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HAMAP rule MF_03196

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General rule information [?]

Accession MF_03196
Dates 1-SEP-2015 (Created)
1-JUN-2023 (Last updated, Version 11)
Name UbiD_FDC_euk
Scope(s) Eukaryota
Template(s) Q03034 (FDC1_YEAST); Q9I6N5 (P2CDC_PSEAE); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_01983 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FDC1
Protein name RecName: Full=Ferulic acid decarboxylase 1;
AltName: Full=Phenacrylate decarboxylase;
Gene name Name=FDC1;

Comments [?]

FUNCTIONCatalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4- vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.
CATALYTIC ACTIVITY Reaction=(E)-4-coumarate + H(+) = 4-hydroxystyrene + CO2; Xref=Rhea:RHEA:33227, ChEBI:CHEBI:1883, ChEBI:CHEBI:12876, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526; EC=;
CATALYTIC ACTIVITY Reaction=(E)-cinnamate + H(+) = CO2 + styrene; Xref=Rhea:RHEA:46920, ChEBI:CHEBI:15378, ChEBI:CHEBI:15669, ChEBI:CHEBI:16526, ChEBI:CHEBI:27452; EC=;
CATALYTIC ACTIVITY Reaction=(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2; Xref=Rhea:RHEA:33807, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:29749, ChEBI:CHEBI:42438; EC=;
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
COFACTOR Name=prenyl-FMN; Xref=ChEBI:CHEBI:87746; Note=Binds 1 prenylated FMN (prenyl-FMN) per subunit.;
SUBUNITHomodimer. May form higher order oligomers.
SIMILARITYBelongs to the UbiD family. UbiD-like/FDC subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
GO:0016831; Molecular function:carboxy-lyase activity
GO:0046281; Biological process:cinnamic acid catabolic process
GO:0033494; Biological process:ferulate metabolic process

Cross-references [?]

Pfam PF01977; UbiD; 1;
NCBIfam TIGR00148; TIGR00148; 1;

Features [?]

From: FDC1_YEAST (Q03034)
Key From To Description Tag Condition FTGroup
BINDING 170 175 /ligand="prenyl-FMN"
BINDING 192 193 /ligand="prenyl-FMN"
ACT_SITE 285 285 /note="Proton donor" E
BINDING 170 170 /ligand="Mn(2+)"
BINDING 193 193 /ligand="Mn(2+)"
BINDING 236 236 /ligand="Mn(2+)"
BINDING 236 236 /ligand="prenyl-FMN"
BINDING 394 394 /ligand="prenyl-FMN"

Additional information [?]

Size range 494-549 amino acids
Related rules None
Fusion Nter: None Cter: None

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