HAMAP rule MF_03148
General rule information
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Accession | MF_03148 |
Dates | 9-AUG-2011 (Created) 1-JUN-2023 (Last updated, Version 14) |
Name | HAM1_NTPase |
Scope | Eukaryota |
Templates | Q9BY32 (ITPA_HUMAN); Q9D892 (ITPA_MOUSE); P47119 (ITPA_YEAST): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
case <OC:Vertebrata>
Gene name |
|
else case <OC:Caenorhabditis>
Gene name |
|
else case <OC:Saccharomycotina>
Gene name |
|
end case
Comments
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case <OC:Vertebrata>
Function | Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. |
else case <OC:Saccharomyces>
Function | Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and 5-bromodeoxyuridine 5'-triphosphate (BrdUTP) to their respective monophosphate derivatives. Xanthosine 5'-triphosphate (XTP) is also a potential substrate. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. |
else
Function | Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. |
end case
Catalytic activity | RHEA:23996: a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)
EC 3.6.1.9 PhysiologicalDirection=left-to-right (RHEA:23997) |
RHEA:44644: a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)
EC 3.6.1.9 PhysiologicalDirection=left-to-right (RHEA:44645) |
|
RHEA:29399: H2O + ITP = diphosphate + H(+) + IMP
EC 3.6.1.9 PhysiologicalDirection=left-to-right (RHEA:29400) |
|
RHEA:28342: dITP + H2O = dIMP + diphosphate + H(+)
EC 3.6.1.9 PhysiologicalDirection=left-to-right (RHEA:28343) |
|
RHEA:28610: H2O + XTP = diphosphate + H(+) + XMP
EC 3.6.1.9 PhysiologicalDirection=left-to-right (RHEA:28611) |
|
Cofactor | Mg(2+) Mn(2+) Note: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+). |
Subunit | Homodimer. |
case <OC:Fungi>
Subcellular location | Cytoplasm. Nucleus. |
else
Subcellular location | Cytoplasm. |
end case
Similarity | Belongs to the HAM1 NTPase family. |
Keywords
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case <FTGroup:1>
end case
case <OC:Fungi>
end case
Gene Ontology
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case <OC:Fungi>
GO:0005634; Cellular component: nucleus.
end case
GO:0005737; Cellular component: cytoplasm.
GO:0047429; Molecular function: nucleoside triphosphate diphosphatase activity.
GO:0009204; Biological process: deoxyribonucleoside triphosphate catabolic process.
GO:0047429; Molecular function: nucleoside triphosphate diphosphatase activity.
GO:0009204; Biological process: deoxyribonucleoside triphosphate catabolic process.
Cross-references
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Features
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case <OC:Mammalia>
From: ITPA_HUMAN (Q9BY32) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
INIT_MET | Nter | Nter | Removed | M | 1 | |||||||
MOD_RES | Nter+1 | Nter+1 | N-acetylalanine | A | 1 |
end case
Additional information
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Size range | 183-234 amino acids |
Related rules | None |
Fusion | None |