HAMAP rule MF_04026
General rule information
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| Accession | MF_04026 |
| Dates | 28-APR-2016 (Created)
2-SEP-2024 (Last updated, Version 9) |
| Name | HSV_RIR1 |
| Scope(s) |
Viruses Alphaherpesvirinae Gammaherpesvirinae |
| Template(s) | P08543 (RIR1_HHV11); [ Recover all ] |
| Triggered by |
HAMAP; MF_04026 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RIR1 |
| Protein name | RecName: Full=Ribonucleoside-diphosphate reductase large subunit; Short=R1; EC=1.17.4.1; AltName: Full=Ribonucleotide reductase large subunit; |
| Gene name | Name=RIR1; |
Comments
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| FUNCTION | Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. |
| CATALYTIC ACTIVITY | Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]- disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]- dithiol; Xref=Rhea:RHEA:23252, Rhea:RHEA-COMP:10698, Rhea:RHEA- COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57930, ChEBI:CHEBI:73316; EC=1.17.4.1; |
| SUBUNIT | Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n. |
| SIMILARITY | Belongs to the ribonucleoside diphosphate reductase large chain family. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0004748; Molecular function:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| GO:0016032; Biological process:viral process |
Cross-references
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| PROSITE | PS00089; RIBORED_LARGE; 1; |
| Pfam | PF02867; Ribonuc_red_lgC; 1; |
| Pfam | PF00317; Ribonuc_red_lgN; 1; |
| PRINTS | PR01183; RIBORDTASEM1; 1; |
| NCBIfam | TIGR02506; NrdE_NrdA; 1; |
Features
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| From: RIR1_HHV11 (P08543) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 581 | 582 | /ligand="substrate" | S-C | ||||||||
| BINDING | 791 | 795 | /ligand="substrate" | N-L-C-[TA]-E | ||||||||
| BINDING | 968 | 972 | /ligand="substrate" | P-T-x-x-[SCT] | ||||||||
| ACT_SITE | 791 | 791 | /note="Proton acceptor" | N | ||||||||
| ACT_SITE | 793 | 793 | /note="Cysteine radical intermediate" | C | ||||||||
| ACT_SITE | 795 | 795 | /note="Proton acceptor" | E | ||||||||
| BINDING | 566 | 566 | /ligand="substrate" | T | ||||||||
| BINDING | 612 | 612 | /ligand="substrate" | G | ||||||||
| SITE | 582 | 582 | /note="Important for hydrogen atom transfer" | C | ||||||||
| SITE | 808 | 808 | /note="Important for hydrogen atom transfer" | C | ||||||||
| SITE | 1111 | 1111 | /note="Important for electron transfer" | Y | ||||||||
| SITE | 1112 | 1112 | /note="Important for electron transfer" | Y | ||||||||
| SITE | 1132 | 1132 | /note="Interacts with thioredoxin/glutaredoxin" | C | ||||||||
| SITE | 1135 | 1135 | /note="Interacts with thioredoxin/glutaredoxin" | C | ||||||||
| DISULFID | 582 | 808 | /note="Redox-active" | C-x*-C | ||||||||
Additional information
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| Size range | 767-1144 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |