HAMAP rule MF_03195

General rule information [?]

Accession	MF_03195
Dates	17-JUL-2015 (Created) 1-JUN-2023 (Last updated, Version 11)

Name	GMP_reduct_type1_euk

Scope

Eukaryota

Templates

Q9P2T1 (GMPR2_HUMAN); P36959 (GMPR1_HUMAN); Q4QEB3 (GMPR_LEIMA): [Recover all]

case <OC:Eukaryota>

Triggered by

HAMAP; MF_00596 (Get profile general information and statistics)

end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

GMPR

Protein name

RecName:		Full=GMP reductase;
		Short=GMPR;
		EC 1.7.1.7;
AltName:		Full=Guanosine 5'-monophosphate oxidoreductase;
		Short=Guanosine monophosphate reductase;

case <OC:Vertebrata> or <OC:Kinetoplastea>

Gene name

GMPR

end case

Comments [?]

Function	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Catalytic activity	RHEA:17185: IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH EC 1.7.1.7
Subunit	Homotetramer.

case <OC:Kinetoplastea> and <FTTag:Microbody>

Subcellular location

Glycosome.

end case

Similarity

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Keywords [?]

Metal-binding
NADP
Oxidoreductase
Potassium
Purine metabolism

case <OC:Kinetoplastea> and <FTTag:Microbody>

Glycosome
Peroxisome

end case

Gene Ontology [?]

GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.

Cross-references [?]

PROSITE	PS00487; IMP_DH_GMP_RED; 1;
	PS51371; CBS; 0-2; trigger=PRU00703;
Pfam	PF00478; IMPDH; 1;
	PF00571; CBS; 0-2;
NCBIfam	TIGR01305; GMP_reduct_1; 1;
PIRSF	PIRSF000235; GMP_reductase; 1;

Features [?]

From: GMPR2_HUMAN (Q9P2T1)

Key From To Description Tag Condition FTGroup

BINDING 26 27 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits S-R

BINDING 129 131 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain D-[IV]-A

BINDING 180 181 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain [IV]-G

BINDING 285 286 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain Y-R

BINDING 314 317 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits S-[ATG]-[CI]-[TS]

BINDING 219 221 /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115 D-G-G

BINDING 242 243 /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115 G-[GN]

BINDING 268 270 /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115 G-M-[AS]

BINDING 286 290 /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115 [RL]-[AV]-[SAP]-E-G

ACT_SITE 186 186 Thioimidate intermediate C

ACT_SITE 188 188 Proton donor/acceptor T

BINDING 181 181 /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 G

BINDING 183 183 /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 G

BINDING 186 186 /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 C

BINDING 189 189 /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 R

BINDING 78 78 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain [KR]

BINDING 269 269 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain M

case <OC:Kinetoplastea>

From: GMPR_LEIMA (Q4QEB3)

MOTIF 490 Cter Microbody targeting signal Microbody [AS]-K-[ML]

end case

Additional information [?]

Size range	339-553 amino acids
Related rules	None
Fusion	None

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