219
Dates 28-JUN-2019 (Created)
20-NOV-2019 (Last updated, Version 2)
Name Type_III_secretin
Templates Q01244 (SCTC_YEREN); P35672 (SCTC1_SALTY); Q04641 (SCTC_SHIFL); D0ZWR9 (SCTC2_SALT1): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Type 3 secretion system secretin;
Short=T3SS secretin;
Flags: Precursor;
Gene name

Comments [?]

Function Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane.
Subunit The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle. This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope. Forms a stable homooligomeric complex.
Subcellular location Cell outer membrane.
Similarity Belongs to the bacterial secretin family. T3SS SctC subfamily.

Keywords [?]

Gene Ontology [?]

GO:0030254; Biological process: protein secretion by the type III secretion system.
GO:0030257; Cellular component: type III protein secretion system complex.
GO:0009279; Cellular component: cell outer membrane.

Cross-references [?]

PROSITE PS00875; T2SP_D; 1;
Pfam PF00263; Secretin; 1;
PF03958; Secretin_N; 2;
TIGRFAMs TIGR02516; type_III_yscC; 1;

Computed features [?]

General Signal; -; 1; trigger=yes;

Additional information [?]

Size range 460-730 amino acids
Related rules None
Fusion None
Comments A widely accepted unified nomenclature has been proposed for the components of the type III secretion system. Genes are called sct, for secretion and cellular translocation. See Hueck C.J. (PubMed:9618447, 1998) and t3sswiki.science.