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Annotation rule MF_03032
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General rule information [?]

Accession MF_03032
Dates 14-APR-2009 (Created)
20-NOV-2019 (Last updated, Version 10)
Name AGO3
Scope
Eukaryota; Vertebrata
Templates Q9H9G7 (AGO3_HUMAN); Q8CJF9 (AGO3_MOUSE): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
AGO3
Protein name
RecName: Full=Protein argonaute-3;
Short=Argonaute3;
AltName: Full=Eukaryotic translation initiation factor 2C 3;
Short=eIF-2C 3;
Short=eIF2C 3;
Gene name
EIF2C3, AGO3

Comments [?]

Function Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.
case <OC:Mammalia>
Subunit Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
end case
Subcellular location Cytoplasm, P-body.
Similarity Belongs to the argonaute family. Ago subfamily.

Keywords [?]

Cytoplasm
Ribonucleoprotein
RNA-binding
RNA-mediated gene silencing
Translation regulation

Gene Ontology [?]

GO:0035198; Molecular function: miRNA binding.
GO:0035278; Biological process: miRNA mediated inhibition of translation.
GO:0016442; Cellular component: RISC complex.

Cross-references [?]

PROSITE PS50821; PAZ; 1; trigger=PRU00142;
PS50822; PIWI; 1; trigger=PRU00150;
Pfam PF08699; DUF1785; 1;
PF02170; PAZ; 1;
PF02171; Piwi; 1;

Additional information [?]

Size range 860-861 amino acids
Related rules None
Fusion None


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