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HAMAP rule MF_03168

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General rule information [?]

Accession MF_03168
Dates 19-FEB-2009 (Created)
1-JUN-2023 (Last updated, Version 16)
Name Adenylate_kinase_AK2
Scope
Eukaryota
Templates P54819 (KAD2_HUMAN); Q9U915 (KAD2_DROME); P07170 (KAD2_YEAST): [Recover all]
case <OC:Eukaryota>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KAD2
case <OC:Vertebrata>
Protein name
RecName: Full=Adenylate kinase 2, mitochondrial;
Short=AK 2;
EC 2.7.4.3;
AltName: Full=ATP-AMP transphosphorylase 2;
AltName: Full=ATP:AMP phosphotransferase;
AltName: Full=Adenylate monophosphate kinase;
else
Protein name
RecName: Full=Adenylate kinase;
EC 2.7.4.3;
AltName: Full=ATP-AMP transphosphorylase;
AltName: Full=ATP:AMP phosphotransferase;
AltName: Full=Adenylate kinase cytosolic and mitochondrial;
AltName: Full=Adenylate monophosphate kinase;
end case
case <OC:Saccharomyces>
Protein name
Precursor;
end case
case <OC:Vertebrata>
Gene name
AK2
end case
case <OC:Caenorhabditis>
Gene name
let-754
end case
case <OC:Insecta>
Gene name
Ak2
end case
case <OC:Fungi>
Gene name
ADK1
end case

Comments [?]

case <OC:Vertebrata>
Function Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
else
Function Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
end case
Catalytic activity RHEA:12973: AMP + ATP = 2 ADP
EC 2.7.4.3
Subunit Monomer.
case <OC:Vertebrata>
Subcellular location Mitochondrion intermembrane space.
else
Subcellular location Cytoplasm, cytosol. Mitochondrion intermembrane space. Note=Predominantly mitochondrial.
end case
Domain Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
Similarity Belongs to the adenylate kinase family. AK2 subfamily.

Keywords [?]

ATP-binding
Kinase
Mitochondrion
Nucleotide-binding
Transferase
case not <OC:Vertebrata>
Cytoplasm
end case
case <FTTag:acetyl>
Acetylation
end case
case <FTTag:disulfid>
Disulfide bond
end case

Gene Ontology [?]

GO:0005758; Cellular component: mitochondrial intermembrane space.
case not <OC:Vertebrata>
GO:0005737; Cellular component: cytoplasm.
end case
GO:0004017; Molecular function: adenylate kinase activity.
GO:0006172; Biological process: ADP biosynthetic process.
GO:0046033; Biological process: AMP metabolic process.
GO:0046034; Biological process: ATP metabolic process.

Cross-references [?]

PROSITE PS00113; ADENYLATE_KINASE; 1;
Pfam PF00406; ADK; 1;
PF05191; ADK_lid; 1;
PRINTS PR00094; ADENYLTKNASE; 1;
NCBIfam TIGR01351; adk; 1;

Features [?]

From: KAD2_YEAST (P07170)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     16     21       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G-[AS]-G-K-G-T  
BINDING     63     65       /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215     x-L-V  
BINDING     92     95       /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215     G-F-P-R  
BINDING     143     144       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [ST]-Y  
REGION     36     65       NMPbind        
REGION     133     170       LID        
BINDING     37     37       /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215     T  
BINDING     42     42       /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215     R  
BINDING     99     99       /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215     Q  
BINDING     134     134       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     R  
BINDING     167     167       /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215     R  
BINDING     178     178       /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215     R  
BINDING     206     206       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616        
case <OC:Saccharomyces>
PROPEP     1     2       Removed in mature form        
CHAIN     3     Cter       Adenylate kinase        
MOD_RES     3     3       N-acetylserine   acetyl   S  
end case
case <OC:Mammalia>
From: KAD2_HUMAN (P54819)
INIT_MET     1     1       Removed     M  
end case
case <OC:Vertebrata>
DISULFID     42     92           disulfid   C-x*-C  
end case

Additional information [?]

Size range 220-278 amino acids
Related rules MF_00235 (KAD); MF_03169 (KAD3); MF_03170 (KAD4); MF_03171 (KAD1); MF_03172 (KCY)
Fusion None


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