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HAMAP rule MF_04050

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General rule information [?]

Accession MF_04050
Dates 6-MAR-2017 (Created)
20-NOV-2019 (Last updated, Version 3)
Viruses; Adenoviridae
Template P03284 (CAP9_ADE12)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Hexon-interlacing protein;
AltName: Full=Protein IX;
Gene name

Comments [?]

Function Structural component of the virion that acts as a cement protein on the capsid exterior and forms triskelion structures consisting of three molecules that stabilize three hexon trimers at the center of each icosahedral facet and fixes the peripentonal hexons. Dispensable for assembly. During virus entry, recruits the anterograde motor kinesin-1 to the capsid docked at the nuclear pore complex thereby subjecting the docked capsid to a pulling force. The resulting tension leads to capsid disruption, dispersion of capsid fragments toward cell periphery and eventually viral DNA entry into the host nucleus.
Subunit Homotrimer. Interacts with hexon protein; this interaction tethers the hexons together. Self-interacts with adjacent proteins. Interacts with kinesin light chain KLC1; this interaction leads to capsid disruption at the nuclear pore complex during virus entry into host cell.
Subcellular location Virion. Host nucleus. Note=Located in the canyons between the hexons on the outer surface of the capsid. Forms a sort of hairnet on the outer side of the virion. Present in 240 copies per virion.
Induction Expressed in the intermediate phase of the viral replicative cycle.
Domain Three N-terminal domains of hexon-interlacing protein form triskelions between hexon capsomers.
Miscellaneous This protein is only encoded by mastadenoviruses, and may therefore play a role in mammals tropism.
Similarity Belongs to the adenoviridae hexon-interlacing protein family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0098021; Cellular component: viral capsid, decoration.
GO:0046718; Biological process: viral entry into host cell.

Cross-references [?]

Pfam PF03955; Adeno_PIX; 1;

Computed features [?]

General Coiled_coil; -; 1-unlimited; trigger=yes;

Additional information [?]

Size range 103-144 amino acids
Related rules None
Fusion None