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Annotation rule MF_04051
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General rule information [?]

Accession MF_04051
Dates 9-MAR-2017 (Created)
20-NOV-2019 (Last updated, Version 4)
Viruses; Adenoviridae
Template P04133 (CAPSH_ADE05)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Hexon protein;
AltName: Full=Protein II;
Gene name

Comments [?]

Function Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.
Subunit Homotrimer. Interacts with the capsid vertex protein; this interaction binds the peripentonal hexons to the neighboring penton base. Interacts with the hexon-linking protein; this interaction tethers the hexons surrounding the penton to those situated in the central plate of the facet. Interacts with the hexon-interlacing protein; this interaction lashes the hexons together. Interacts with host dyneins DYNC1LI1 and DYNC1I2; this interaction might be involved in intracellular microtubule-dependent transport of incoming viral capsid. Interacts with the shutoff protein; this interaction allows folding and formation of hexons trimers. Interacts with pre-protein VI; this interaction probably allows nuclear import of hexon trimers and possibly pre-capsid assembly.
Subcellular location Virion. Host nucleus. Note=Forms the capsid icosahedric shell. Present in 720 copies per virion, assembled in 240 trimers.
Induction Expressed in the late phase of the viral replicative cycle.
Miscellaneous All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Similarity Belongs to the adenoviridae hexon protein family.

Keywords [?]

case <FTTag:Acet>
end case

Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0039623; Cellular component: T=25 icosahedral viral capsid.
GO:0019028; Cellular component: viral capsid.
GO:0005198; Molecular function: structural molecule activity.
GO:0075521; Biological process: microtubule-dependent intracellular transport of viral material towards nucleus.
GO:0046718; Biological process: viral entry into host cell.

Cross-references [?]

Pfam PF01065; Adeno_hexon; 1;
PF03678; Adeno_hexon_C; 1;

Features [?]

From: CAPSH_ADE05 (P04133)
Key     From     To       Description   Tag   Condition   FTGroup
INIT_MET     1     1       Removed; by host     M   1
case <FTGroup:1>
CHAIN     2     Cter       Hexon protein        
end case
case not <FTGroup:1>
CHAIN     Nter     Cter       Hexon protein        
end case
SITE     777     777       Involved in interaction with pre-protein VI     G  
MOD_RES     2     2       N-acetylalanine; by host   Acet   A  
MOD_RES     175     175       Phosphoserine; by host     S  
MOD_RES     940     940       Phosphotyrosine; by host     Y  

Additional information [?]

Size range 905-968 amino acids
Related rules None
Fusion None