HAMAP rule MF_03136
General rule information
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Accession | MF_03136 |
Dates | 22-OCT-2010 (Created) 1-JUN-2023 (Last updated, Version 8) |
Name | qutE |
Scope | Eukaryota; Fungi |
Template | P05147 (3DHQ_EMENI) |
case <OC:Eukaryota>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
case <OC:Pezizomycotina> and not <OC:Neurospora>
Gene name |
|
else case <OC:Neurospora>
Gene name |
|
else case <OC:Saccharomycotina>
Gene name |
|
end case
Comments
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Function | Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway. |
Catalytic activity | RHEA:21096: 3-dehydroquinate = 3-dehydroshikimate + H2O
EC 4.2.1.10 |
Pathway | Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2. |
Subunit | Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another. |
Similarity | Belongs to the type-II 3-dehydroquinase family. |
Keywords
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Gene Ontology
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GO:0003855; Molecular function: 3-dehydroquinate dehydratase activity.
GO:0019630; Biological process: quinate metabolic process.
GO:0019630; Biological process: quinate metabolic process.
Cross-references
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Pfam | PF01220; DHquinase_II; 1; |
NCBIfam | TIGR01088; AroQ; 1; |
PIRSF | PIRSF001399; DHquinase_II; 1; |
PROSITE | PS01029; DEHYDROQUINASE_II; 1; |
Features
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From: 3DHQ_EMENI (P05147) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 102 | 103 | /ligand="substrate | [IV]-[ST] | ||||||||
ACT_SITE | 24 | 24 | Proton acceptor | Y | ||||||||
ACT_SITE | 101 | 101 | Proton donor | H | ||||||||
BINDING | 75 | 75 | /ligand="substrate | N | ||||||||
BINDING | 81 | 81 | /ligand="substrate | H | ||||||||
BINDING | 88 | 88 | /ligand="substrate | D | ||||||||
BINDING | 112 | 112 | /ligand="substrate | R | ||||||||
SITE | 19 | 19 | Transition state stabilizer | R |
Additional information
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Size range | 144-175 amino acids |
Related rules | None |
Fusion | None |