HAMAP logo

HAMAP rule MF_03196

Send feedback

General rule information [?]

Accession MF_03196
Dates 1-SEP-2015 (Created)
19-NOV-2022 (Last updated, Version 10)
Name UbiD_FDC_euk
Eukaryota; Fungi
Eukaryota; Oomycota
Templates Q03034 (FDC1_YEAST); Q9I6N5 (P2CDC_PSEAE): [Recover all]
case <OC:Eukaryota>
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Ferulic acid decarboxylase 1;
AltName: Full=Phenacrylate decarboxylase;
Gene name

Comments [?]

Function Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.
Catalytic activity RHEA:33227: (E)-4-coumarate + H(+) = 4-hydroxystyrene + CO2
RHEA:46920: (E)-cinnamate + H(+) = CO2 + styrene
RHEA:33807: (E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2
Cofactor Mn(2+)
Note: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
Subunit Homodimer. May form higher order oligomers.
Subcellular location Cytoplasm.
Similarity Belongs to the UbiD family. UbiD-like/FDC subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0016831; Molecular function: carboxy-lyase activity.
GO:0046281; Biological process: cinnamic acid catabolic process.
GO:0033494; Biological process: ferulate metabolic process.

Cross-references [?]

Pfam PF01977; UbiD; 1;
TIGRFAMs TIGR00148; TIGR00148; 1;

Features [?]

From: FDC1_YEAST (Q03034)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     170     175       /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746     [SN]-W-[SA]-[IV]-x-R  
BINDING     192     193       /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746     Q-[HD]  
ACT_SITE     285     285       Proton donor     E  
BINDING     170     170       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035     N  
BINDING     193     193       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035     H  
BINDING     236     236       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035     E  
BINDING     236     236       /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746     E  
BINDING     394     394       /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746     K  

Additional information [?]

Size range 494-549 amino acids
Related rules None
Fusion None