HAMAP rule MF_04025
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_04025 |
| Accession | MF_04025 |
| Dates | 22-APR-2016 (Created)
1-MAR-2024 (Last updated, Version 5) |
| Name | HSV_CVC2 |
| Scope(s) |
Viruses Herpesviridae |
| Template(s) | P10209 (CVC2_HHV11); [ Recover all ] |
| Triggered by |
HAMAP; MF_04025 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CVC2 |
| Protein name | RecName: Full=Capsid vertex component 2; |
| Gene name | Name=CVC2; |
Comments
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| FUNCTION | Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP. |
| SUBUNIT | Heterodimerizes with CVC1. Interacts with major capsid protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices. Interacts with the large tegument protein/LTP. |
| SUBCELLULAR LOCATION | Virion. Host nucleus. |
| SIMILARITY | Belongs to the herpesviridae CVC2 protein family. |
Keywords
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| Capsid protein |
| Host nucleus |
| Host-virus interaction |
| Viral genome packaging |
| Viral penetration into host nucleus |
| Virion |
| Virus entry into host cell |
| Viral release from host cell |
Gene Ontology
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| GO:0042025; Cellular component:host cell nucleus |
| GO:0019028; Cellular component:viral capsid |
| GO:0046718; Biological process:symbiont entry into host cell |
| GO:0019072; Biological process:viral genome packaging |
| GO:0075732; Biological process:viral penetration into host nucleus |
| GO:0019076; Biological process:viral release from host cell |
Cross-references
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| Pfam | PF01499; Herpes_UL25; 1; |
Features
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| From: CVC2_HHV11 (P10209) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | Nter | 50 | /note="Interaction with major capsid protein/MCP" | |||||||||
Additional information
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| Size range | 543-642 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |