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Annotation rule MF_04028 |
General rule information
[?]
Accession |
MF_04028 |
Dates |
28-APR-2016 (Created) 20-NOV-2019 (Last updated, Version 6) |
Scope |
Viruses; Herpesviridae |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=Ribonucleoside-diphosphate reductase small subunit;
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EC 1.17.4.1;
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AltName:
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Full=Ribonucleotide reductase small subunit;
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Function |
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. |
Catalytic activity |
RHEA:23252: [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate
EC 1.17.4.1
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Cofactor |
Fe cation |
Pathway |
Genetic information processing; DNA replication. |
Subunit |
Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n. |
case <Feature:Transmembrane==1>
Subcellular location |
Host membrane; Single-pass membrane protein. |
end case
Similarity |
Belongs to the ribonucleoside diphosphate reductase small chain family. |
case <Feature:Transmembrane==1>
end case
case <Feature:Transmembrane==1>
GO:0033644; Cellular component: host cell membrane.
GO:0016021; Cellular component: integral component of membrane.
end case
GO:0046872; Molecular function: metal ion binding.
GO:0004748; Molecular function: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor.
GO:0009186; Biological process: deoxyribonucleoside diphosphate metabolic process.
GO:0006260; Biological process: DNA replication.
General |
Transmembrane; -; 0-1; trigger=yes; |
From: RIR2_EBVG (P0C701) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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98
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98
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Y
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METAL
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61
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61
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Iron 1
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[ED]
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METAL
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91
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91
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Iron 1
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E
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METAL
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91
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91
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Iron 2
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E
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METAL
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94
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94
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Iron 1
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H
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METAL
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154
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154
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Iron 2
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E
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METAL
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188
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188
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Iron 2
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E
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METAL
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191
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191
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Iron 2
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H
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Additional information
[?]
Size range |
302-343 amino acids |
Related rules |
None |
Fusion |
None |