HAMAP rule MF_04040

Accession	MF_04040
Dates	22-SEP-2016 (Created) 20-NOV-2019 (Last updated, Version 5)

Name	HSV_CEP3_alphahv

Scope

Viruses; Alphaherpesvirinae

Template

P04289 (CEP3_HHV11)

Triggered by

HAMAP; MF_04040 (Get profile general information and statistics)

Identifier

CEP3

Protein name

RecName: Full=Cytoplasmic envelopment protein 3;

Function	Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.
Subunit	Interacts with cytoplasmic envelopment protein 2; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus.
Subcellular location	Virion tegument. Virion membrane; Lipid-anchor. Host cell membrane; Lipid-anchor; Cytoplasmic side. Host Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Ptm	Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.
	Phosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.
Similarity	Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.

Host cell membrane
Host Golgi apparatus
Host membrane
Lipoprotein
Membrane
Myristate
Palmitate
Phosphoprotein
Virion
Virion tegument

GO:0044178; Cellular component: host cell Golgi membrane.
GO:0020002; Cellular component: host cell plasma membrane.
GO:0019033; Cellular component: viral tegument.
GO:0055036; Cellular component: virion membrane.
GO:0009653; Biological process: anatomical structure morphogenesis.
GO:0046760; Biological process: viral budding from Golgi membrane.

Pfam	PF11094; UL11; 1;
PIRSF	PIRSF003496; Myristoylat_tegument_UL11; 1;

From: CEP3_HHV11 (P04289)

Key

From

To

Description

Tag

Condition

FTGroup

INIT_MET

1

1

Removed; by host

M

REGION

37

43

Asp/Glu-rich (acidic)

MOTIF

18

19

Di-leucine-like internalization motif

L-[IV]

MOD_RES

40

40

Phosphoserine

S

LIPID

2

2

N-myristoyl glycine; by host

G

Size range	47-96 amino acids
Related rules	None
Fusion	None

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