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Annotation rule MF_03145
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General rule information [?]

Accession MF_03145
Dates 7-APR-2011 (Created)
20-NOV-2019 (Last updated, Version 7)
Name Adenine_deaminase_euk
Scope
Eukaryota; Fungi
Templates Q9I6Y4 (ADE_PSEAE); P53909 (ADE_YEAST); Q8X1T6 (ADE_EMENI): [Recover all]
case <OC:Fungi>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ADE
Protein name
RecName: Full=Adenine deaminase;
Short=ADE;
EC 3.5.4.2;
AltName: Full=Adenine aminohydrolase;
Short=AAH;
Gene name
AAH1

Comments [?]

Function Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
Catalytic activity RHEA:23688: adenine + H(+) + H2O = hypoxanthine + NH4(+)
EC 3.5.4.2
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
Subcellular location Cytoplasm. Nucleus.
Similarity Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0005634; Cellular component: nucleus.
GO:0000034; Molecular function: adenine deaminase activity.
GO:0006146; Biological process: adenine catabolic process.
GO:0043103; Biological process: hypoxanthine salvage.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

Pfam PF00962; A_deaminase; 1;
TIGRFAMs TIGR01430; Aden_deam; 1;
PROSITE PS00485; A_DEAMINASE; 0-1;

Features [?]

From: ADE_PSEAE (Q9I6Y4)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     197     197       Proton donor     E  
METAL     14     14       Zinc; catalytic     H   1
METAL     16     16       Zinc; catalytic     H   1
METAL     194     194       Zinc; catalytic     H   1
METAL     275     275       Zinc; catalytic     D   1
BINDING     276     276       Substrate     D  
SITE     218     218       Important for catalytic activity     H  

Additional information [?]

Size range 315-367 amino acids
Related rules None
Fusion None