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Annotation rule MF_04069
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General rule information [?]

Accession MF_04069
Dates 11-APR-2017 (Created)
20-NOV-2019 (Last updated, Version 5)
Name INFV_M2
Viruses; Orthomyxoviridae
Template P06821 (M2_I34A1)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Matrix protein 2;
AltName: Full=Proton channel protein M2;
Gene name

Comments [?]

Function Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
Subunit Homotetramer; composed of two disulfide-linked dimers held together by non-covalent interactions. May interact with matrix protein 1.
Subcellular location Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Domain Cytoplasmic tail plays an important role in virion assembly and morphogenesis.
Miscellaneous When the channel is activated, one or more imidazole moities of #{His-37} probably become bi-protonated.
Similarity Belongs to the influenza viruses matrix protein M2 family.

Keywords [?]

case <FTTag:Carbo>
end case

Gene Ontology [?]

GO:0020002; Cellular component: host cell plasma membrane.
GO:0016021; Cellular component: integral component of membrane.
GO:0044385; Cellular component: integral to membrane of host cell.
GO:0055036; Cellular component: virion membrane.
GO:0015078; Molecular function: proton transmembrane transporter activity.
GO:0005216; Molecular function: ion channel activity.
GO:0039707; Biological process: pore formation by virus in membrane of host cell.
GO:0051259; Biological process: protein complex oligomerization.
GO:0039521; Biological process: suppression by virus of host autophagy.

Cross-references [?]

Pfam PF00599; Flu_M2; 1;

Computed features [?]

General Transmembrane; -; 1;

Features [?]

From: M2_I34A1 (P06821)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     22       Virion surface        
TRANSMEM     23     43       Helical; Signal-anchor for type III membrane protein        
TOPO_DOM     44     Cter       Intravirion        
SITE     37     37       Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter     H  
SITE     41     41       Seems to be involved in pH gating     W  
MOD_RES     64     64       Phosphoserine; by host     S  
MOD_RES     82     82       Phosphoserine; by host     S  
MOD_RES     93     93       Phosphoserine; by host     S  
LIPID     50     50       S-palmitoyl cysteine; by host     C  
CARBOHYD (Optional)     20     20       N-linked (GlcNAc...) asparagine; by host   Carbo   N  
DISULFID     17     17       Interchain (with #{Cys-17})     C  
DISULFID     19     19       Interchain (with #{Cys-19})     C  

Additional information [?]

Size range 96-100 amino acids
Related rules None
Fusion None