HAMAP rule MF_04050

General rule information [?]

Accession	MF_04050
Dates	6-MAR-2017 (Created) 20-NOV-2019 (Last updated, Version 3)
Name	ADV_CAP9
Scope(s)	Viruses Adenoviridae
Template(s)	P03284 (CAP9_ADE12); [ Recover all ]
Triggered by	HAMAP; MF_04050 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	CAP9
Protein name	RecName: Full=Hexon-interlacing protein; AltName: Full=Protein IX;
Gene name	Name=IX;

Comments [?]

FUNCTION	Structural component of the virion that acts as a cement protein on the capsid exterior and forms triskelion structures consisting of three molecules that stabilize three hexon trimers at the center of each icosahedral facet and fixes the peripentonal hexons. Dispensable for assembly. During virus entry, recruits the anterograde motor kinesin-1 to the capsid docked at the nuclear pore complex thereby subjecting the docked capsid to a pulling force. The resulting tension leads to capsid disruption, dispersion of capsid fragments toward cell periphery and eventually viral DNA entry into the host nucleus.
SUBUNIT	Homotrimer. Interacts with hexon protein; this interaction tethers the hexons together. Self-interacts with adjacent proteins. Interacts with kinesin light chain KLC1; this interaction leads to capsid disruption at the nuclear pore complex during virus entry into host cell.
SUBCELLULAR LOCATION	Virion. Host nucleus. Note=Located in the canyons between the hexons on the outer surface of the capsid. Forms a sort of hairnet on the outer side of the virion. Present in 240 copies per virion.
INDUCTION	Expressed in the intermediate phase of the viral replicative cycle.
DOMAIN	Three N-terminal domains of hexon-interlacing protein form triskelions between hexon capsomers.
MISCELLANEOUS	This protein is only encoded by mastadenoviruses, and may therefore play a role in mammals tropism.
SIMILARITY	Belongs to the adenoviridae hexon-interlacing protein family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus

GO:0098021; Cellular component:viral capsid, decoration

GO:0046718; Biological process:viral entry into host cell

Cross-references [?]

Pfam	PF03955; Adeno_PIX; 1;
General	Coiled_coil; -; 1-unlimited;

Features [?]

Additional information [?]