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HAMAP rule MF_04051

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General rule information [?]

Accession MF_04051
Dates 9-MAR-2017 (Created)
20-NOV-2019 (Last updated, Version 4)
Scope(s) Viruses
Template(s) P04133 (CAPSH_ADE05); [ Recover all ]
Triggered by HAMAP; MF_04051 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CAPSH
Protein name RecName: Full=Hexon protein;
AltName: Full=Protein II;
Gene name Name=L3;

Comments [?]

FUNCTIONMajor capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.
SUBUNITHomotrimer. Interacts with the capsid vertex protein; this interaction binds the peripentonal hexons to the neighboring penton base. Interacts with the hexon-linking protein; this interaction tethers the hexons surrounding the penton to those situated in the central plate of the facet. Interacts with the hexon-interlacing protein; this interaction lashes the hexons together. Interacts with host dyneins DYNC1LI1 and DYNC1I2; this interaction might be involved in intracellular microtubule-dependent transport of incoming viral capsid. Interacts with the shutoff protein; this interaction allows folding and formation of hexons trimers. Interacts with pre-protein VI; this interaction probably allows nuclear import of hexon trimers and possibly pre-capsid assembly.
SUBCELLULAR LOCATIONVirion. Host nucleus. Note=Forms the capsid icosahedric shell. Present in 720 copies per virion, assembled in 240 trimers.
INDUCTIONExpressed in the late phase of the viral replicative cycle.
MISCELLANEOUSAll late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
SIMILARITYBelongs to the adenoviridae hexon protein family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus
GO:0039623; Cellular component:T=25 icosahedral viral capsid
GO:0019028; Cellular component:viral capsid
GO:0005198; Molecular function:structural molecule activity
GO:0075521; Biological process:microtubule-dependent intracellular transport of viral material towards nucleus
GO:0046718; Biological process:viral entry into host cell

Cross-references [?]

Pfam PF01065; Adeno_hexon; 1;
Pfam PF03678; Adeno_hexon_C; 1;

Features [?]

From: CAPSH_ADE05 (P04133)
Key From To Description Tag Condition FTGroup
INIT_MET 1 1 /note="Removed; by host" M 1
case <FTGroup:1>
CHAIN 2 Cter /note="Hexon protein"
end case
case not <FTGroup:1>
CHAIN Nter Cter /note="Hexon protein"
end case
SITE 777 777 /note="Involved in interaction with pre-protein VI" G
MOD_RES 2 2 /note="N-acetylalanine; by host" Acet A
MOD_RES 175 175 /note="Phosphoserine; by host" S
MOD_RES 940 940 /note="Phosphotyrosine; by host" Y

Additional information [?]

Size range 905-968 amino acids
Related rules None
Fusion Nter: None Cter: None

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