HAMAP rule MF_04009
General rule information
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| Accession | MF_04009 |
| Dates | 16-FEB-2016 (Created) 20-NOV-2019 (Last updated, Version 5) |
| Name | HSV_AN |
| Scope | Viruses; Herpesviridae |
| Templates | P04294 (AN_HHV11); Q2HR95 (AN_HHV8P); P03217 (AN_EBVB9): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
|
case <OC:Gammaherpesvirinae>
| Protein name |
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else
| Protein name |
|
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end case
Comments
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case <OC:Gammaherpesvirinae>
| Function | Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity. Also acts as a cytoplasmic RNA endonuclease that induces degradation of the majority of the cellular messenger RNAs during early lytic infection. The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and evasion from host immune response. Internally cleaves host mRNAs which are then degraded by the cellular exonuclease XRN1. Bypasses therefore the regulatory steps of deadenylation and decapping normally required for XRN1 activation. |
else
| Function | Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity. |
end case
case <OC:Gammaherpesvirinae>
| Subunit | Forms a complex with the DNA polymerase, the DNA polymerase processivity factor, and the major DNA binding protein. |
else
| Subunit | Interacts with major DNA-binding protein; this interaction increases the nuclease processivity of the alkaline exonuclease. |
end case
| Subcellular location | Host nucleus. Host cytoplasm. |
| Similarity | Belongs to the herpesviridae alkaline nuclease family. |
Keywords
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Gene Ontology
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case <OC:Gammaherpesvirinae>
GO:0030430; Cellular component: host cell cytoplasm.
GO:0042025; Cellular component: host cell nucleus.
GO:0003677; Molecular function: DNA binding.
GO:0004519; Molecular function: endonuclease activity.
GO:0004527; Molecular function: exonuclease activity.
GO:0004518; Molecular function: nuclease activity.
GO:0090305; Biological process: nucleic acid phosphodiester bond hydrolysis.
GO:0016032; Biological process: viral process.
GO:0003723; Molecular function: RNA binding.
GO:0039595; Biological process: induction by virus of catabolism of host mRNA.
GO:0039657; Biological process: suppression by virus of host gene expression.
GO:0042025; Cellular component: host cell nucleus.
GO:0003677; Molecular function: DNA binding.
GO:0004519; Molecular function: endonuclease activity.
GO:0004527; Molecular function: exonuclease activity.
GO:0004518; Molecular function: nuclease activity.
GO:0090305; Biological process: nucleic acid phosphodiester bond hydrolysis.
GO:0016032; Biological process: viral process.
GO:0003723; Molecular function: RNA binding.
GO:0039595; Biological process: induction by virus of catabolism of host mRNA.
GO:0039657; Biological process: suppression by virus of host gene expression.
else
GO:0030430; Cellular component: host cell cytoplasm.
GO:0042025; Cellular component: host cell nucleus.
GO:0003677; Molecular function: DNA binding.
GO:0004519; Molecular function: endonuclease activity.
GO:0004527; Molecular function: exonuclease activity.
GO:0004518; Molecular function: nuclease activity.
GO:0090305; Biological process: nucleic acid phosphodiester bond hydrolysis.
GO:0016032; Biological process: viral process.
GO:0042025; Cellular component: host cell nucleus.
GO:0003677; Molecular function: DNA binding.
GO:0004519; Molecular function: endonuclease activity.
GO:0004527; Molecular function: exonuclease activity.
GO:0004518; Molecular function: nuclease activity.
GO:0090305; Biological process: nucleic acid phosphodiester bond hydrolysis.
GO:0016032; Biological process: viral process.
end case
Cross-references
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Features
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| From: AN_HHV11 (P04294) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| SITE | 280 | 280 | Required for function | E | ||||||||
| SITE | 340 | 340 | Required for function | D | ||||||||
| SITE | 364 | 364 | Required for function | E | ||||||||
| SITE | 366 | 366 | Required for function | K | ||||||||
Additional information
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| Size range | 470-626 amino acids |
| Related rules | None |
| Fusion | None |