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HAMAP rule MF_04040

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General rule information [?]

Accession MF_04040
Dates 22-SEP-2016 (Created)
20-NOV-2019 (Last updated, Version 5)
Name HSV_CEP3_alphahv
Scope(s) Viruses
Template(s) P04289 (CEP3_HHV11); [ Recover all ]
Triggered by HAMAP; MF_04040 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CEP3
Protein name RecName: Full=Cytoplasmic envelopment protein 3;

Comments [?]

FUNCTIONPlays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.
SUBUNITInteracts with cytoplasmic envelopment protein 2; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus.
SUBCELLULAR LOCATIONVirion tegument. Virion membrane; Lipid-anchor. Host cell membrane; Lipid-anchor; Cytoplasmic side. Host Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
PTMMyristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.
PTMPhosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.
SIMILARITYBelongs to the herpesviridae cytoplasmic envelopment protein 3 family.

Keywords [?]

Gene Ontology [?]

GO:0044178; Cellular component:host cell Golgi membrane
GO:0020002; Cellular component:host cell plasma membrane
GO:0019033; Cellular component:viral tegument
GO:0055036; Cellular component:virion membrane
GO:0009653; Biological process:anatomical structure morphogenesis
GO:0046760; Biological process:viral budding from Golgi membrane

Cross-references [?]

Pfam PF11094; UL11; 1;
PIRSF PIRSF003496; Myristoylat_tegument_UL11; 1;

Features [?]

From: CEP3_HHV11 (P04289)
Key From To Description Tag Condition FTGroup
INIT_MET 1 1 /note="Removed; by host" M
REGION 37 43 /note="Asp/Glu-rich (acidic)"
MOTIF 18 19 /note="Di-leucine-like internalization motif" L-[IV]
MOD_RES 40 40 /note="Phosphoserine" S
LIPID 2 2 /note="N-myristoyl glycine; by host" G

Additional information [?]

Size range 47-96 amino acids
Related rules None
Fusion Nter: None Cter: None

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