HAMAP rule MF_03151

Accession	MF_03151
Dates	18-AUG-2011 (Created) 20-NOV-2019 (Last updated, Version 6)

Name

GatF

Scope

Eukaryota; Saccharomycotina

Template

P53260 (GATF_YEAST)

Triggered by

HAMAP; MF_03151 (Get profile general information and statistics)

Identifier

GATF

Protein name

RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial; Short=Glu-AdT subunit F; EC 6.3.5.-;

Gene name

GTF1

Function	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion.
Catalytic activity	RHEA:17521: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate
Subunit	Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Miscellaneous

This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

Similarity

Belongs to the GatF family.

ATP-binding
Ligase
Membrane
Mitochondrion
Mitochondrion inner membrane
Nucleotide-binding
Protein biosynthesis

GO:0005739; Cellular component: mitochondrion.
GO:0030956; Cellular component: glutamyl-tRNA(Gln) amidotransferase complex.
GO:0050567; Molecular function: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity.
GO:0016884; Molecular function: carbon-nitrogen ligase activity, with glutamine as amido-N-donor.
GO:0070681; Biological process: glutaminyl-tRNAGln biosynthesis via transamidation.
GO:0032543; Biological process: mitochondrial translation.

General

TransitM; -; 0-1; trigger=yes;

Size range	149-190 amino acids
Related rules	None
Fusion	None

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