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Annotation rule MF_03227
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General rule information [?]

Accession MF_03227
Dates 17-JUN-2019 (Created)
20-NOV-2019 (Last updated, Version 3)
Name But_acet_CoA_trans
Templates G2SYC0 (BCACT_ROSHA); B0MC58 (BCACT_ANACD): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Butyryl-CoA:acetate CoA-transferase;
Short=Butyryl-CoA CoA-transferase;
EC 2.8.3.-;

Comments [?]

Function Coenzyme A-transferase that converts butyryl-CoA to butyrate.
Catalytic activity RHEA:30071: acetyl-CoA + butanoate = acetate + butanoyl-CoA
PhysiologicalDirection=right-to-left (RHEA:30073)
Pathway Lipid metabolism; butanoate metabolism.
Similarity Belongs to the acetyl-CoA hydrolase/transferase family. Butyryl-CoA CoA-transferase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016740; Molecular function: transferase activity.
GO:0006084; Biological process: acetyl-CoA metabolic process.
GO:0046358; Biological process: butyrate biosynthetic process.

Cross-references [?]

Pfam PF13336; AcetylCoA_hyd_C; 1;
PF02550; AcetylCoA_hydro; 1;
TIGRFAMs TIGR03948; butyr_acet_CoA; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
REGION     220     224       Coenzyme A binding     G-x-G-x-M  
ACT_SITE     245     245       5-glutamyl coenzyme A thioester intermediate     E  
BINDING     320     320       Coenzyme A; via carbonyl oxygen     [ILVM]  
BINDING     343     343       Coenzyme A; via amide nitrogen     G  

Additional information [?]

Size range 443-453 amino acids
Related rules MF_03228 (BCT)
Fusion None
Comments The fermentation acid butyrate is of special interest, as it has been shown to serve as the preferred energy source for the gut wall and also influences cell differentiation and apoptosis in the colon, and this seems to aid in protection against colon cancer and inflammatory bowel disease. Formation of butyrate via butyryl-CoA CoA-transferase is the only available route for butyrate synthesis in the majority of human gut isolates.