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HAMAP rule MF_03219

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General rule information [?]

Accession MF_03219
Dates 20-OCT-2016 (Created)
1-JUN-2023 (Last updated, Version 9)
Name Succ_CoA_beta_euk
Scope(s) Eukaryota
Template(s) P53312 (SUCB_YEAST); P0A836 (SUCC_ECOLI); P53590 (SUCB2_PIG); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_00558 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SUCB
Protein name RecName: Full=Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial;
AltName: Full=Succinyl-CoA synthetase beta chain;

Comments [?]

FUNCTIONSuccinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
CATALYTIC ACTIVITY Reaction=ATP + CoA + succinate = ADP + phosphate + succinyl-CoA; Xref=Rhea:RHEA:17661, ChEBI:CHEBI:30031, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:456216; EC=;
case <FTGroup:1>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
end case
PATHWAYCarbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
SUBUNITHeterodimer of an alpha and a beta subunit.
SIMILARITYBelongs to the succinate/malate CoA ligase beta subunit family.
case not <AnyFeature:TransitM>
MISCELLANEOUSThis protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
case <FTGroup:1>
GO:0000287; Molecular function:magnesium ion binding
end case
GO:0004775; Molecular function:succinate-CoA ligase (ADP-forming) activity
GO:0006099; Biological process:tricarboxylic acid cycle

Cross-references [?]

Pfam PF08442; ATP-grasp_2; 1;
Pfam PF00549; Ligase_CoA; 1;
NCBIfam TIGR01016; sucCoAbeta; 1;
PIRSF PIRSF001554; SucCS_beta; 1;
General TransitM; -; 0-1;

Features [?]

From: SUCC_ECOLI (P0A836)
Key From To Description Tag Condition FTGroup
case <Feature:PS50975>
DOMAIN 9 244 /note="ATP-grasp"
end case
BINDING 53 55 /ligand="ATP"
BINDING 321 323 /ligand="substrate"
/ligand_note="ligand shared with subunit alpha"
BINDING 199 199 /ligand="Mg(2+)"
N 1
BINDING 213 213 /ligand="Mg(2+)"
D 1
BINDING 46 46 /ligand="ATP"
BINDING 107 107 /ligand="ATP"
BINDING 264 264 /ligand="substrate"
/ligand_note="ligand shared with subunit alpha"

Additional information [?]

Size range 367-542 amino acids
Related rules MF_03220
Fusion Nter: None Cter: None

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