HAMAP rule MF_04009
General rule information
[?]
Accession | MF_04009 |
Dates | 16-FEB-2016 (Created)
1-MAR-2024 (Last updated, Version 7) |
Name | HSV_AN |
Scope(s) |
Viruses Herpesviridae |
Template(s) | P04294 (AN_HHV11); Q2HR95 (AN_HHV8P); P03217 (AN_EBVB9); [ Recover all ] |
Triggered by |
HAMAP; MF_04009 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier | AN |
case <OC:Gammaherpesvirinae> | |
Protein name | RecName: Full=Shutoff alkaline exonuclease; Short=SOX; EC=3.1.-.-; |
else | |
Protein name | RecName: Full=Alkaline nuclease; EC=3.1.-.-; |
end case |
Comments
[?]
case <OC:Gammaherpesvirinae> | |
FUNCTION | Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single- stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity. Also acts as a cytoplasmic RNA endonuclease that induces degradation of the majority of the cellular messenger RNAs during early lytic infection. The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and evasion from host immune response. Internally cleaves host mRNAs which are then degraded by the cellular exonuclease XRN1. Bypasses therefore the regulatory steps of deadenylation and decapping normally required for XRN1 activation. |
else | |
FUNCTION | Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single- stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity. |
end case | |
case <OC:Gammaherpesvirinae> | |
SUBUNIT | Forms a complex with the DNA polymerase, the DNA polymerase processivity factor, and the major DNA binding protein. |
else | |
SUBUNIT | Interacts with major DNA-binding protein; this interaction increases the nuclease processivity of the alkaline exonuclease. |
end case | |
SUBCELLULAR LOCATION | Host nucleus. Host cytoplasm. |
SIMILARITY | Belongs to the herpesviridae alkaline nuclease family. |
Keywords
[?]
Gene Ontology
[?]
case <OCellular component:Gammaherpesvirinae> | |
GO:0030430; Cellular component:host cell cytoplasm | |
GO:0042025; Cellular component:host cell nucleus | |
GO:0003677; Molecular function:DNA binding | |
GO:0004519; Molecular function:endonuclease activity | |
GO:0004527; Molecular function:exonuclease activity | |
GO:0004518; Molecular function:nuclease activity | |
GO:0090304; Biological process:nucleic acid metabolic process | |
GO:0016032; Biological process:viral process | |
GO:0003723; Molecular function:RNA binding | |
GO:0039595; Biological process:symbiont-mediated degradation of host mRNA | |
GO:0039657; Biological process:symbiont-mediated suppression of host gene expression | |
else; https://www.ebi.ac.uk/QuickGO/term/else | |
GO:0030430; Cellular component:host cell cytoplasm | |
GO:0042025; Cellular component:host cell nucleus | |
GO:0003677; Molecular function:DNA binding | |
GO:0004519; Molecular function:endonuclease activity | |
GO:0004527; Molecular function:exonuclease activity | |
GO:0004518; Molecular function:nuclease activity | |
GO:0090304; Biological process:nucleic acid metabolic process | |
GO:0016032; Biological process:viral process | |
end case |
Cross-references
[?]
Features
[?]
From: AN_HHV11 (P04294) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
SITE | 280 | 280 | /note="Required for function" | E | ||||||||
SITE | 340 | 340 | /note="Required for function" | D | ||||||||
SITE | 364 | 364 | /note="Required for function" | E | ||||||||
SITE | 366 | 366 | /note="Required for function" | K |
Additional information
[?]
Size range | 470-626 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |