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| Annotation rule MF_04028 |
General rule information
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| Accession | MF_04028 |
| Dates | 28-APR-2016 (Created) 20-NOV-2019 (Last updated, Version 6) |
| Name | HSV_RIR2 |
| Scope | Viruses; Herpesviridae |
| Template | P0C701 (RIR2_EBVG) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. |
| Catalytic activity | RHEA:23252: [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate
EC 1.17.4.1 |
| Cofactor | Fe cation |
| Pathway | Genetic information processing; DNA replication. |
| Subunit | Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n. |
case <Feature:Transmembrane==1>
| Subcellular location | Host membrane; Single-pass membrane protein. |
end case
| Similarity | Belongs to the ribonucleoside diphosphate reductase small chain family. |
Keywords
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case <Feature:Transmembrane==1>
end case
Gene Ontology
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case <Feature:Transmembrane==1>
GO:0033644; Cellular component: host cell membrane.
GO:0016021; Cellular component: integral component of membrane.
GO:0016021; Cellular component: integral component of membrane.
end case
GO:0046872; Molecular function: metal ion binding.
GO:0004748; Molecular function: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor.
GO:0009186; Biological process: deoxyribonucleoside diphosphate metabolic process.
GO:0006260; Biological process: DNA replication.
GO:0004748; Molecular function: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor.
GO:0009186; Biological process: deoxyribonucleoside diphosphate metabolic process.
GO:0006260; Biological process: DNA replication.
Cross-references
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Computed features
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| General | Transmembrane; -; 0-1; trigger=yes; |
Features
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| From: RIR2_EBVG (P0C701) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 98 | 98 | Y | |||||||||
| METAL | 61 | 61 | Iron 1 | [ED] | ||||||||
| METAL | 91 | 91 | Iron 1 | E | ||||||||
| METAL | 91 | 91 | Iron 2 | E | ||||||||
| METAL | 94 | 94 | Iron 1 | H | ||||||||
| METAL | 154 | 154 | Iron 2 | E | ||||||||
| METAL | 188 | 188 | Iron 2 | E | ||||||||
| METAL | 191 | 191 | Iron 2 | H | ||||||||
Additional information
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| Size range | 302-343 amino acids |
| Related rules | None |
| Fusion | None |