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HAMAP rule MF_03065

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General rule information [?]

Accession MF_03065
Dates 23-JAN-2014 (Created)
1-JUN-2023 (Last updated, Version 10)
Name RTEL1
Scope
Eukaryota; Metazoa
Templates Q9NZ71 (RTEL1_HUMAN); Q0VGM9 (RTEL1_MOUSE); Q93575 (RTEL1_CAEEL): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RTEL1
case <OC:Vertebrata>
Protein name
RecName: Full=Regulator of telomere elongation helicase 1;
EC 3.6.4.12;
else
Protein name
RecName: Full=Regulator of telomere elongation helicase 1 homolog;
EC 3.6.4.12;
end case
case <OC:Vertebrata>
Gene name
RTEL1
else case <OC:Caenorhabditis>
Gene name
rtel-1, bch-1
end case

Comments [?]

case <OC:Vertebrata>
Function ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.
else
Function ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.
end case
Catalytic activity RHEA:13065: ATP + H2O = ADP + H(+) + phosphate
EC 3.6.4.12
case <OC:Mammalia>
Subunit Interacts with TERF1. Interacts (via PIP-box) with PCNA; the interaction is direct and essential for suppressing telomere fragility. Interacts with MMS19; the interaction mediates the association of RTEL1 with the cytosolic iron-sulfur protein assembly (CIA) complex.
end case
case <OC:Mammalia>
Subcellular location Nucleus. Note=Colocalizes with PCNA within the replication foci in S-phase cells.
else
Subcellular location Nucleus.
end case
case <FTTag:PIP>
Domain The PIP-box (PCNA interacting peptide) motif mediates the interaction with PCNA and localization to replication foci.
end case
Similarity Belongs to the helicase family. RAD3/XPD subfamily.

Keywords [?]

ATP-binding
DNA damage
DNA repair
DNA-binding
Helicase
Hydrolase
Nucleotide-binding
Nucleus
case <FTGroup:1>
4Fe-4S
Iron
Iron-sulfur
Metal-binding
end case

Gene Ontology [?]

GO:0005634; Cellular component: nucleus.
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0005524; Molecular function: ATP binding.
GO:0003678; Molecular function: DNA helicase activity.
GO:0003677; Molecular function: DNA binding.
GO:0046872; Molecular function: metal ion binding.
GO:0006281; Biological process: DNA repair.
GO:0010569; Biological process: regulation of double-strand break repair via homologous recombination.
case <OC:Vertebrata>
GO:0000723; Biological process: telomere maintenance.
end case

Cross-references [?]

PROSITE PS51193; HELICASE_ATP_BIND_2; 1; trigger=PRU00541;
PS00690; DEAH_ATP_HELICASE; 1;
Pfam PF06733; DEAD_2; 1;
PF13307; Helicase_C_2; 1;
NCBIfam TIGR00604; rad3; 1;

Features [?]

case <OC:Vertebrata>
From: RTEL1_HUMAN (Q9NZ71)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     151     167       Nuclear localization signal     [RK]-[RK]-x(11)-R-[RK]-K-x  
MOTIF     871     877       Nuclear localization signal     x(4)-[RK]-[RK]-K  
end case
case <OC:Mammalia>
MOTIF     1178     1185       PIP-box   PIP   Q-x(2)-[ILVAMG]-x(2)-[FL]-[FL]  
end case
BINDING     145     145       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     163     163       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     172     172       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     207     207       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1

Additional information [?]

Size range 783-1334 amino acids
Related rules None
Fusion None


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