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Annotation rule MF_03195
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General rule information [?]

Accession MF_03195
Dates 17-JUL-2015 (Created)
11-FEB-2020 (Last updated, Version 6)
Name GMP_reduct_type1_euk
Scope
Eukaryota
Templates Q9P2T1 (GMPR2_HUMAN); P36959 (GMPR1_HUMAN); Q4QEB3 (GMPR_LEIMA): [Recover all]
case <OC:Eukaryota>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GMPR
Protein name
RecName: Full=GMP reductase;
Short=GMPR;
EC 1.7.1.7;
AltName: Full=Guanosine 5'-monophosphate oxidoreductase;
Short=Guanosine monophosphate reductase;
case <OC:Vertebrata> or <OC:Kinetoplastea>
Gene name
GMPR
end case

Comments [?]

Function Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Catalytic activity RHEA:17185: IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH
EC 1.7.1.7
Subunit Homotetramer.
case <OC:Kinetoplastea> and <FTTag:Microbody>
Subcellular location Glycosome.
end case
Similarity Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Keywords [?]

Metal-binding
NADP
Oxidoreductase
Potassium
Purine metabolism
case <OC:Kinetoplastea> and <FTTag:Microbody>
Glycosome
Peroxisome
end case

Gene Ontology [?]

GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.

Cross-references [?]

PROSITE PS00487; IMP_DH_GMP_RED; 1;
PS51371; CBS; 0-2; trigger=PRU00703;
Pfam PF00478; IMPDH; 1;
PF00571; CBS; 0-2;
TIGRFAMs TIGR01305; GMP_reduct_1; 1;
PIRSF PIRSF000235; GMP_reductase; 1;

Features [?]

From: GMPR2_HUMAN (Q9P2T1)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     26     27       NADP; shared with neighboring subunit     S-R  
NP_BIND     129     131       NADP     D-[IV]-A  
NP_BIND     180     181       NADP     [IV]-G  
NP_BIND     285     286       NADP     Y-R  
NP_BIND     314     317       NADP; shared with neighboring subunit     S-[ATG]-[CI]-[TS]  
REGION     219     221       GMP binding     D-G-G  
REGION     242     243       GMP binding     G-[GN]  
REGION     268     270       GMP binding     G-M-[AS]  
REGION     286     290       GMP binding     [RL]-[AV]-[SAP]-E-G  
ACT_SITE     186     186       Thioimidate intermediate     C  
ACT_SITE     188     188       Proton donor/acceptor     T  
METAL     181     181       Potassium; via carbonyl oxygen     G  
METAL     183     183       Potassium; via carbonyl oxygen     G  
METAL     186     186       Potassium; via carbonyl oxygen     C  
METAL     189     189       Potassium     R  
BINDING     78     78       NADP     [KR]  
BINDING     269     269       NADP; via carbonyl oxygen     M  
case <OC:Kinetoplastea>
From: GMPR_LEIMA (Q4QEB3)
MOTIF     490     Cter       Microbody targeting signal   Microbody   [AS]-K-[ML]  
end case

Additional information [?]

Size range 339-553 amino acids
Related rules None
Fusion None


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