HAMAP rule MF_02219
General rule information
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Accession | MF_02219 |
Dates | 28-JUN-2019 (Created)
1-JUN-2023 (Last updated, Version 3) |
Name | Type_III_secretin |
Scope(s) |
Bacteria |
Template(s) | Q01244 (SCTC_YEREN); P35672 (SCTC1_SALTY); Q04641 (SCTC_SHIFL); D0ZWR9 (SCTC2_SALT1); [ Recover all ] |
Triggered by |
HAMAP; MF_02219 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | SCTC |
Protein name | RecName: Full=Type 3 secretion system secretin; Short=T3SS secretin; Flags: Precursor; |
Gene name | Name=sctC; |
Comments
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FUNCTION | Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane. |
SUBUNIT | The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle. This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope. Forms a stable homooligomeric complex. |
SUBCELLULAR LOCATION | Cell outer membrane. |
SIMILARITY | Belongs to the bacterial secretin family. T3SS SctC subfamily. |
Keywords
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Gene Ontology
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GO:0030254; Biological process:protein secretion by the type III secretion system |
GO:0030257; Cellular component:type III protein secretion system complex |
GO:0009279; Cellular component:cell outer membrane |
Cross-references
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PROSITE | PS00875; T2SP_D; 1; |
Pfam | PF00263; Secretin; 1; |
Pfam | PF03958; Secretin_N; 2; |
PRINTS | PR01337; TYPE3OMGPROT; 1; |
NCBIfam | TIGR02516; type_III_yscC; 1; |
General | Signal; -; 1; |
Features
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Additional information
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Size range | 460-730 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | A widely accepted unified nomenclature has been proposed for the components of the type III secretion system. Genes are called sct, for secretion and cellular translocation. See Hueck C.J. (PubMed:9618447, 1998) and t3sswiki.science. |