HAMAP rule MF_04015
General rule information
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Accession | MF_04015 |
Dates | 21-MAR-2016 (Created)
20-NOV-2019 (Last updated, Version 5) |
Name | HSV_TRM2 |
Scope(s) |
Viruses Herpesviridae |
Template(s) | P10217 (TRM2_HHV11); [ Recover all ] |
Triggered by |
HAMAP; MF_04015 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | TRM2 |
Protein name | RecName: Full=Tripartite terminase subunit 2; |
Gene name | Name=TRM2; |
Comments
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FUNCTION | Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. |
SUBUNIT | Associates with TRM1 and TRM3 to form the tripartite terminase complex. |
SUBCELLULAR LOCATION | Host nucleus. Note=Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions. |
SIMILARITY | Belongs to the herpesviridae TRM2 protein family. |
Keywords
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Gene Ontology
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GO:0042025; Cellular component:host cell nucleus |
GO:0019073; Biological process:viral DNA genome packaging |
GO:0019076; Biological process:viral release from host cell |
Cross-references
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Pfam | PF03581; Herpes_UL33; 1; |
Features
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Additional information
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Size range | 80-233 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |