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Annotation rule MF_03003 |
General rule information
[?]
Accession |
MF_03003 |
Dates |
29-JAN-2009 (Created) 20-NOV-2019 (Last updated, Version 16) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Mammalia> or <OC:Viridiplantae>
Protein name |
RecName:
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Full=Eukaryotic translation initiation factor 3 subunit D;
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Short=eIF3d;
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AltName:
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Full=Eukaryotic translation initiation factor 3 subunit 7;
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AltName:
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Full=eIF-3-zeta;
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else case <OC:Fungi>
Protein name |
RecName:
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Full=Eukaryotic translation initiation factor 3 subunit D;
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Short=eIF3d;
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else
Protein name |
RecName:
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Full=Eukaryotic translation initiation factor 3 subunit D;
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Short=eIF3d;
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AltName:
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Full=Eukaryotic translation initiation factor 3 subunit 7;
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|
end case
case <OC:Vertebrata>
else case <OC:Caenorhabditis>
else case <OC:Drosophilidae>
end case
case <OC:Mammalia>
Function |
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. |
else
Function |
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. |
end case
case <OC:Mammalia>
Subunit |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. |
else case <OC:Vertebrata> and not <OC:Mammalia>
Subunit |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: @gn(EIF3A), @gn(EIF3B), @gn(EIF3C), @gn(EIF3D), @gn(EIF3E), @gn(EIF3F), @gn(EIF3G), @gn(EIF3H), @gn(EIF3I), @gn(EIF3J), @gn(EIF3K), @gn(EIF3L) and @gn(EIF3M). |
else case <OC:Drosophilidae>
Subunit |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. |
else
Subunit |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. |
end case
Subcellular location |
Cytoplasm. |
Domain |
The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex. |
case <OC:Mammalia>
Ptm |
Phosphorylated upon DNA damage, probably by ATM or ATR. |
end case
Similarity |
Belongs to the eIF-3 subunit D family. |
case <OC:Mammalia>
end case
GO:0003743; Molecular function: translation initiation factor activity.
GO:0003723; Molecular function: RNA binding.
GO:0098808; Molecular function: mRNA cap binding.
GO:0001732; Biological process: formation of cytoplasmic translation initiation complex.
GO:0002191; Biological process: cap-dependent translational initiation.
GO:0002183; Biological process: cytoplasmic translational initiation.
GO:0005737; Cellular component: cytoplasm.
GO:0005852; Cellular component: eukaryotic translation initiation factor 3 complex.
GO:0016282; Cellular component: eukaryotic 43S preinitiation complex.
GO:0033290; Cellular component: eukaryotic 48S preinitiation complex.
From: EIF3D_HUMAN (O15371) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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REGION
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285
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299
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RNA gate
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case <OC:Vertebrata>
COMPBIAS
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530
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547
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Asp/Glu-rich (highly acidic)
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end case
Additional information
[?]
Size range |
509-619 amino acids |
Related rules |
None |
Fusion |
None |