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Annotation rule MF_04009
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General rule information [?]

Accession MF_04009
Dates 16-FEB-2016 (Created)
20-NOV-2019 (Last updated, Version 5)
Name HSV_AN
Scope
Viruses; Herpesviridae
Templates P04294 (AN_HHV11); Q2HR95 (AN_HHV8P); P03217 (AN_EBVB9): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
AN
case <OC:Gammaherpesvirinae>
Protein name
RecName: Full=Shutoff alkaline exonuclease;
Short=SOX;
EC 3.1.-.-;
else
Protein name
RecName: Full=Alkaline nuclease;
EC 3.1.-.-;
end case

Comments [?]

case <OC:Gammaherpesvirinae>
Function Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity. Also acts as a cytoplasmic RNA endonuclease that induces degradation of the majority of the cellular messenger RNAs during early lytic infection. The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and evasion from host immune response. Internally cleaves host mRNAs which are then degraded by the cellular exonuclease XRN1. Bypasses therefore the regulatory steps of deadenylation and decapping normally required for XRN1 activation.
else
Function Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity.
end case
case <OC:Gammaherpesvirinae>
Subunit Forms a complex with the DNA polymerase, the DNA polymerase processivity factor, and the major DNA binding protein.
else
Subunit Interacts with major DNA-binding protein; this interaction increases the nuclease processivity of the alkaline exonuclease.
end case
Subcellular location Host nucleus. Host cytoplasm.
Similarity Belongs to the herpesviridae alkaline nuclease family.

Keywords [?]


Gene Ontology [?]

case <OC:Gammaherpesvirinae>
GO:0030430; Cellular component: host cell cytoplasm.
GO:0042025; Cellular component: host cell nucleus.
GO:0003677; Molecular function: DNA binding.
GO:0004519; Molecular function: endonuclease activity.
GO:0004527; Molecular function: exonuclease activity.
GO:0004518; Molecular function: nuclease activity.
GO:0090305; Biological process: nucleic acid phosphodiester bond hydrolysis.
GO:0016032; Biological process: viral process.
GO:0003723; Molecular function: RNA binding.
GO:0039595; Biological process: induction by virus of catabolism of host mRNA.
GO:0039657; Biological process: suppression by virus of host gene expression.
else
GO:0030430; Cellular component: host cell cytoplasm.
GO:0042025; Cellular component: host cell nucleus.
GO:0003677; Molecular function: DNA binding.
GO:0004519; Molecular function: endonuclease activity.
GO:0004527; Molecular function: exonuclease activity.
GO:0004518; Molecular function: nuclease activity.
GO:0090305; Biological process: nucleic acid phosphodiester bond hydrolysis.
GO:0016032; Biological process: viral process.
end case

Cross-references [?]

Pfam PF01771; Herpes_alk_exo; 1;
PRINTS PR00924; ALKEXNUCLASE; 1;

Features [?]

From: AN_HHV11 (P04294)
Key     From     To       Description   Tag   Condition   FTGroup
SITE     280     280       Required for function     E  
SITE     340     340       Required for function     D  
SITE     364     364       Required for function     E  
SITE     366     366       Required for function     K  

Additional information [?]

Size range 470-626 amino acids
Related rules None
Fusion None