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HAMAP rule MF_04040

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General rule information [?]

Accession MF_04040
Dates 22-SEP-2016 (Created)
20-NOV-2019 (Last updated, Version 5)
Name HSV_CEP3_alphahv
Viruses; Alphaherpesvirinae
Template P04289 (CEP3_HHV11)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Cytoplasmic envelopment protein 3;

Comments [?]

Function Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.
Subunit Interacts with cytoplasmic envelopment protein 2; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus.
Subcellular location Virion tegument. Virion membrane; Lipid-anchor. Host cell membrane; Lipid-anchor; Cytoplasmic side. Host Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Ptm Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.
Phosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.
Similarity Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.

Keywords [?]

Gene Ontology [?]

GO:0044178; Cellular component: host cell Golgi membrane.
GO:0020002; Cellular component: host cell plasma membrane.
GO:0019033; Cellular component: viral tegument.
GO:0055036; Cellular component: virion membrane.
GO:0009653; Biological process: anatomical structure morphogenesis.
GO:0046760; Biological process: viral budding from Golgi membrane.

Cross-references [?]

Pfam PF11094; UL11; 1;
PIRSF PIRSF003496; Myristoylat_tegument_UL11; 1;

Features [?]

From: CEP3_HHV11 (P04289)
Key     From     To       Description   Tag   Condition   FTGroup
INIT_MET     1     1       Removed; by host     M  
REGION     37     43       Asp/Glu-rich (acidic)        
MOTIF     18     19       Di-leucine-like internalization motif     L-[IV]  
MOD_RES     40     40       Phosphoserine     S  
LIPID     2     2       N-myristoyl glycine; by host     G  

Additional information [?]

Size range 47-96 amino acids
Related rules None
Fusion None