Home  |  Contact
Annotation rule MF_04036
Send feedback

General rule information [?]

Accession MF_04036
Dates 9-SEP-2016 (Created)
20-NOV-2019 (Last updated, Version 5)
Name HSV_GL_betahv
Scope
Viruses; Betaherpesvirinae
Templates P16832 (GL_HCMVA); P52508 (GL_HHV6U): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GL
Protein name
RecName: Full=Envelope glycoprotein L;
Short=gL;
Gene name
gL

Comments [?]

Function The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.
Subunit Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH.
Subcellular location Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.
Similarity Belongs to the herpesviridae glycoprotein L family.

Keywords [?]


Gene Ontology [?]

GO:0020002; Cellular component: host cell plasma membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.

Cross-references [?]

Pfam PF01801; Cytomega_gL; 1;

Computed features [?]

General Signal; -; 0-1; trigger=yes;

Additional information [?]

Size range 246-278 amino acids
Related rules None
Fusion None