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Annotation rule MF_03127 |
Accession | MF_03127 |
Dates | 13-AUG-2010 (Created) 20-NOV-2019 (Last updated, Version 7) |
Name | Adenylosucc_synth_vert_acid |
Scope | Eukaryota; Vertebrata |
Templates | P30520 (PURA2_HUMAN); P0A7D4 (PURA_ECOLI): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. |
Catalytic activity | RHEA:15753: GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate
EC 6.3.4.4 |
Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. |
Pathway | Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the adenylosuccinate synthetase family. |
PROSITE | PS01266; ADENYLOSUCCIN_SYN_1; 1; |
PS00513; ADENYLOSUCCIN_SYN_2; 1; | |
Pfam | PF00709; Adenylsucc_synt; 1; |
TIGRFAMs | TIGR00184; PurA; 1; |
From: PURA2_HUMAN (P30520) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
INIT_MET (Optional) | 1 | 1 | Removed | M | 1 | |||||||
CHAIN | 2 | Cter | Adenylosuccinate synthetase isozyme 2 | 1 | ||||||||
MOD_RES (Optional) | 2 | 2 | N-acetylalanine | A | 1 |