HAMAP rule MF_03149

General rule information [?]

Accession	MF_03149
Dates	18-AUG-2011 (Created) 1-JUN-2023 (Last updated, Version 8)
Name	GatC_euk
Scope(s)	Eukaryota
Template(s)	O43716 (GATC_HUMAN); F4JV80 (GATC_ARATH); [ Recover all ]
Triggered by	case c? <OC:Eukaryota> HAMAP; MF_00122 (Get profile general information and statistics) end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GATC
case <OC:Viridiplantae>
Protein name	RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit C, chloroplastic/mitochondrial; Short=Glu-AdT subunit C; EC=6.3.5.-;
else
Protein name	RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Short=Glu-AdT subunit C; EC=6.3.5.-;
end case
case <OC:Vertebrata> or <OC:Viridiplantae>
Gene name	Name=GATC;
end case

Comments [?]

case <OC:Viridiplantae>
FUNCTION	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
else
FUNCTION	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
end case
CATALYTIC ACTIVITY	Reaction=ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate; Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216;
case <OC:Vertebrata>
SUBUNIT	Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (@gn(QRSL1)), B (@gn(GATB)) and C (@gn(GATC)) subunits.
else
SUBUNIT	Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.
end case
case <OC:Viridiplantae>
SUBCELLULAR LOCATION	Mitochondrion. Plastid, chloroplast.
else
SUBCELLULAR LOCATION	Mitochondrion.
end case
case <OC:Viridiplantae> or not <AnyFeature:TransitM>
MISCELLANEOUS	This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
SIMILARITY	Belongs to the GatC family.

Keywords [?]

case <OC:Viridiplantae>
Chloroplast
Plastid
end case
Mitochondrion
ATP-binding
Ligase
Nucleotide-binding
Protein biosynthesis

Gene Ontology [?]

case <OCellular component:Viridiplantae>
GO:0009507; Cellular component:chloroplast
end case
GO:0005739; Cellular component:mitochondrion
GO:0030956; Cellular component:glutamyl-tRNA(Gln) amidotransferase complex
GO:0050567; Molecular function:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
GO:0016884; Molecular function:carbon-nitrogen ligase activity, with glutamine as amido-N-donor
GO:0070681; Biological process:glutaminyl-tRNAGln biosynthesis via transamidation
GO:0032543; Biological process:mitochondrial translation

Cross-references [?]

Pfam	PF02686; Glu-tRNAGln; 1;
NCBIfam	TIGR00135; GatC; 1;
General	TransitM; -; 0-1;

Features [?]

Additional information [?]

Size range	116-198 amino acids
Related rules	None
Fusion	Nter: None Cter: None

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