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HAMAP rule MF_03227

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General rule information [?]

Accession MF_03227
Dates 17-JUN-2019 (Created)
1-JUN-2023 (Last updated, Version 7)
Name But_acet_CoA_trans
Scope(s) Bacteria
Template(s) G2SYC0 (BCACT_ROSHA); B0MC58 (BCACT_ANACD); [ Recover all ]
Triggered by HAMAP; MF_03227 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier BCACT
Protein name RecName: Full=Butyryl-CoA:acetate CoA-transferase;
                 Short=Butyryl-CoA CoA-transferase;

Comments [?]

FUNCTIONCoenzyme A-transferase that converts butyryl-CoA to butyrate.
CATALYTIC ACTIVITY Reaction=acetyl-CoA + butanoate = acetate + butanoyl-CoA; Xref=Rhea:RHEA:30071, ChEBI:CHEBI:17968, ChEBI:CHEBI:30089, ChEBI:CHEBI:57288, ChEBI:CHEBI:57371; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:30073;
PATHWAYLipid metabolism; butanoate metabolism.
SIMILARITYBelongs to the acetyl-CoA hydrolase/transferase family. Butyryl-CoA CoA-transferase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016740; Molecular function:transferase activity
GO:0006084; Biological process:acetyl-CoA metabolic process
GO:0046358; Biological process:butyrate biosynthetic process

Cross-references [?]

Pfam PF13336; AcetylCoA_hyd_C; 1;
Pfam PF02550; AcetylCoA_hydro; 1;
NCBIfam TIGR03948; butyr_acet_CoA; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 220 224 /ligand="CoA"
ACT_SITE 245 245 /note="5-glutamyl coenzyme A thioester intermediate" E
BINDING 320 320 /ligand="CoA"
BINDING 343 343 /ligand="CoA"

Additional information [?]

Size range 443-453 amino acids
Related rules MF_03228
Fusion Nter: None Cter: None
Comments The fermentation acid butyrate is of special interest, as it has been shown to serve as the preferred energy source for the gut wall and also influences cell differentiation and apoptosis in the colon, and this seems to aid in protection against colon cancer and inflammatory bowel disease. Formation of butyrate via butyryl-CoA CoA-transferase is the only available route for butyrate synthesis in the majority of human gut isolates.

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