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HAMAP rule MF_03195

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General rule information [?]

Accession MF_03195
Dates 17-JUL-2015 (Created)
1-JUN-2023 (Last updated, Version 11)
Name GMP_reduct_type1_euk
Scope
Eukaryota
Templates Q9P2T1 (GMPR2_HUMAN); P36959 (GMPR1_HUMAN); Q4QEB3 (GMPR_LEIMA): [Recover all]
case <OC:Eukaryota>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GMPR
Protein name
RecName: Full=GMP reductase;
Short=GMPR;
EC 1.7.1.7;
AltName: Full=Guanosine 5'-monophosphate oxidoreductase;
Short=Guanosine monophosphate reductase;
case <OC:Vertebrata> or <OC:Kinetoplastea>
Gene name
GMPR
end case

Comments [?]

Function Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Catalytic activity RHEA:17185: IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH
EC 1.7.1.7
Subunit Homotetramer.
case <OC:Kinetoplastea> and <FTTag:Microbody>
Subcellular location Glycosome.
end case
Similarity Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Keywords [?]

case <OC:Kinetoplastea> and <FTTag:Microbody>
end case

Gene Ontology [?]

GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.

Cross-references [?]

PROSITE PS00487; IMP_DH_GMP_RED; 1;
PS51371; CBS; 0-2; trigger=PRU00703;
Pfam PF00478; IMPDH; 1;
PF00571; CBS; 0-2;
NCBIfam TIGR01305; GMP_reduct_1; 1;
PIRSF PIRSF000235; GMP_reductase; 1;

Features [?]

From: GMPR2_HUMAN (Q9P2T1)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     26     27       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits     S-R  
BINDING     129     131       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain     D-[IV]-A  
BINDING     180     181       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain     [IV]-G  
BINDING     285     286       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain     Y-R  
BINDING     314     317       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits     S-[ATG]-[CI]-[TS]  
BINDING     219     221       /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115     D-G-G  
BINDING     242     243       /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115     G-[GN]  
BINDING     268     270       /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115     G-M-[AS]  
BINDING     286     290       /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115     [RL]-[AV]-[SAP]-E-G  
ACT_SITE     186     186       Thioimidate intermediate     C  
ACT_SITE     188     188       Proton donor/acceptor     T  
BINDING     181     181       /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103     G  
BINDING     183     183       /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103     G  
BINDING     186     186       /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103     C  
BINDING     189     189       /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103     R  
BINDING     78     78       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain     [KR]  
BINDING     269     269       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain     M  
case <OC:Kinetoplastea>
From: GMPR_LEIMA (Q4QEB3)
MOTIF     490     Cter       Microbody targeting signal   Microbody   [AS]-K-[ML]  
end case

Additional information [?]

Size range 339-553 amino acids
Related rules None
Fusion None