HAMAP rule MF_02230
General rule information
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Accession | MF_02230 |
Dates | 25-SEP-2019 (Created) 14-MAY-2022 (Last updated, Version 4) |
Name | R15P_isomerase |
Scope | Archaea |
Template | Q5JFM9 (R15PI_THEKO) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Comments
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Function | Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO. |
Catalytic activity | RHEA:32243: alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate
EC 5.3.1.29 |
Miscellaneous | Reaction proceeds via a cis-phosphoenolate intermediate. |
Similarity | Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily. |
Keywords
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Gene Ontology
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GO:0043917; Molecular function: ribose 1,5-bisphosphate isomerase activity.
GO:0019323; Biological process: pentose catabolic process.
GO:0019323; Biological process: pentose catabolic process.
Cross-references
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Features
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From: R15PI_THEKO (Q5JFM9) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 20 | 23 | /ligand="substrate | R-G-A-[GA] | ||||||||
BINDING (Optional) | 135 | 137 | /ligand="substrate | S-K-A | ||||||||
BINDING (Optional) | 212 | 213 | /ligand="substrate | N-K | ||||||||
ACT_SITE | 133 | 133 | Proton acceptor | C | ||||||||
ACT_SITE | 202 | 202 | Proton donor | D | ||||||||
BINDING (Optional) | 63 | 63 | /ligand="substrate | R | ||||||||
BINDING (Optional) | 238 | 238 | /ligand="substrate | K |
Additional information
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Size range | 300-370 amino acids |
Related rules | None |
Fusion | None |