HAMAP rule MF_04036
General rule information
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Accession | MF_04036 |
Dates | 9-SEP-2016 (Created)
11-JUL-2023 (Last updated, Version 6) |
Name | HSV_GL_betahv |
Scope(s) |
Viruses Betaherpesvirinae |
Template(s) | P16832 (GL_HCMVA); P52508 (GL_HHV6U); [ Recover all ] |
Triggered by |
HAMAP; MF_04036 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GL |
Protein name | RecName: Full=Envelope glycoprotein L; Short=gL; |
Gene name | Name=gL; |
Comments
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FUNCTION | The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. |
SUBUNIT | Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. |
SUBCELLULAR LOCATION | Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs. |
Keywords
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Gene Ontology
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GO:0020002; Cellular component:host cell plasma membrane |
GO:0019031; Cellular component:viral envelope |
GO:0055036; Cellular component:virion membrane |
GO:0019064; Biological process:fusion of virus membrane with host plasma membrane |
Cross-references
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Features
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Additional information
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Size range | 246-278 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |