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HAMAP rule MF_03232

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General rule information [?]

Accession MF_03232
Dates 11-NOV-2020 (Created)
20-MAY-2021 (Last updated, Version 3)
Name YFT2
Scope
Eukaryota; Saccharomycetales
Template Q06676 (YFT2_YEAST)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
YFT2
case <FTGroup:1>
Protein name
RecName: Full=Acyl-coenzyme A diphosphatase YFT2;
EC 3.6.1.-;
AltName: Full=FIT family protein YFT2;
else
Identifier
YFT2
Protein name
RecName: Full=Acyl-coenzyme A diphosphatase YFT2 homolog;
AltName: Full=FIT family protein YFT2 homolog;
end case
Gene name
YFT2, FIT2A

Comments [?]

case <FTGroup:1>
Function Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization). Involved in phospholipid biosynthesis.
Catalytic activity RHEA:50044: an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)
PhysiologicalDirection=left-to-right (RHEA:50045)
RHEA:65564: (9Z)-octadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine
PhysiologicalDirection=left-to-right (RHEA:65565)
RHEA:65568: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine
PhysiologicalDirection=left-to-right (RHEA:65569)
RHEA:50032: H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine
PhysiologicalDirection=left-to-right (RHEA:50033)
else
Function May hydrolyze fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. May be required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis.
end case
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Similarity Belongs to the FIT family. Yeast FIT2A/YFT2 subfamily.

Keywords [?]

case <FTGroup:1>
Hydrolase
Lipid biosynthesis
Phospholipid biosynthesis
Phospholipid metabolism
end case
Endoplasmic reticulum
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

case <FTGroup:1>
GO:0016818; Molecular function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides.
end case
GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0140042; Biological process: lipid droplet formation.

Cross-references [?]

Pfam PF10261; Scs3p; 1;

Computed features [?]

General Transmembrane; -; 4-6;

Features [?]

From: YFT2_YEAST (Q06676)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     178     178             H   1
ACT_SITE     239     239             H   1

Additional information [?]

Size range 255-330 amino acids
Related rules None
Fusion None


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