HAMAP rule MF_04015

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_04015
Accession	MF_04015
Dates	21-MAR-2016 (Created) 20-NOV-2019 (Last updated, Version 6)
Name	HSV_TRM2
Scope(s)	Viruses Herpesviridae
Template(s)	P10217; [ Recover all ]
Triggered by	HAMAP; MF_04015 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	TRM2
Protein name	RecName: Full=Tripartite terminase subunit 2;
Gene name	Name=TRM2;

Comments [?]

FUNCTION	Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid.
SUBUNIT	Associates with TRM1 and TRM3 to form the tripartite terminase complex.
SUBCELLULAR LOCATION	Host nucleus. Note=Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.
SIMILARITY	Belongs to the herpesviridae TRM2 protein family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus

GO:0019073; Biological process:viral DNA genome packaging

GO:0019076; Biological process:viral release from host cell

Cross-references [?]

Pfam	PF03581; Herpes_UL33; 1;

Features [?]

Additional information [?]