HAMAP rule MF_03196
General rule information
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| Accession | MF_03196 |
| Dates | 1-SEP-2015 (Created)
1-JUN-2023 (Last updated, Version 11) |
| Name | UbiD_FDC_euk |
| Scope(s) |
Eukaryota Fungi Oomycota |
| Template(s) | Q03034 (FDC1_YEAST); Q9I6N5 (P2CDC_PSEAE); [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_01983 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FDC1 |
| Protein name | RecName: Full=Ferulic acid decarboxylase 1; EC=4.1.1.102; AltName: Full=Phenacrylate decarboxylase; |
| Gene name | Name=FDC1; |
Comments
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| FUNCTION | Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4- vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites. |
| CATALYTIC ACTIVITY | Reaction=(E)-4-coumarate + H(+) = 4-hydroxystyrene + CO2; Xref=Rhea:RHEA:33227, ChEBI:CHEBI:1883, ChEBI:CHEBI:12876, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526; EC=4.1.1.102; |
| CATALYTIC ACTIVITY | Reaction=(E)-cinnamate + H(+) = CO2 + styrene; Xref=Rhea:RHEA:46920, ChEBI:CHEBI:15378, ChEBI:CHEBI:15669, ChEBI:CHEBI:16526, ChEBI:CHEBI:27452; EC=4.1.1.102; |
| CATALYTIC ACTIVITY | Reaction=(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2; Xref=Rhea:RHEA:33807, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:29749, ChEBI:CHEBI:42438; EC=4.1.1.102; |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| COFACTOR | Name=prenyl-FMN; Xref=ChEBI:CHEBI:87746; Note=Binds 1 prenylated FMN (prenyl-FMN) per subunit.; |
| SUBUNIT | Homodimer. May form higher order oligomers. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the UbiD family. UbiD-like/FDC subfamily. |
Keywords
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Gene Ontology
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| GO:0005737; Cellular component:cytoplasm |
| GO:0016831; Molecular function:carboxy-lyase activity |
| GO:0046281; Biological process:cinnamic acid catabolic process |
| GO:0033494; Biological process:ferulate metabolic process |
Cross-references
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Features
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| From: FDC1_YEAST (Q03034) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 170 | 175 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746" |
[SN]-W-[SA]-[IV]-x-R | ||||||||
| BINDING | 192 | 193 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746" |
Q-[HD] | ||||||||
| ACT_SITE | 285 | 285 | /note="Proton donor" | E | ||||||||
| BINDING | 170 | 170 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
N | ||||||||
| BINDING | 193 | 193 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
H | ||||||||
| BINDING | 236 | 236 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
E | ||||||||
| BINDING | 236 | 236 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746" |
E | ||||||||
| BINDING | 394 | 394 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746" |
K | ||||||||
Additional information
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| Size range | 494-549 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |