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Annotation rule MF_04014
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General rule information [?]

Accession MF_04014
Dates 17-MAR-2016 (Created)
20-NOV-2019 (Last updated, Version 6)
Name HSV_TRM1
Scope
Viruses; Herpesviridae
Templates F5HC79 (TRM1_HCMVM); P10212 (TRM1_HHV11): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TRM1
Protein name
RecName: Full=Tripartite terminase subunit 1;
Gene name
TRM1

Comments [?]

Function Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.
Subunit Associates with TRM2 and TRM3 to form the tripartite terminase complex. Interacts with portal protein.
Subcellular location Host nucleus. Note=Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.
Similarity Belongs to the herpesviridae TRM1 protein family.

Keywords [?]

case <FTTag:Zinc>
end case

Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0016485; Biological process: protein processing.
GO:0019069; Biological process: viral capsid assembly.
GO:0019076; Biological process: viral release from host cell.

Cross-references [?]

Pfam PF01366; PRTP; 1;

Features [?]

From: TRM1_HCMVM (F5HC79)
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     191     219       C3H1-type   Zinc   C-x(2)-C-x(22)-C-x-H  
NP_BIND     709     716       ATP     [YF]-x(3)-[WYF]-x(3)  
MOTIF     822     827       Nuclear localization signal     R-K-R-P-R-R  

Additional information [?]

Size range 664-850 amino acids
Related rules None
Fusion None