HAMAP rule MF_03127
General rule information
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Accession | MF_03127 |
Dates | 13-AUG-2010 (Created) 19-NOV-2022 (Last updated, Version 10) |
Name | Adenylosucc_synth_vert_acid |
Scope | Eukaryota; Vertebrata |
Templates | P30520 (PURA2_HUMAN); P0A7D4 (PURA_ECOLI): [Recover all] |
case <OC:Eukaryota>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. |
Catalytic activity | RHEA:15753: GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate
EC 6.3.4.4 |
Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. |
Pathway | Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the adenylosuccinate synthetase family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0004019; Molecular function: adenylosuccinate synthase activity.
GO:0005525; Molecular function: GTP binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006164; Biological process: purine nucleotide biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0005525; Molecular function: GTP binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006164; Biological process: purine nucleotide biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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PROSITE | PS01266; ADENYLOSUCCIN_SYN_1; 1; |
PS00513; ADENYLOSUCCIN_SYN_2; 1; | |
Pfam | PF00709; Adenylsucc_synt; 1; |
TIGRFAMs | TIGR00184; PurA; 1; |
Features
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case <OC:Mammalia>
From: PURA2_HUMAN (P30520) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
INIT_MET (Optional) | 1 | 1 | Removed | M | 1 | |||||||
CHAIN | 2 | Cter | Adenylosuccinate synthetase isozyme 2 | 1 | ||||||||
MOD_RES (Optional) | 2 | 2 | N-acetylalanine | A | 1 |
end case
Additional information
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