HAMAP rule MF_03195
General rule information
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Accession | MF_03195 |
Dates | 17-JUL-2015 (Created) 1-JUN-2023 (Last updated, Version 11) |
Name | GMP_reduct_type1_euk |
Scope | Eukaryota |
Templates | Q9P2T1 (GMPR2_HUMAN); P36959 (GMPR1_HUMAN); Q4QEB3 (GMPR_LEIMA): [Recover all] |
case <OC:Eukaryota>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
case <OC:Vertebrata> or <OC:Kinetoplastea>
Gene name |
|
end case
Comments
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Function | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. |
Catalytic activity | RHEA:17185: IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH
EC 1.7.1.7 |
Subunit | Homotetramer. |
case <OC:Kinetoplastea> and <FTTag:Microbody>
Subcellular location | Glycosome. |
end case
Similarity | Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. |
Keywords
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case <OC:Kinetoplastea> and <FTTag:Microbody>
end case
Gene Ontology
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GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.
GO:0006163; Biological process: purine nucleotide metabolic process.
Cross-references
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PROSITE | PS00487; IMP_DH_GMP_RED; 1; |
PS51371; CBS; 0-2; trigger=PRU00703; | |
Pfam | PF00478; IMPDH; 1; |
PF00571; CBS; 0-2; | |
NCBIfam | TIGR01305; GMP_reduct_1; 1; |
PIRSF | PIRSF000235; GMP_reductase; 1; |
Features
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From: GMPR2_HUMAN (Q9P2T1) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 26 | 27 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits | S-R | ||||||||
BINDING | 129 | 131 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | D-[IV]-A | ||||||||
BINDING | 180 | 181 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | [IV]-G | ||||||||
BINDING | 285 | 286 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | Y-R | ||||||||
BINDING | 314 | 317 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits | S-[ATG]-[CI]-[TS] | ||||||||
BINDING | 219 | 221 | /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115 | D-G-G | ||||||||
BINDING | 242 | 243 | /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115 | G-[GN] | ||||||||
BINDING | 268 | 270 | /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115 | G-M-[AS] | ||||||||
BINDING | 286 | 290 | /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115 | [RL]-[AV]-[SAP]-E-G | ||||||||
ACT_SITE | 186 | 186 | Thioimidate intermediate | C | ||||||||
ACT_SITE | 188 | 188 | Proton donor/acceptor | T | ||||||||
BINDING | 181 | 181 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 | G | ||||||||
BINDING | 183 | 183 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 | G | ||||||||
BINDING | 186 | 186 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 | C | ||||||||
BINDING | 189 | 189 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 | R | ||||||||
BINDING | 78 | 78 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | [KR] | ||||||||
BINDING | 269 | 269 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | M |
case <OC:Kinetoplastea>
From: GMPR_LEIMA (Q4QEB3) | ||||||||||||
MOTIF | 490 | Cter | Microbody targeting signal | Microbody | [AS]-K-[ML] |
end case
Additional information
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Size range | 339-553 amino acids |
Related rules | None |
Fusion | None |