HAMAP rule MF_03170
General rule information
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Accession | MF_03170 |
Dates | 11-MAR-2013 (Created)
1-JUN-2023 (Last updated, Version 14) |
Name | Adenylate_kinase_AK4 |
Scope(s) |
Eukaryota Vertebrata |
Template(s) | P27144 (KAD4_HUMAN); [ Recover all ] |
Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_03170 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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Identifier | KAD4 |
Protein name | RecName: Full=Adenylate kinase 4, mitochondrial; Short=AK 4; EC=2.7.4.10; EC=2.7.4.6; AltName: Full=Adenylate kinase 3-like; AltName: Full=GTP:AMP phosphotransferase AK4; |
Gene name | Name=AK4; Synonyms=AK3L1; |
Comments
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FUNCTION | Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. |
CATALYTIC ACTIVITY | Reaction=a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'- diphosphate + ADP; Xref=Rhea:RHEA:13749, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.10; |
CATALYTIC ACTIVITY | Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; |
CATALYTIC ACTIVITY | Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; |
SUBUNIT | Monomer. |
SUBCELLULAR LOCATION | Mitochondrion matrix. |
DOMAIN | Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis. |
SIMILARITY | Belongs to the adenylate kinase family. AK3 subfamily. |
Keywords
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Gene Ontology
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GO:0005759; Cellular component:mitochondrial matrix |
GO:0046899; Molecular function:nucleoside triphosphate adenylate kinase activity |
GO:0006172; Biological process:ADP biosynthetic process |
GO:0046033; Biological process:AMP metabolic process |
GO:0046039; Biological process:GTP metabolic process |
GO:0046034; Biological process:ATP metabolic process |
Cross-references
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PROSITE | PS00113; ADENYLATE_KINASE; 1; |
Pfam | PF00406; ADK; 1; |
Pfam | PF05191; ADK_lid; 1; |
PRINTS | PR00094; ADENYLTKNASE; 1; |
NCBIfam | TIGR01351; adk; 1; |
Features
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From: KAD4_HUMAN (P27144) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 15 | 20 | /ligand="a ribonucleoside 5'-triphosphate" /ligand_id="ChEBI:CHEBI:61557" |
G-x-G-K-G-T | ||||||||
BINDING | 62 | 64 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
x-L-V | ||||||||
BINDING | 89 | 92 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
G-F-P-R | ||||||||
BINDING | 135 | 136 | /ligand="a ribonucleoside 5'-triphosphate" /ligand_id="ChEBI:CHEBI:61557" |
V-Y | ||||||||
REGION | 35 | 64 | /note="NMPbind" | |||||||||
REGION | 125 | 162 | /note="LID" | |||||||||
BINDING | 36 | 36 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
S | ||||||||
BINDING | 41 | 41 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
R | ||||||||
BINDING | 96 | 96 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
Q | ||||||||
BINDING | 126 | 126 | /ligand="a ribonucleoside 5'-triphosphate" /ligand_id="ChEBI:CHEBI:61557" |
R | ||||||||
BINDING | 170 | 170 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
R | ||||||||
BINDING | 199 | 199 | /ligand="a ribonucleoside 5'-triphosphate" /ligand_id="ChEBI:CHEBI:61557" |
T |
Additional information
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Size range | 223-231 amino acids |
Related rules |
MF_00235 MF_03168 MF_03169 MF_03171 MF_03172 |
Fusion | Nter: None Cter: None |