HAMAP rule MF_03168
General rule information
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| Accession | MF_03168 |
| Dates | 19-FEB-2009 (Created)
1-JUN-2023 (Last updated, Version 16) |
| Name | Adenylate_kinase_AK2 |
| Scope(s) |
Eukaryota |
| Template(s) | P54819 (KAD2_HUMAN); Q9U915 (KAD2_DROME); P07170 (KAD2_YEAST); [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_03168 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KAD2 |
| case <OC:Vertebrata> | |
| Protein name | RecName: Full=Adenylate kinase 2, mitochondrial; Short=AK 2; EC=2.7.4.3; AltName: Full=ATP-AMP transphosphorylase 2; AltName: Full=ATP:AMP phosphotransferase; AltName: Full=Adenylate monophosphate kinase; |
| else | |
| Protein name | RecName: Full=Adenylate kinase; EC=2.7.4.3; AltName: Full=ATP-AMP transphosphorylase; AltName: Full=ATP:AMP phosphotransferase; AltName: Full=Adenylate kinase cytosolic and mitochondrial; AltName: Full=Adenylate monophosphate kinase; |
| end case | |
| case <OC:Saccharomyces> | |
| Protein name | + Flags: Precursor; |
| end case | |
| case <OC:Vertebrata> | |
| Gene name | Name=AK2; |
| end case | |
| case <OC:Caenorhabditis> | |
| Gene name | Name=let-754; |
| end case | |
| case <OC:Insecta> | |
| Gene name | Name=Ak2; |
| end case | |
| case <OC:Fungi> | |
| Gene name | Name=ADK1; |
| end case | |
Comments
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| case <OC:Vertebrata> | |
| FUNCTION | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. |
| else | |
| FUNCTION | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3; |
| SUBUNIT | Monomer. |
| case <OC:Vertebrata> | |
| SUBCELLULAR LOCATION | Mitochondrion intermembrane space. |
| else | |
| SUBCELLULAR LOCATION | Cytoplasm, cytosol. Mitochondrion intermembrane space. Note=Predominantly mitochondrial. |
| end case | |
| DOMAIN | Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. |
| SIMILARITY | Belongs to the adenylate kinase family. AK2 subfamily. |
Keywords
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| ATP-binding | |
| Kinase | |
| Mitochondrion | |
| Nucleotide-binding | |
| Transferase | |
| case not <OC:Vertebrata> | |
| Cytoplasm | |
| end case | |
| case <FTTag:acetyl> | |
| Acetylation | |
| end case | |
| case <FTTag:disulfid> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| GO:0005758; Cellular component:mitochondrial intermembrane space | |
| case not <OCellular component:Vertebrata> | |
| GO:0005737; Cellular component:cytoplasm | |
| end case | |
| GO:0004017; Molecular function:adenylate kinase activity | |
| GO:0006172; Biological process:ADP biosynthetic process | |
| GO:0046033; Biological process:AMP metabolic process | |
| GO:0046034; Biological process:ATP metabolic process | |
Cross-references
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| PROSITE | PS00113; ADENYLATE_KINASE; 1; |
| Pfam | PF00406; ADK; 1; |
| Pfam | PF05191; ADK_lid; 1; |
| PRINTS | PR00094; ADENYLTKNASE; 1; |
| NCBIfam | TIGR01351; adk; 1; |
Features
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| From: KAD2_YEAST (P07170) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 16 | 21 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-[AS]-G-K-G-T | ||||||||
| BINDING | 63 | 65 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
x-L-V | ||||||||
| BINDING | 92 | 95 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
G-F-P-R | ||||||||
| BINDING | 143 | 144 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[ST]-Y | ||||||||
| REGION | 36 | 65 | /note="NMPbind" | |||||||||
| REGION | 133 | 170 | /note="LID" | |||||||||
| BINDING | 37 | 37 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
T | ||||||||
| BINDING | 42 | 42 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
R | ||||||||
| BINDING | 99 | 99 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
Q | ||||||||
| BINDING | 134 | 134 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
R | ||||||||
| BINDING | 167 | 167 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
R | ||||||||
| BINDING | 178 | 178 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
R | ||||||||
| BINDING | 206 | 206 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
| case <OC:Saccharomyces> | ||||||||||||
| PROPEP | 1 | 2 | /note="Removed in mature form" | |||||||||
| CHAIN | 3 | Cter | /note="Adenylate kinase" | |||||||||
| MOD_RES | 3 | 3 | /note="N-acetylserine" | acetyl | S | |||||||
| end case | ||||||||||||
| From: KAD2_HUMAN (P54819) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Mammalia> | ||||||||||||
| INIT_MET | 1 | 1 | /note="Removed" | M | ||||||||
| end case | ||||||||||||
| case <OC:Vertebrata> | ||||||||||||
| DISULFID | 42 | 92 | disulfid | C-x*-C | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 220-278 amino acids |
| Related rules |
MF_00235 MF_03169 MF_03170 MF_03171 MF_03172 |
| Fusion | Nter: None Cter: None |