HAMAP rule MF_03203

General rule information [?]

Accession	MF_03203
Dates	16-DEC-2013 (Created) 29-SEP-2022 (Last updated, Version 12)

Name	VLCF_elongase_3

Scope

Eukaryota; Vertebrata

Templates

Q9HB03 (ELOV3_HUMAN); O35949 (ELOV3_MOUSE): [Recover all]

Triggered by

HAMAP; MF_03203 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ELOV3

Protein name

RecName:		Full=Elongation of very long chain fatty acids protein 3;
		EC 2.3.1.199;
AltName:		Full=3-keto acyl-CoA synthase ;
AltName:		Full=ELOVL fatty acid elongase 3;
		Short=ELOVL FA elongase 3;
AltName:		Full=Very long chain 3-ketoacyl-CoA synthase 3;
AltName:		Full=Very long chain 3-oxoacyl-CoA synthase 3;

Gene name

ELOVL3

Comments [?]

Function	Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Catalytic activity	RHEA:32727: a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA EC 2.3.1.199
Pathway	Lipid metabolism; polyunsaturated fatty acid biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein.

case <FTTag:ERmotif>

Domain

The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

end case

Ptm	N-Glycosylated.
Similarity	Belongs to the ELO family. ELOVL3 subfamily.

Keywords [?]

Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Glycoprotein
Lipid biosynthesis
Lipid metabolism
Membrane
Transferase

Gene Ontology [?]

GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0016020; Cellular component: membrane.
GO:0009922; Molecular function: fatty acid elongase activity.
GO:0006636; Biological process: unsaturated fatty acid biosynthetic process.
GO:0019367; Biological process: fatty acid elongation, saturated fatty acid.
GO:0034625; Biological process: fatty acid elongation, monounsaturated fatty acid.
GO:0034626; Biological process: fatty acid elongation, polyunsaturated fatty acid.
GO:0035338; Biological process: long-chain fatty-acyl-CoA biosynthetic process.
GO:0042761; Biological process: very long-chain fatty acid biosynthetic process.

Cross-references [?]

PROSITE	PS00001; ASN_GLYCOSYLATION; 0-unlimited; trigger=PRU00498;
	PS01188; ELO; 1;
Pfam	PF01151; ELO; 1;

Computed features [?]

General	N_glycosylation; NetNGlyc; 0-unlimited; trigger=yes;
	Transmembrane; -; 7; trigger=yes;

Features [?]

From: ELOV3_HUMAN (Q9HB03)

Key From To Description Tag Condition FTGroup

MOTIF Cter-4 Cter Di-lysine motif ERmotif K-x-K-x(2)>

Additional information [?]

Size range	230-271 amino acids
Related rules	MF_03206 (ELOV6)
Fusion	None

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