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HAMAP rule MF_02230

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General rule information [?]

Accession MF_02230
Dates 25-SEP-2019 (Created)
14-MAY-2022 (Last updated, Version 4)
Name R15P_isomerase
Template Q5JFM9 (R15PI_THEKO)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Ribose 1,5-bisphosphate isomerase;
Short=R15P isomerase;
AltName: Full=Ribulose 1,5-bisphosphate synthase;
Short=RuBP synthase;

Comments [?]

Function Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
Catalytic activity RHEA:32243: alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate
Miscellaneous Reaction proceeds via a cis-phosphoenolate intermediate.
Similarity Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0043917; Molecular function: ribose 1,5-bisphosphate isomerase activity.
GO:0019323; Biological process: pentose catabolic process.

Cross-references [?]

Pfam PF01008; IF-2B; 1;
TIGRFAMs TIGR00524; eIF-2B_rel; 1;
TIGR00511; ribulose_e2b2; 1;

Features [?]

From: R15PI_THEKO (Q5JFM9)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     20     23       /ligand="substrate     R-G-A-[GA]  
BINDING (Optional)     135     137       /ligand="substrate     S-K-A  
BINDING (Optional)     212     213       /ligand="substrate     N-K  
ACT_SITE     133     133       Proton acceptor     C  
ACT_SITE     202     202       Proton donor     D  
BINDING (Optional)     63     63       /ligand="substrate     R  
BINDING (Optional)     238     238       /ligand="substrate     K  

Additional information [?]

Size range 300-370 amino acids
Related rules None
Fusion None