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Annotation rule MF_03195 |
General rule information
[?]
Accession |
MF_03195 |
Dates |
17-JUL-2015 (Created) 11-FEB-2020 (Last updated, Version 6) |
Name |
GMP_reduct_type1_euk |
case <OC:Eukaryota>
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=GMP reductase;
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Short=GMPR;
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EC 1.7.1.7;
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AltName:
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Full=Guanosine 5'-monophosphate oxidoreductase;
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Short=Guanosine monophosphate reductase;
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case <OC:Vertebrata> or <OC:Kinetoplastea>
end case
Function |
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. |
Catalytic activity |
RHEA:17185: IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH
EC 1.7.1.7
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Subunit |
Homotetramer. |
case <OC:Kinetoplastea> and <FTTag:Microbody>
Subcellular location |
Glycosome. |
end case
Similarity |
Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. |
case <OC:Kinetoplastea> and <FTTag:Microbody>
end case
GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.
From: GMPR2_HUMAN (Q9P2T1) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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NP_BIND
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26
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27
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NADP; shared with neighboring subunit
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S-R
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NP_BIND
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129
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131
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NADP
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D-[IV]-A
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NP_BIND
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180
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181
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NADP
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[IV]-G
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NP_BIND
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285
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286
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NADP
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Y-R
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NP_BIND
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314
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317
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NADP; shared with neighboring subunit
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S-[ATG]-[CI]-[TS]
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REGION
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219
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221
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GMP binding
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D-G-G
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REGION
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242
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243
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GMP binding
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G-[GN]
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REGION
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268
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270
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GMP binding
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G-M-[AS]
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REGION
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286
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290
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GMP binding
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[RL]-[AV]-[SAP]-E-G
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ACT_SITE
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186
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186
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Thioimidate intermediate
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C
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ACT_SITE
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188
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188
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Proton donor/acceptor
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T
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METAL
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181
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181
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Potassium; via carbonyl oxygen
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G
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METAL
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183
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183
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Potassium; via carbonyl oxygen
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G
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METAL
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186
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186
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Potassium; via carbonyl oxygen
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C
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METAL
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189
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189
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Potassium
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R
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BINDING
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78
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78
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NADP
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[KR]
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BINDING
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269
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269
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NADP; via carbonyl oxygen
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M
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case <OC:Kinetoplastea>
From: GMPR_LEIMA (Q4QEB3) |
MOTIF
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490
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Cter
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Microbody targeting signal
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Microbody
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[AS]-K-[ML]
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end case
Additional information
[?]
Size range |
339-553 amino acids |
Related rules |
None |
Fusion |
None |