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HAMAP rule MF_04015

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General rule information [?]

Accession MF_04015
Dates 21-MAR-2016 (Created)
20-NOV-2019 (Last updated, Version 5)
Scope(s) Viruses
Template(s) P10217 (TRM2_HHV11); [ Recover all ]
Triggered by HAMAP; MF_04015 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TRM2
Protein name RecName: Full=Tripartite terminase subunit 2;
Gene name Name=TRM2;

Comments [?]

FUNCTIONComponent of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid.
SUBUNITAssociates with TRM1 and TRM3 to form the tripartite terminase complex.
SUBCELLULAR LOCATIONHost nucleus. Note=Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.
SIMILARITYBelongs to the herpesviridae TRM2 protein family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus
GO:0019073; Biological process:viral DNA genome packaging
GO:0019076; Biological process:viral release from host cell

Cross-references [?]

Pfam PF03581; Herpes_UL33; 1;

Features [?]

Additional information [?]

Size range 80-233 amino acids
Related rules None
Fusion Nter: None Cter: None

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