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HAMAP rule MF_04026

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General rule information [?]

Accession MF_04026
Dates 28-APR-2016 (Created)
16-OCT-2023 (Last updated, Version 8)
Scope(s) Viruses
Template(s) P08543 (RIR1_HHV11); [ Recover all ]
Triggered by HAMAP; MF_04026 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RIR1
Protein name RecName: Full=Ribonucleoside-diphosphate reductase large subunit;
AltName: Full=Ribonucleotide reductase large subunit;
Gene name Name=RIR1;

Comments [?]

FUNCTIONRibonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
CATALYTIC ACTIVITY Reaction=[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'- diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'- diphosphate; Xref=Rhea:RHEA:23252, Rhea:RHEA-COMP:10698, Rhea:RHEA- COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57930, ChEBI:CHEBI:73316; EC=;
SUBUNITHeterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.
SIMILARITYBelongs to the ribonucleoside diphosphate reductase large chain family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004748; Molecular function:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0016032; Biological process:viral process

Cross-references [?]

Pfam PF02867; Ribonuc_red_lgC; 1;
Pfam PF00317; Ribonuc_red_lgN; 1;
NCBIfam TIGR02506; NrdE_NrdA; 1;

Features [?]

From: RIR1_HHV11 (P08543)
Key From To Description Tag Condition FTGroup
BINDING 581 582 /ligand="substrate" S-C
BINDING 791 795 /ligand="substrate" N-L-C-[TA]-E
BINDING 968 972 /ligand="substrate" P-T-x-x-[SCT]
ACT_SITE 791 791 /note="Proton acceptor" N
ACT_SITE 793 793 /note="Cysteine radical intermediate" C
ACT_SITE 795 795 /note="Proton acceptor" E
BINDING 566 566 /ligand="substrate" T
BINDING 612 612 /ligand="substrate" G
SITE 582 582 /note="Important for hydrogen atom transfer" C
SITE 808 808 /note="Important for hydrogen atom transfer" C
SITE 1111 1111 /note="Important for electron transfer" Y
SITE 1112 1112 /note="Important for electron transfer" Y
SITE 1132 1132 /note="Interacts with thioredoxin/glutaredoxin" C
SITE 1135 1135 /note="Interacts with thioredoxin/glutaredoxin" C
DISULFID 582 808 /note="Redox-active" C-x*-C

Additional information [?]

Size range 767-1144 amino acids
Related rules None
Fusion Nter: None Cter: None

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