HAMAP rule MF_03151
General rule information
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Accession | MF_03151 |
Dates | 18-AUG-2011 (Created)
20-NOV-2019 (Last updated, Version 6) |
Name | GatF |
Scope(s) |
Eukaryota Saccharomycotina |
Template(s) | P53260 (GATF_YEAST); [ Recover all ] |
Triggered by |
HAMAP; MF_03151 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GATF |
Protein name | RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial; Short=Glu-AdT subunit F; EC=6.3.5.-; |
Gene name | Name=GTF1; |
Comments
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FUNCTION | Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion. |
CATALYTIC ACTIVITY | Reaction=ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate; Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216; |
SUBUNIT | Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits. |
SUBCELLULAR LOCATION | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
case not <AnyFeature:TransitM> | |
MISCELLANEOUS | This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
end case | |
SIMILARITY | Belongs to the GatF family. |
Keywords
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ATP-binding |
Ligase |
Membrane |
Mitochondrion |
Mitochondrion inner membrane |
Nucleotide-binding |
Protein biosynthesis |
Gene Ontology
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GO:0005739; Cellular component:mitochondrion |
GO:0030956; Cellular component:glutamyl-tRNA(Gln) amidotransferase complex |
GO:0050567; Molecular function:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity |
GO:0016884; Molecular function:carbon-nitrogen ligase activity, with glutamine as amido-N-donor |
GO:0070681; Biological process:glutaminyl-tRNAGln biosynthesis via transamidation |
GO:0032543; Biological process:mitochondrial translation |
Cross-references
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General | TransitM; -; 0-1; |
Features
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Additional information
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Size range | 149-190 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |