Home  |  Contact
Annotation rule MF_03219
Send feedback

General rule information [?]

Accession MF_03219
Dates 20-OCT-2016 (Created)
20-NOV-2019 (Last updated, Version 5)
Name Succ_CoA_beta_euk
Templates P53312 (SUCB_YEAST); P0A836 (SUCC_ECOLI); P53590 (SUCB2_PIG): [Recover all]
case <OC:Eukaryota>
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial;
AltName: Full=Succinyl-CoA synthetase beta chain;

Comments [?]

Function Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
Catalytic activity RHEA:17661: ATP + CoA + succinate = ADP + phosphate + succinyl-CoA
case <FTGroup:1>
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.
end case
Pathway Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Subunit Heterodimer of an alpha and a beta subunit.
Subcellular location Mitochondrion.
Similarity Belongs to the succinate/malate CoA ligase beta subunit family.
case not <AnyFeature:TransitM>
Miscellaneous This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0004775; Molecular function: succinate-CoA ligase (ADP-forming) activity.
GO:0006099; Biological process: tricarboxylic acid cycle.

Cross-references [?]

PS50975; ATP_GRASP; 1;
Pfam PF08442; ATP-grasp_2; 1;
PF00549; Ligase_CoA; 1;
TIGRFAMs TIGR01016; sucCoAbeta; 1;
PIRSF PIRSF001554; SucCS_beta; 1;

Computed features [?]

General TransitM; -; 0-1; trigger=yes;

Features [?]

case <Feature:PS50975>
From: SUCC_ECOLI (P0A836)
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     9     244       ATP-grasp        
end case
NP_BIND     53     55       ATP     G-R-G  
REGION     321     323       Substrate binding; shared with subunit alpha     G-I-[VM]  
METAL     199     199       Magnesium     N   1
METAL     213     213       Magnesium     D   1
BINDING     46     46       ATP     K  
BINDING     107     107       ATP     E  
BINDING     264     264       Substrate; shared with subunit alpha     N  

Additional information [?]

Size range 367-542 amino acids
Related rules MF_03220 (SUCB1 supersedes the current rule); MF_03221 (SUCB2 supersedes the current rule)
Fusion None