HAMAP rule MF_03196

General rule information [?]

Accession	MF_03196
Dates	1-SEP-2015 (Created) 19-NOV-2022 (Last updated, Version 10)

Name	UbiD_FDC_euk

Scope

Eukaryota; Fungi

Eukaryota; Oomycota

Templates

Q03034 (FDC1_YEAST); Q9I6N5 (P2CDC_PSEAE): [Recover all]

case <OC:Eukaryota>

Triggered by

HAMAP; MF_01983 (Get profile general information and statistics)

end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

FDC1

Protein name

RecName:		Full=Ferulic acid decarboxylase 1;
		EC 4.1.1.102;
AltName:		Full=Phenacrylate decarboxylase;

Gene name

FDC1

Comments [?]

Function	Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.
Catalytic activity	RHEA:33227: (E)-4-coumarate + H(+) = 4-hydroxystyrene + CO2 EC 4.1.1.102
	RHEA:46920: (E)-cinnamate + H(+) = CO2 + styrene EC 4.1.1.102
	RHEA:33807: (E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2 EC 4.1.1.102
Cofactor	Mn(2+)
	prenyl-FMN Note: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
Subunit	Homodimer. May form higher order oligomers.
Subcellular location	Cytoplasm.
Similarity	Belongs to the UbiD family. UbiD-like/FDC subfamily.

Keywords [?]

Cytoplasm
Decarboxylase
Lyase
Manganese
Metal-binding

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0016831; Molecular function: carboxy-lyase activity.
GO:0046281; Biological process: cinnamic acid catabolic process.
GO:0033494; Biological process: ferulate metabolic process.

Cross-references [?]

Pfam	PF01977; UbiD; 1;
TIGRFAMs	TIGR00148; TIGR00148; 1;

Features [?]

From: FDC1_YEAST (Q03034)

Key From To Description Tag Condition FTGroup

BINDING 170 175 /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746 [SN]-W-[SA]-[IV]-x-R

BINDING 192 193 /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746 Q-[HD]

ACT_SITE 285 285 Proton donor E

BINDING 170 170 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 N

BINDING 193 193 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 H

BINDING 236 236 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 E

BINDING 236 236 /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746 E

BINDING 394 394 /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746 K

Additional information [?]

Size range	494-549 amino acids
Related rules	None
Fusion	None

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