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Annotation rule MF_03032 |
Accession | MF_03032 |
Dates | 14-APR-2009 (Created) 20-NOV-2019 (Last updated, Version 10) |
Name | AGO3 |
Scope | Eukaryota; Vertebrata |
Templates | Q9H9G7 (AGO3_HUMAN); Q8CJF9 (AGO3_MOUSE): [Recover all] |
Triggered by |
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Protein name |
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Gene name |
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Function | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. |
Subunit | Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H. |
Subcellular location | Cytoplasm, P-body. |
Similarity | Belongs to the argonaute family. Ago subfamily. |
PROSITE | PS50821; PAZ; 1; trigger=PRU00142; |
PS50822; PIWI; 1; trigger=PRU00150; | |
Pfam | PF08699; DUF1785; 1; |
PF02170; PAZ; 1; | |
PF02171; Piwi; 1; |
Size range | 860-861 amino acids |
Related rules | None |
Fusion | None |