HAMAP rule MF_04014

Accession	MF_04014
Dates	17-MAR-2016 (Created) 19-NOV-2022 (Last updated, Version 8)

Name

HSV_TRM1

Scope

Viruses; Herpesviridae

Templates

F5HC79 (TRM1_HCMVM); P10212 (TRM1_HHV11): [Recover all]

Triggered by

HAMAP; MF_04014 (Get profile general information and statistics)

Identifier

TRM1

Protein name

RecName: Full=Tripartite terminase subunit 1;

Gene name

TRM1

Function	Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.
Subunit	Associates with TRM2 and TRM3 to form the tripartite terminase complex. Interacts with portal protein.
Subcellular location	Host nucleus. Note=Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.
Similarity	Belongs to the herpesviridae TRM1 protein family.

ATP-binding
Host nucleus
Late protein
Metal-binding
Nucleotide-binding
Viral genome packaging
Viral release from host cell

Zinc
Zinc-finger

GO:0042025; Cellular component: host cell nucleus.
GO:0016485; Biological process: protein processing.
GO:0019069; Biological process: viral capsid assembly.
GO:0019076; Biological process: viral release from host cell.

Pfam	PF01366; PRTP; 1;

From: TRM1_HCMVM (F5HC79)

Key

From

To

Description

Tag

Condition

FTGroup

ZN_FING

191

219

C3H1-type

Zinc

C-x(2)-C-x(22)-C-x-H

BINDING

709

716

/ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

[YF]-x(3)-[WYF]-x(3)

MOTIF

822

827

Nuclear localization signal

R-K-R-P-R-R

Size range	664-850 amino acids
Related rules	None
Fusion	None

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