HAMAP rule MF_02230

General rule information [?]

Accession	MF_02230
Dates	25-SEP-2019 (Created) 14-MAY-2022 (Last updated, Version 4)

Name	R15P_isomerase

Scope

Archaea

Template

Q5JFM9 (R15PI_THEKO)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

R15PI

Protein name

RecName:		Full=Ribose 1,5-bisphosphate isomerase;
		Short=R15P isomerase;
		Short=R15Pi;
		EC 5.3.1.29;
AltName:		Full=Ribulose 1,5-bisphosphate synthase;
		Short=RuBP synthase;

Comments [?]

Function	Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
Catalytic activity	RHEA:32243: alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate EC 5.3.1.29
Miscellaneous	Reaction proceeds via a cis-phosphoenolate intermediate.
Similarity	Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0043917; Molecular function: ribose 1,5-bisphosphate isomerase activity.
GO:0019323; Biological process: pentose catabolic process.

Cross-references [?]

Features [?]

From: R15PI_THEKO (Q5JFM9)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 20 23 /ligand="substrate R-G-A-[GA]

BINDING (Optional) 135 137 /ligand="substrate S-K-A

BINDING (Optional) 212 213 /ligand="substrate N-K

ACT_SITE 133 133 Proton acceptor C

ACT_SITE 202 202 Proton donor D

BINDING (Optional) 63 63 /ligand="substrate R

BINDING (Optional) 238 238 /ligand="substrate K

Additional information [?]