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HAMAP rule MF_03195

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General rule information [?]

Accession MF_03195
Dates 17-JUL-2015 (Created)
1-JUN-2023 (Last updated, Version 11)
Name GMP_reduct_type1_euk
Scope(s) Eukaryota
Template(s) Q9P2T1 (GMPR2_HUMAN); P36959 (GMPR1_HUMAN); Q4QEB3 (GMPR_LEIMA); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_00596 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GMPR
Protein name RecName: Full=GMP reductase;
                 Short=GMPR;
                 EC=1.7.1.7;
AltName: Full=Guanosine 5'-monophosphate oxidoreductase;
                 Short=Guanosine monophosphate reductase;
case <OC:Vertebrata> or <OC:Kinetoplastea>
Gene name Name=GMPR;
end case

Comments [?]

FUNCTIONCatalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
CATALYTIC ACTIVITY Reaction=IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH; Xref=Rhea:RHEA:17185, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57783, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115, ChEBI:CHEBI:58349; EC=1.7.1.7;
SUBUNITHomotetramer.
case <OC:Kinetoplastea> and <FTTag:Microbody>
SUBCELLULAR LOCATIONGlycosome.
end case
SIMILARITYBelongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Keywords [?]

Metal-binding
NADP
Oxidoreductase
Potassium
Purine metabolism
case <OC:Kinetoplastea> and <FTTag:Microbody>
Glycosome
Peroxisome
end case

Gene Ontology [?]

GO:0003920; Molecular function:GMP reductase activity
GO:0006163; Biological process:purine nucleotide metabolic process

Cross-references [?]

PROSITE PS00487; IMP_DH_GMP_RED; 1;
PROSITE PS51371; CBS; 0-2;
Pfam PF00478; IMPDH; 1;
Pfam PF00571; CBS; 0-2;
NCBIfam TIGR01305; GMP_reduct_1; 1;
PIRSF PIRSF000235; GMP_reductase; 1;

Features [?]

From: GMPR2_HUMAN (Q9P2T1)
Key From To Description Tag Condition FTGroup
BINDING 26 27 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"
/ligand_note="ligand shared between two neighboring subunits"
S-R
BINDING 129 131 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"
/ligand_note="ligand shared between two neighboring subunits"
/note="in other chain"
D-[IV]-A
BINDING 180 181 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"
/ligand_note="ligand shared between two neighboring subunits"
/note="in other chain"
[IV]-G
BINDING 285 286 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"
/ligand_note="ligand shared between two neighboring subunits"
/note="in other chain"
Y-R
BINDING 314 317 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"
/ligand_note="ligand shared between two neighboring subunits"
S-[ATG]-[CI]-[TS]
BINDING 219 221 /ligand="GMP"
/ligand_id="ChEBI:CHEBI:58115"
D-G-G
BINDING 242 243 /ligand="GMP"
/ligand_id="ChEBI:CHEBI:58115"
G-[GN]
BINDING 268 270 /ligand="GMP"
/ligand_id="ChEBI:CHEBI:58115"
G-M-[AS]
BINDING 286 290 /ligand="GMP"
/ligand_id="ChEBI:CHEBI:58115"
[RL]-[AV]-[SAP]-E-G
ACT_SITE 186 186 /note="Thioimidate intermediate" C
ACT_SITE 188 188 /note="Proton donor/acceptor" T
BINDING 181 181 /ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"
G
BINDING 183 183 /ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"
G
BINDING 186 186 /ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"
C
BINDING 189 189 /ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"
R
BINDING 78 78 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"
/ligand_note="ligand shared between two neighboring subunits"
/note="in other chain"
[KR]
BINDING 269 269 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"
/ligand_note="ligand shared between two neighboring subunits"
/note="in other chain"
M
From: GMPR_LEIMA (Q4QEB3)
Key From To Description Tag Condition FTGroup
case <OC:Kinetoplastea>
MOTIF 490 Cter /note="Microbody targeting signal" Microbody [AS]-K-[ML]
end case

Additional information [?]

Size range 339-553 amino acids
Related rules None
Fusion Nter: None Cter: None



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