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| Annotation rule MF_03151 |
General rule information
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| Accession | MF_03151 |
| Dates | 18-AUG-2011 (Created) 20-NOV-2019 (Last updated, Version 6) |
| Name | GatF |
| Scope | Eukaryota; Saccharomycotina |
| Template | P53260 (GATF_YEAST) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion. |
| Catalytic activity | RHEA:17521: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate |
| Subunit | Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits. |
| Subcellular location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
case not <AnyFeature:TransitM>
| Miscellaneous | This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
end case
| Similarity | Belongs to the GatF family. |
Keywords
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ATP-binding
Ligase
Membrane
Mitochondrion
Mitochondrion inner membrane
Nucleotide-binding
Protein biosynthesis
Ligase
Membrane
Mitochondrion
Mitochondrion inner membrane
Nucleotide-binding
Protein biosynthesis
Gene Ontology
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GO:0005739; Cellular component: mitochondrion.
GO:0030956; Cellular component: glutamyl-tRNA(Gln) amidotransferase complex.
GO:0050567; Molecular function: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity.
GO:0016884; Molecular function: carbon-nitrogen ligase activity, with glutamine as amido-N-donor.
GO:0070681; Biological process: glutaminyl-tRNAGln biosynthesis via transamidation.
GO:0032543; Biological process: mitochondrial translation.
GO:0030956; Cellular component: glutamyl-tRNA(Gln) amidotransferase complex.
GO:0050567; Molecular function: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity.
GO:0016884; Molecular function: carbon-nitrogen ligase activity, with glutamine as amido-N-donor.
GO:0070681; Biological process: glutaminyl-tRNAGln biosynthesis via transamidation.
GO:0032543; Biological process: mitochondrial translation.
Computed features
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| General | TransitM; -; 0-1; trigger=yes; |
Additional information
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| Size range | 149-190 amino acids |
| Related rules | None |
| Fusion | None |