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HAMAP rule MF_04015

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General rule information [?]

Accession MF_04015
Dates 21-MAR-2016 (Created)
20-NOV-2019 (Last updated, Version 5)
Viruses; Herpesviridae
Template P10217 (TRM2_HHV11)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Tripartite terminase subunit 2;
Gene name

Comments [?]

Function Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid.
Subunit Associates with TRM1 and TRM3 to form the tripartite terminase complex.
Subcellular location Host nucleus. Note=Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.
Similarity Belongs to the herpesviridae TRM2 protein family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0019073; Biological process: viral DNA genome packaging.
GO:0019076; Biological process: viral release from host cell.

Cross-references [?]

Pfam PF03581; Herpes_UL33; 1;

Additional information [?]

Size range 80-233 amino acids
Related rules None
Fusion None