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HAMAP rule MF_03136

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General rule information [?]

Accession MF_03136
Dates 22-OCT-2010 (Created)
7-DEC-2023 (Last updated, Version 9)
Name qutE
Scope(s) Eukaryota
Template(s) P05147 (3DHQ_EMENI); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_00169 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier 3DHQ
Protein name RecName: Full=Catabolic 3-dehydroquinase;
AltName: Full=3-dehydroquinate dehydratase;
case <OC:Pezizomycotina> and not <OC:Neurospora>
Gene name Name=qutE;
else case <OC:Neurospora>
Gene name Name=qa-2;
else case <OC:Saccharomycotina>
Gene name Name=DQD1;
end case

Comments [?]

FUNCTIONIs involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.
CATALYTIC ACTIVITY Reaction=3-dehydroquinate = 3-dehydroshikimate + H2O; Xref=Rhea:RHEA:21096, ChEBI:CHEBI:15377, ChEBI:CHEBI:16630, ChEBI:CHEBI:32364; EC=;
PATHWAYAromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.
SUBUNITHomododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.
SIMILARITYBelongs to the type-II 3-dehydroquinase family.

Keywords [?]

Gene Ontology [?]

GO:0003855; Molecular function:3-dehydroquinate dehydratase activity
GO:0019630; Biological process:quinate metabolic process

Cross-references [?]

Pfam PF01220; DHquinase_II; 1;
NCBIfam TIGR01088; AroQ; 1;
PIRSF PIRSF001399; DHquinase_II; 1;

Features [?]

From: 3DHQ_EMENI (P05147)
Key From To Description Tag Condition FTGroup
BINDING 102 103 /ligand="substrate" [IV]-[ST]
ACT_SITE 24 24 /note="Proton acceptor" Y
ACT_SITE 101 101 /note="Proton donor" H
BINDING 75 75 /ligand="substrate" N
BINDING 81 81 /ligand="substrate" H
BINDING 88 88 /ligand="substrate" D
BINDING 112 112 /ligand="substrate" R
SITE 19 19 /note="Transition state stabilizer" R

Additional information [?]

Size range 144-175 amino acids
Related rules None
Fusion Nter: None Cter: None

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