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Annotation rule MF_03136
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General rule information [?]

Accession MF_03136
Dates 22-OCT-2010 (Created)
20-NOV-2019 (Last updated, Version 5)
Name qutE
Scope
Eukaryota; Fungi
Template P05147 (3DHQ_EMENI)
case <OC:Eukaryota>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
3DHQ
Protein name
RecName: Full=Catabolic 3-dehydroquinase;
Short=cDHQase;
EC 4.2.1.10;
AltName: Full=3-dehydroquinate dehydratase;
case <OC:Pezizomycotina> and not <OC:Neurospora>
Gene name
qutE
else case <OC:Neurospora>
Gene name
qa-2
else case <OC:Saccharomycotina>
Gene name
DQD1
end case

Comments [?]

Function Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.
Catalytic activity RHEA:21096: 3-dehydroquinate = 3-dehydroshikimate + H2O
EC 4.2.1.10
Pathway Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.
Subunit Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.
Similarity Belongs to the type-II 3-dehydroquinase family.

Keywords [?]

Lyase
Quinate metabolism

Gene Ontology [?]

GO:0003855; Molecular function: 3-dehydroquinate dehydratase activity.
GO:0019630; Biological process: quinate metabolic process.

Cross-references [?]

Pfam PF01220; DHquinase_II; 1;
TIGRFAMs TIGR01088; AroQ; 1;
PIRSF PIRSF001399; DHquinase_II; 1;
PROSITE PS01029; DEHYDROQUINASE_II; 1;

Features [?]

From: 3DHQ_EMENI (P05147)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     102     103       Substrate binding     [IV]-[ST]  
ACT_SITE     24     24       Proton acceptor     Y  
ACT_SITE     101     101       Proton donor     H  
BINDING     75     75       Substrate     N  
BINDING     81     81       Substrate     H  
BINDING     88     88       Substrate     D  
BINDING     112     112       Substrate     R  
SITE     19     19       Transition state stabilizer     R  

Additional information [?]

Size range 144-175 amino acids
Related rules None
Fusion None


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