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HAMAP rule MF_03151

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General rule information [?]

Accession MF_03151
Dates 18-AUG-2011 (Created)
20-NOV-2019 (Last updated, Version 6)
Name GatF
Scope(s) Eukaryota
Template(s) P53260 (GATF_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03151 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GATF
Protein name RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial;
                 Short=Glu-AdT subunit F;
Gene name Name=GTF1;

Comments [?]

FUNCTIONAllows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion.
CATALYTIC ACTIVITY Reaction=ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate; Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216;
SUBUNITSubunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.
SUBCELLULAR LOCATIONMitochondrion inner membrane; Peripheral membrane protein; Matrix side.
case not <AnyFeature:TransitM>
MISCELLANEOUSThis protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
SIMILARITYBelongs to the GatF family.

Keywords [?]

Gene Ontology [?]

GO:0005739; Cellular component:mitochondrion
GO:0030956; Cellular component:glutamyl-tRNA(Gln) amidotransferase complex
GO:0050567; Molecular function:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
GO:0016884; Molecular function:carbon-nitrogen ligase activity, with glutamine as amido-N-donor
GO:0070681; Biological process:glutaminyl-tRNAGln biosynthesis via transamidation
GO:0032543; Biological process:mitochondrial translation

Cross-references [?]

General TransitM; -; 0-1;

Features [?]

Additional information [?]

Size range 149-190 amino acids
Related rules None
Fusion Nter: None Cter: None

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