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Annotation rule MF_03009
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General rule information [?]

Accession MF_03009
Dates 30-JAN-2009 (Created)
20-NOV-2019 (Last updated, Version 15)
Name eIF3j
Scope
Eukaryota
Templates O75822 (EIF3J_HUMAN); Q66JS6 (EI3JB_MOUSE); Q05775 (EIF3J_YEAST): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
EIF3J
case <OC:Vertebrata>
Protein name
RecName: Full=Eukaryotic translation initiation factor 3 subunit J;
Short=eIF3j;
AltName: Full=Eukaryotic translation initiation factor 3 subunit 1;
AltName: Full=eIF-3-alpha;
AltName: Full=eIF3 p35;
else case <OC:Fungi>
Protein name
RecName: Full=Eukaryotic translation initiation factor 3 subunit J;
Short=eIF3j;
AltName: Full=Eukaryotic translation initiation factor 3 30 kDa subunit homolog;
Short=eIF-3 30 kDa subunit homolog;
else
Protein name
RecName: Full=Eukaryotic translation initiation factor 3 subunit J;
Short=eIF3j;
end case
case <OC:Vertebrata>
Gene name
EIF3J, EIF3S1
else case <OC:Drosophilidae>
Gene name
eIF3j, Adam
else case <OC:Fungi>
Gene name
HCR1
end case

Comments [?]

case <OC:Mammalia>
Function Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
else
Function Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
end case
case <OC:Mammalia>
Subunit Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
else case <OC:Vertebrata> and not <OC:Mammalia>
Subunit Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: @gn(EIF3A), @gn(EIF3B), @gn(EIF3C), @gn(EIF3D), @gn(EIF3E), @gn(EIF3F), @gn(EIF3G), @gn(EIF3H), @gn(EIF3I), @gn(EIF3J), @gn(EIF3K), @gn(EIF3L) and @gn(EIF3M).
else case <OC:Drosophilidae>
Subunit Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
else
Subunit Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
end case
Subcellular location Cytoplasm.
case <OC:Mammalia>
Ptm Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
end case
Similarity Belongs to the eIF-3 subunit J family.

Keywords [?]

Cytoplasm
Initiation factor
Protein biosynthesis
case <FTTag:acetyl>
Acetylation
end case
case <OC:Mammalia>
Phosphoprotein
end case

Gene Ontology [?]

GO:0003743; Molecular function: translation initiation factor activity.
GO:0001732; Biological process: formation of cytoplasmic translation initiation complex.
GO:0002183; Biological process: cytoplasmic translational initiation.
GO:0005737; Cellular component: cytoplasm.
GO:0005852; Cellular component: eukaryotic translation initiation factor 3 complex.
GO:0016282; Cellular component: eukaryotic 43S preinitiation complex.
GO:0033290; Cellular component: eukaryotic 48S preinitiation complex.

Cross-references [?]

Pfam PF08597; eIF3_subunit; 1;

Computed features [?]

General Coiled_coil; -; 0-unlimited; trigger=yes;

Features [?]

case <OC:Mammalia>
From: EIF3J_HUMAN (O75822)
Key     From     To       Description   Tag   Condition   FTGroup
INIT_MET     Nter     Nter       Removed        
REGION     1     69       Sufficient for interaction with EIF3B        
REGION     243     258       Promotes stable association with the 40S ribosome        
MOD_RES     Nter+1     Nter+1       N-acetylalanine   acetyl   A  
MOD_RES     11     11       Phosphoserine     S  
MOD_RES     13     13       Phosphoserine     S  
MOD_RES     20     20       Phosphoserine     S  
MOD_RES     109     109       Phosphothreonine     T  
end case

Additional information [?]

Size range 211-289 amino acids
Related rules None
Fusion None


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