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HAMAP rule MF_02230

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General rule information [?]

Accession MF_02230
Dates 25-SEP-2019 (Created)
9-NOV-2023 (Last updated, Version 6)
Name R15P_isomerase
Scope(s) Archaea
Template(s) Q5JFM9 (R15PI_THEKO); D2RW80 (R15PI_HALTV); [ Recover all ]
Triggered by HAMAP; MF_02230 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier R15PI
Protein name RecName: Full=Ribose 1,5-bisphosphate isomerase;
                 Short=R15P isomerase;
                 Short=R15Pi;
                 EC=5.3.1.29;
AltName: Full=Ribulose 1,5-bisphosphate synthase;
                 Short=RuBP synthase;

Comments [?]

case <OC:Halobacteria>
FUNCTIONCatalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP).
else
FUNCTIONCatalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
end case
CATALYTIC ACTIVITY Reaction=alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate; Xref=Rhea:RHEA:32243, ChEBI:CHEBI:57870, ChEBI:CHEBI:68688; EC=5.3.1.29;
MISCELLANEOUSReaction proceeds via a cis-phosphoenolate intermediate.
SIMILARITYBelongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0043917; Molecular function:ribose 1,5-bisphosphate isomerase activity
GO:0019323; Biological process:pentose catabolic process

Cross-references [?]

Pfam PF01008; IF-2B; 1;
NCBIfam TIGR00524; eIF-2B_rel; 1;
NCBIfam TIGR00511; ribulose_e2b2; 1;

Features [?]

From: R15PI_THEKO (Q5JFM9)
Key From To Description Tag Condition FTGroup
BINDING 20 23 /ligand="substrate" R-G-A-[GA]
BINDING 135 137 /ligand="substrate" S-K-A
BINDING 212 213 /ligand="substrate" N-K
ACT_SITE 133 133 /note="Proton acceptor" C
ACT_SITE 202 202 /note="Proton donor" D
BINDING 63 63 /ligand="substrate" R
BINDING 238 238 /ligand="substrate" K

Additional information [?]

Size range 300-370 amino acids
Related rules None
Fusion Nter: None Cter: None



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