Home  |  Contact
Annotation rule MF_03017
Send feedback

General rule information [?]

Accession MF_03017
Dates 12-FEB-2009 (Created)
20-NOV-2019 (Last updated, Version 13)
Name Kynureninase_euk
Scope
Eukaryota
Templates Q16719 (KYNU_HUMAN); P70712 (KYNU_RAT); Q05979 (KYNU_YEAST): [Recover all]
case <OC:Eukaryota>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KYNU
case <OC:Fungi>
Protein name
RecName: Full=Kynureninase;
EC 3.7.1.3;
AltName: Full=Biosynthesis of nicotinic acid protein 5;
AltName: Full=L-kynurenine hydrolase;
else
Protein name
RecName: Full=Kynureninase;
EC 3.7.1.3;
AltName: Full=L-kynurenine hydrolase;
end case
case <OC:Dictyostelium>
Gene name
kynu
else case <OC:Fungi>
Gene name
BNA5
else case <OC:Eukaryota> and not <OC:Arthropoda> and not <OC:Nematoda> and not <OC:Platyhelminthes>
Gene name
KYNU
end case

Comments [?]

case <OC:Mammalia>
Function Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
else
Function Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
end case
Catalytic activity RHEA:16813: H2O + L-kynurenine = anthranilate + H(+) + L-alanine
EC 3.7.1.3
RHEA:25143: 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine
case <FTTag:PLP>
end case
Pathway Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.
Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the kynureninase family.

Keywords [?]

case <FTTag:acetyl>
end case
case <FTTag:PLP>
end case

Gene Ontology [?]

GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0030429; Molecular function: kynureninase activity.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0019805; Biological process: quinolinate biosynthetic process.
GO:0034354; Biological process: 'de novo' NAD biosynthetic process from tryptophan.
GO:0043420; Biological process: anthranilate metabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00266; Aminotran_5; 1;
TIGRFAMs TIGR01814; Kynureninase; 1;

Features [?]

case <OC:Vertebrata>
From: KYNU_HUMAN (Q16719)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     1     1       N-acetylmethionine   acetyl   M  
end case
REGION     165     168       Pyridoxal phosphate binding     F-P-S-D  
BINDING     137     137       Pyridoxal phosphate; via amide nitrogen     L  
BINDING     138     138       Pyridoxal phosphate     [ST]  
BINDING (Optional)     221     221       Pyridoxal phosphate     S  
BINDING     250     250       Pyridoxal phosphate     D  
BINDING     253     253       Pyridoxal phosphate     H  
BINDING     275     275       Pyridoxal phosphate     Y  
MOD_RES     276     276       N6-(pyridoxal phosphate)lysine   PLP   K  
BINDING     305     305       Pyridoxal phosphate     W  
BINDING     333     333       Pyridoxal phosphate     [TN]  

Additional information [?]

Size range 396-539 amino acids
Related rules None
Fusion None