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Annotation rule MF_03227 |
Accession | MF_03227 |
Dates | 17-JUN-2019 (Created) 20-NOV-2019 (Last updated, Version 3) |
Name | But_acet_CoA_trans |
Scope | Bacteria |
Templates | G2SYC0 (BCACT_ROSHA); B0MC58 (BCACT_ANACD): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Function | Coenzyme A-transferase that converts butyryl-CoA to butyrate. |
Catalytic activity | RHEA:30071: acetyl-CoA + butanoate = acetate + butanoyl-CoA
PhysiologicalDirection=right-to-left (RHEA:30073) |
Pathway | Lipid metabolism; butanoate metabolism. |
Similarity | Belongs to the acetyl-CoA hydrolase/transferase family. Butyryl-CoA CoA-transferase subfamily. |
Pfam | PF13336; AcetylCoA_hyd_C; 1; |
PF02550; AcetylCoA_hydro; 1; | |
TIGRFAMs | TIGR03948; butyr_acet_CoA; 1; |
From: BCACT_ROSHA (G2SYC0) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 220 | 224 | Coenzyme A binding | G-x-G-x-M | ||||||||
ACT_SITE | 245 | 245 | 5-glutamyl coenzyme A thioester intermediate | E | ||||||||
BINDING | 320 | 320 | Coenzyme A; via carbonyl oxygen | [ILVM] | ||||||||
BINDING | 343 | 343 | Coenzyme A; via amide nitrogen | G |
Size range | 443-453 amino acids |
Related rules | MF_03228 (BCT) |
Fusion | None |
Comments | The fermentation acid butyrate is of special interest, as it has been shown to serve as the preferred energy source for the gut wall and also influences cell differentiation and apoptosis in the colon, and this seems to aid in protection against colon cancer and inflammatory bowel disease. Formation of butyrate via butyryl-CoA CoA-transferase is the only available route for butyrate synthesis in the majority of human gut isolates. |