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HAMAP rule MF_04051
General rule information
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| Accession | MF_04051 |
| Dates | 9-MAR-2017 (Created)
1-MAR-2024 (Last updated, Version 5) |
| Name | ADV_CAPSH |
| Scope(s) |
Viruses Adenoviridae |
| Template(s) | P04133 (CAPSH_ADE05); [ Recover all ] |
| Triggered by |
HAMAP; MF_04051 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CAPSH |
| Protein name | RecName: Full=Hexon protein; Short=CP-H; AltName: Full=Protein II; |
| Gene name | Name=L3; |
Comments
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| FUNCTION | Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus. |
| SUBUNIT | Homotrimer. Interacts with the capsid vertex protein; this interaction binds the peripentonal hexons to the neighboring penton base. Interacts with the hexon-linking protein; this interaction tethers the hexons surrounding the penton to those situated in the central plate of the facet. Interacts with the hexon-interlacing protein; this interaction lashes the hexons together. Interacts with host dyneins DYNC1LI1 and DYNC1I2; this interaction might be involved in intracellular microtubule-dependent transport of incoming viral capsid. Interacts with the shutoff protein; this interaction allows folding and formation of hexons trimers. Interacts with pre-protein VI; this interaction probably allows nuclear import of hexon trimers and possibly pre-capsid assembly. |
| SUBCELLULAR LOCATION | Virion. Host nucleus. Note=Forms the capsid icosahedric shell. Present in 720 copies per virion, assembled in 240 trimers. |
| INDUCTION | Expressed in the late phase of the viral replicative cycle. |
| MISCELLANEOUS | All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell. |
| SIMILARITY | Belongs to the adenoviridae hexon protein family. |
Keywords
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Gene Ontology
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| GO:0042025; Cellular component:host cell nucleus |
| GO:0039623; Cellular component:T=25 icosahedral viral capsid |
| GO:0019028; Cellular component:viral capsid |
| GO:0005198; Molecular function:structural molecule activity |
| GO:0075521; Biological process:microtubule-dependent intracellular transport of viral material towards nucleus |
| GO:0046718; Biological process:symbiont entry into host cell |
Cross-references
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Features
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| From: CAPSH_ADE05 (P04133) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| INIT_MET | 1 | 1 | /note="Removed; by host" | M | 1 | |||||||
| case <FTGroup:1> | ||||||||||||
| CHAIN | 2 | Cter | /note="Hexon protein" | |||||||||
| end case | ||||||||||||
| case not <FTGroup:1> | ||||||||||||
| CHAIN | Nter | Cter | /note="Hexon protein" | |||||||||
| end case | ||||||||||||
| SITE | 777 | 777 | /note="Involved in interaction with pre-protein VI" | G | ||||||||
| MOD_RES | 2 | 2 | /note="N-acetylalanine; by host" | Acet | A | |||||||
| MOD_RES | 175 | 175 | /note="Phosphoserine; by host" | S | ||||||||
| MOD_RES | 940 | 940 | /note="Phosphotyrosine; by host" | Y | ||||||||
Additional information
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| Size range | 905-968 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |