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Annotation rule MF_04028
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General rule information [?]

Accession MF_04028
Dates 28-APR-2016 (Created)
20-NOV-2019 (Last updated, Version 6)
Name HSV_RIR2
Scope
Viruses; Herpesviridae
Template P0C701 (RIR2_EBVG)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RIR2
Protein name
RecName: Full=Ribonucleoside-diphosphate reductase small subunit;
EC 1.17.4.1;
AltName: Full=Ribonucleotide reductase small subunit;
Gene name
RIR2

Comments [?]

Function Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Catalytic activity RHEA:23252: [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate
EC 1.17.4.1
Cofactor Fe cation
Pathway Genetic information processing; DNA replication.
Subunit Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.
case <Feature:Transmembrane==1>
Subcellular location Host membrane; Single-pass membrane protein.
end case
Similarity Belongs to the ribonucleoside diphosphate reductase small chain family.

Keywords [?]

case <Feature:Transmembrane==1>
end case

Gene Ontology [?]

case <Feature:Transmembrane==1>
GO:0033644; Cellular component: host cell membrane.
GO:0016021; Cellular component: integral component of membrane.
end case
GO:0046872; Molecular function: metal ion binding.
GO:0004748; Molecular function: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor.
GO:0009186; Biological process: deoxyribonucleoside diphosphate metabolic process.
GO:0006260; Biological process: DNA replication.

Cross-references [?]

PROSITE PS00368; RIBORED_SMALL; 1;
Pfam PF00268; Ribonuc_red_sm; 1;

Computed features [?]

General Transmembrane; -; 0-1; trigger=yes;

Features [?]

From: RIR2_EBVG (P0C701)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     98     98             Y  
METAL     61     61       Iron 1     [ED]  
METAL     91     91       Iron 1     E  
METAL     91     91       Iron 2     E  
METAL     94     94       Iron 1     H  
METAL     154     154       Iron 2     E  
METAL     188     188       Iron 2     E  
METAL     191     191       Iron 2     H  

Additional information [?]

Size range 302-343 amino acids
Related rules None
Fusion None