HAMAP rule MF_04028
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_04028 |
| Accession | MF_04028 |
| Dates | 28-APR-2016 (Created)
2-SEP-2024 (Last updated, Version 11) |
| Name | HSV_RIR2 |
| Scope(s) |
Viruses Herpesviridae |
| Template(s) | P0C701 (RIR2_EBVG); [ Recover all ] |
| Triggered by |
HAMAP; MF_04028 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RIR2 |
| Protein name | RecName: Full=Ribonucleoside-diphosphate reductase small subunit; EC=1.17.4.1; AltName: Full=Ribonucleotide reductase small subunit; |
| Gene name | Name=RIR2; |
Comments
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| FUNCTION | Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. |
| CATALYTIC ACTIVITY | Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]- disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]- dithiol; Xref=Rhea:RHEA:23252, Rhea:RHEA-COMP:10698, Rhea:RHEA- COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57930, ChEBI:CHEBI:73316; EC=1.17.4.1; |
| COFACTOR | Name=Fe cation; Xref=ChEBI:CHEBI:24875; |
| SUBUNIT | Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n. |
| case <Feature:Transmembrane==1> | |
| SUBCELLULAR LOCATION | Host membrane; Single-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the ribonucleoside diphosphate reductase small chain family. |
Keywords
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| Iron | |
| Metal-binding | |
| Oxidoreductase | |
| case <Feature:Transmembrane==1> | |
| Host membrane | |
| Membrane | |
| Transmembrane | |
| Transmembrane helix | |
| end case | |
Gene Ontology
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| case <Feature:Transmembrane==1> | |
| GO:0033644; Cellular component:host cell membrane | |
| GO:0016020; Cellular component:membrane | |
| end case | |
| GO:0046872; Molecular function:metal ion binding | |
| GO:0004748; Molecular function:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | |
| GO:0009186; Biological process:deoxyribonucleoside diphosphate metabolic process | |
Cross-references
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| PROSITE | PS00368; RIBORED_SMALL; 1; |
| Pfam | PF00268; Ribonuc_red_sm; 1; |
| General | Transmembrane; -; 0-1; |
Features
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| From: RIR2_EBVG (P0C701) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 98 | 98 | Y | |||||||||
| BINDING | 61 | 61 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" |
[ED] | ||||||||
| BINDING | 91 | 91 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" |
E | ||||||||
| BINDING | 91 | 91 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2" |
E | ||||||||
| BINDING | 94 | 94 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" |
H | ||||||||
| BINDING | 154 | 154 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2" |
E | ||||||||
| BINDING | 188 | 188 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2" |
E | ||||||||
| BINDING | 191 | 191 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2" |
H | ||||||||
Additional information
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| Size range | 302-343 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |