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HAMAP rule MF_04014

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General rule information [?]

Accession MF_04014
Dates 17-MAR-2016 (Created)
19-NOV-2022 (Last updated, Version 8)
Scope(s) Viruses
Template(s) F5HC79 (TRM1_HCMVM); P10212 (TRM1_HHV11); [ Recover all ]
Triggered by HAMAP; MF_04014 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TRM1
Protein name RecName: Full=Tripartite terminase subunit 1;
Gene name Name=TRM1;

Comments [?]

FUNCTIONComponent of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.
SUBUNITAssociates with TRM2 and TRM3 to form the tripartite terminase complex. Interacts with portal protein.
SUBCELLULAR LOCATIONHost nucleus. Note=Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.
SIMILARITYBelongs to the herpesviridae TRM1 protein family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus
GO:0016485; Biological process:protein processing
GO:0019069; Biological process:viral capsid assembly
GO:0019076; Biological process:viral release from host cell

Cross-references [?]

Pfam PF01366; PRTP; 1;

Features [?]

From: TRM1_HCMVM (F5HC79)
Key From To Description Tag Condition FTGroup
ZN_FING 191 219 /note="C3H1-type" Zinc C-x(2)-C-x(22)-C-x-H
BINDING 709 716 /ligand="ATP"
MOTIF 822 827 /note="Nuclear localization signal" R-K-R-P-R-R

Additional information [?]

Size range 664-850 amino acids
Related rules None
Fusion Nter: None Cter: None

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