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Annotation rule MF_04026
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General rule information [?]

Accession MF_04026
Dates 28-APR-2016 (Created)
20-NOV-2019 (Last updated, Version 4)
Name HSV_RIR1
Scope
Viruses; Alphaherpesvirinae
Viruses; Gammaherpesvirinae
Template P08543 (RIR1_HHV11)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RIR1
Protein name
RecName: Full=Ribonucleoside-diphosphate reductase large subunit;
Short=R1;
EC 1.17.4.1;
AltName: Full=Ribonucleotide reductase large subunit;
Gene name
RIR1

Comments [?]

Function Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Catalytic activity RHEA:23252: [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate
EC 1.17.4.1
Pathway Genetic information processing; DNA replication.
Subunit Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.
Similarity Belongs to the ribonucleoside diphosphate reductase large chain family.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004748; Molecular function: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor.
GO:0006260; Biological process: DNA replication.
GO:0016032; Biological process: viral process.

Cross-references [?]

PROSITE PS00089; RIBORED_LARGE; 1;
Pfam PF02867; Ribonuc_red_lgC; 1;
PF00317; Ribonuc_red_lgN; 1;
PRINTS PR01183; RIBORDTASEM1; 1;
TIGRFAMs TIGR02506; NrdE_NrdA; 1;

Features [?]

From: RIR1_HHV11 (P08543)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     581     582       Substrate binding     S-C  
REGION     791     795       Substrate binding     N-L-C-[TA]-E  
REGION     968     972       Substrate binding     P-T-x-x-[SCT]  
ACT_SITE     791     791       Proton acceptor     N  
ACT_SITE     793     793       Cysteine radical intermediate     C  
ACT_SITE     795     795       Proton acceptor     E  
BINDING     566     566       Substrate     T  
BINDING     612     612       Substrate; via amide nitrogen     G  
SITE     582     582       Important for hydrogen atom transfer     C  
SITE     808     808       Important for hydrogen atom transfer     C  
SITE     1111     1111       Important for electron transfer     Y  
SITE     1112     1112       Important for electron transfer     Y  
SITE     1132     1132       Interacts with thioredoxin/glutaredoxin     C  
SITE     1135     1135       Interacts with thioredoxin/glutaredoxin     C  
DISULFID     582     808       Redox-active     C-x*-C  

Additional information [?]

Size range 767-1144 amino acids
Related rules None
Fusion None