HAMAP rule MF_02230
General rule information
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| Accession | MF_02230 |
| Dates | 25-SEP-2019 (Created)
9-NOV-2023 (Last updated, Version 6) |
| Name | R15P_isomerase |
| Scope(s) |
Archaea |
| Template(s) | Q5JFM9 (R15PI_THEKO); D2RW80 (R15PI_HALTV); [ Recover all ] |
| Triggered by |
HAMAP; MF_02230 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | R15PI |
| Protein name | RecName: Full=Ribose 1,5-bisphosphate isomerase; Short=R15P isomerase; Short=R15Pi; EC=5.3.1.29; AltName: Full=Ribulose 1,5-bisphosphate synthase; Short=RuBP synthase; |
Comments
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| case <OC:Halobacteria> | |
| FUNCTION | Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP). |
| else | |
| FUNCTION | Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate; Xref=Rhea:RHEA:32243, ChEBI:CHEBI:57870, ChEBI:CHEBI:68688; EC=5.3.1.29; |
| MISCELLANEOUS | Reaction proceeds via a cis-phosphoenolate intermediate. |
| SIMILARITY | Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily. |
Keywords
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Gene Ontology
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| GO:0043917; Molecular function:ribose 1,5-bisphosphate isomerase activity |
| GO:0019323; Biological process:pentose catabolic process |
Cross-references
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Features
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| From: R15PI_THEKO (Q5JFM9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 20 | 23 | /ligand="substrate" | R-G-A-[GA] | ||||||||
| BINDING | 135 | 137 | /ligand="substrate" | S-K-A | ||||||||
| BINDING | 212 | 213 | /ligand="substrate" | N-K | ||||||||
| ACT_SITE | 133 | 133 | /note="Proton acceptor" | C | ||||||||
| ACT_SITE | 202 | 202 | /note="Proton donor" | D | ||||||||
| BINDING | 63 | 63 | /ligand="substrate" | R | ||||||||
| BINDING | 238 | 238 | /ligand="substrate" | K | ||||||||
Additional information
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| Size range | 300-370 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |