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HAMAP rule MF_03198

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General rule information [?]

Accession MF_03198
Dates 7-OCT-2015 (Created)
19-NOV-2022 (Last updated, Version 6)
Name Methyltr_EFM6
Scope
Eukaryota; Fungi
Template P53970 (EFM6_YEAST)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
EFM6
Protein name
RecName: Full=Protein-lysine N-methyltransferase ;
EC 2.1.1.-;
AltName: Full=Elongation factor methyltransferase 6;
Gene name
EFM6

Comments [?]

Function S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.
Subcellular location Cytoplasm.
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.

Keywords [?]

Cytoplasm
Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0016279; Molecular function: protein-lysine N-methyltransferase activity.
GO:0018022; Biological process: peptidyl-lysine methylation.

Cross-references [?]

Pfam PF10294; Methyltransf_16; 1;

Features [?]

From: EFM6_YEAST (P53970)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     87     89       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     G-[SA]-G  
BINDING     51     51       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     W  
BINDING     115     115       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     D  
BINDING     143     143       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     W  
BINDING     169     169       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [AGS]  

Additional information [?]

Size range 221-338 amino acids
Related rules None
Fusion None


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