HAMAP rule MF_04015

Accession	MF_04015
Dates	21-MAR-2016 (Created) 20-NOV-2019 (Last updated, Version 5)

Name

HSV_TRM2

Scope

Viruses; Herpesviridae

Template

P10217 (TRM2_HHV11)

Triggered by

HAMAP; MF_04015 (Get profile general information and statistics)

Identifier

TRM2

Protein name

RecName: Full=Tripartite terminase subunit 2;

Gene name

TRM2

Function	Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid.
Subunit	Associates with TRM1 and TRM3 to form the tripartite terminase complex.
Subcellular location	Host nucleus. Note=Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.
Similarity	Belongs to the herpesviridae TRM2 protein family.

Host nucleus
Viral genome packaging
Viral release from host cell

GO:0042025; Cellular component: host cell nucleus.
GO:0019073; Biological process: viral DNA genome packaging.
GO:0019076; Biological process: viral release from host cell.

Pfam	PF03581; Herpes_UL33; 1;

Size range	80-233 amino acids
Related rules	None
Fusion	None

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