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| Annotation rule MF_04014 |
General rule information
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| Accession | MF_04014 |
| Dates | 17-MAR-2016 (Created) 20-NOV-2019 (Last updated, Version 6) |
| Name | HSV_TRM1 |
| Scope | Viruses; Herpesviridae |
| Templates | F5HC79 (TRM1_HCMVM); P10212 (TRM1_HHV11): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes. |
| Subunit | Associates with TRM2 and TRM3 to form the tripartite terminase complex. Interacts with portal protein. |
| Subcellular location | Host nucleus. Note=Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions. |
| Similarity | Belongs to the herpesviridae TRM1 protein family. |
Keywords
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ATP-binding
Host nucleus
Late protein
Metal-binding
Nucleotide-binding
Viral genome packaging
Viral release from host cell
Host nucleus
Late protein
Metal-binding
Nucleotide-binding
Viral genome packaging
Viral release from host cell
case <FTTag:Zinc>
end case
Gene Ontology
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GO:0042025; Cellular component: host cell nucleus.
GO:0016485; Biological process: protein processing.
GO:0019069; Biological process: viral capsid assembly.
GO:0019076; Biological process: viral release from host cell.
GO:0016485; Biological process: protein processing.
GO:0019069; Biological process: viral capsid assembly.
GO:0019076; Biological process: viral release from host cell.
Cross-references
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| Pfam | PF01366; PRTP; 1; |
Features
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| From: TRM1_HCMVM (F5HC79) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ZN_FING | 191 | 219 | C3H1-type | Zinc | C-x(2)-C-x(22)-C-x-H | |||||||
| NP_BIND | 709 | 716 | ATP | [YF]-x(3)-[WYF]-x(3) | ||||||||
| MOTIF | 822 | 827 | Nuclear localization signal | R-K-R-P-R-R | ||||||||
Additional information
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| Size range | 664-850 amino acids |
| Related rules | None |
| Fusion | None |