HAMAP rule MF_03232
General rule information
[?]
Accession | MF_03232 |
Dates | 11-NOV-2020 (Created)
20-MAY-2021 (Last updated, Version 3) |
Name | YFT2 |
Scope(s) |
Eukaryota Saccharomycetales |
Template(s) | Q06676 (YFT2_YEAST); [ Recover all ] |
Triggered by |
HAMAP; MF_03232 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier | YFT2 |
case <FTGroup:1> | |
Protein name | RecName: Full=Acyl-coenzyme A diphosphatase YFT2; EC=3.6.1.-; AltName: Full=FIT family protein YFT2; |
else | |
Identifier | YFT2 |
Protein name | RecName: Full=Acyl-coenzyme A diphosphatase YFT2 homolog; AltName: Full=FIT family protein YFT2 homolog; |
end case | |
Gene name | Name=YFT2; Synonyms=FIT2A; |
Comments
[?]
case <FTGroup:1> | |
FUNCTION | Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'- bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization). Involved in phospholipid biosynthesis. |
CATALYTIC ACTIVITY | Reaction=an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'- phosphopantetheine + 2 H(+); Xref=Rhea:RHEA:50044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58342, ChEBI:CHEBI:58343, ChEBI:CHEBI:132023; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50045; |
CATALYTIC ACTIVITY | Reaction=(9Z)-octadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine; Xref=Rhea:RHEA:65564, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57387, ChEBI:CHEBI:58343, ChEBI:CHEBI:156553; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65565; |
CATALYTIC ACTIVITY | Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'- bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'- phosphopantetheine; Xref=Rhea:RHEA:65568, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57368, ChEBI:CHEBI:58343, ChEBI:CHEBI:156554; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65569; |
CATALYTIC ACTIVITY | Reaction=H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50032, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57379, ChEBI:CHEBI:58343, ChEBI:CHEBI:132018; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50033; |
else | |
FUNCTION | May hydrolyze fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'- bisphosphate. May be required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. |
end case | |
SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
SIMILARITY | Belongs to the FIT family. Yeast FIT2A/YFT2 subfamily. |
Keywords
[?]
case <FTGroup:1> | |
Hydrolase | |
Lipid biosynthesis | |
Phospholipid biosynthesis | |
Phospholipid metabolism | |
end case | |
Endoplasmic reticulum | |
Membrane | |
Transmembrane | |
Transmembrane helix |
Gene Ontology
[?]
case <FTGroup:1> | |
GO:0016818; Molecular function:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
end case | |
GO:0005789; Cellular component:endoplasmic reticulum membrane | |
GO:0140042; Biological process:lipid droplet formation |
Cross-references
[?]
Pfam | PF10261; Scs3p; 1; |
General | Transmembrane; -; 4-6; |
Features
[?]
From: YFT2_YEAST (Q06676) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 178 | 178 | H | 1 | ||||||||
ACT_SITE | 239 | 239 | H | 1 |
Additional information
[?]
Size range | 255-330 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |