HAMAP rule MF_04074
General rule information
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| Accession | MF_04074 |
| Dates | 9-MAY-2017 (Created)
28-JUL-2023 (Last updated, Version 7) |
| Name | HBV_X |
| Scope(s) |
Viruses Orthohepadnavirus |
| Template(s) | Q69027 (X_HBVCJ); [ Recover all ] |
| Triggered by |
HAMAP; MF_04074 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | X |
| Protein name | RecName: Full=Protein X; AltName: Full=HBx; AltName: Full=Peptide X; AltName: Full=pX; |
| Gene name | Name=X; |
Comments
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| FUNCTION | Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC). Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation. This host complex would otherwise bind to viral episomal DNA, and prevents its transcription. Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. |
| SUBUNIT | May form homodimer. May interact with host CEBPA, CFLAR, CREB1, DDB1, E4F1, HBXIP, HSPD1/HSP60, NFKBIA, POLR2E and SMAD4. Interacts with host SMC5-SMC6 complex and induces its degradation. |
| SUBCELLULAR LOCATION | Host cytoplasm. Host nucleus. Host mitochondrion. Note=Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes. |
| PTM | A fraction may be phosphorylated in insect cells and HepG2 cells, a human hepatoblastoma cell line. Phosphorylated in vitro by host protein kinase C or mitogen-activated protein kinase. N-acetylated in insect cells. |
| SIMILARITY | Belongs to the orthohepadnavirus protein X family. |
Keywords
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Gene Ontology
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| GO:0033650; Cellular component:host cell mitochondrion |
| GO:0042025; Cellular component:host cell nucleus |
| GO:0039652; Biological process:induction by virus of host NF-kappaB cascade |
| GO:0039592; Biological process:perturbation by virus of G2/M transition of host mitotic cell cycle |
| GO:0006351; Biological process:DNA-templated transcription |
| GO:0019079; Biological process:viral genome replication |
Cross-references
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| Pfam | PF00739; X; 1; |
Features
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| From: X_HBVCJ (Q69027) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 68 | 117 | /note="Mitochondrial targeting sequence" | |||||||||
Additional information
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| Size range | 134-154 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |