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| Annotation rule MF_04076 |
General rule information
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| Accession | MF_04076 |
| Dates | 15-MAY-2017 (Created) 24-JAN-2020 (Last updated, Version 5) |
| Name | HBV_HBEAG |
| Scope | Viruses; Orthohepadnavirus |
| Templates | P0C767 (HBEAG_HBVCJ); Q76R61 (CAPSD_HBVCJ): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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case <FTTag:HBEAG>
| Identifier |
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| Protein name |
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| Gene name |
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else
| Identifier |
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| Protein name |
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| Gene name |
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end case
Comments
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case <FTTag:HBEAG>
| Function | May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells. This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections. |
| Subunit | Homodimerizes. |
| Subcellular location | Secreted. Host nucleus. |
| Ptm | Phosphorylated. |
| Cleaved by host furin. | |
| Similarity | Belongs to the orthohepadnavirus precore antigen family. |
else
| Function | Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with a icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions. |
| Encapsidates hepatitis delta genome. | |
| Subunit | Homodimerizes, then multimerizes. Interacts with cytosol exposed regions of viral L glycoprotein present in the reticulum-to-Golgi compartment. Interacts with human FLNB. Phosphorylated form interacts with host importin alpha; this interaction depends on the exposure of the NLS, which itself depends upon genome maturation and/or phosphorylation of the capsid protein. Interacts with host NUP153. |
| Subcellular location | Virion. Host cytoplasm. |
| Ptm | Phosphorylated by host SRPK1, SRPK2, and maybe protein kinase C or GAPDH. Phosphorylation is critical for pregenomic RNA packaging. Protein kinase C phosphorylation is stimulated by HBx protein and may play a role in transport of the viral genome to the nucleus at the late step during viral replication cycle. |
| Similarity | Belongs to the orthohepadnavirus core antigen family. |
end case
Keywords
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case <FTTag:HBEAG>
else
Capsid protein
Cytoplasmic inwards viral transport
DNA-binding
Host cytoplasm
Microtubular inwards viral transport
Phosphoprotein
RNA-binding
T=4 icosahedral capsid protein
Viral penetration into host nucleus
Virion
Virus entry into host cell
Cytoplasmic inwards viral transport
DNA-binding
Host cytoplasm
Microtubular inwards viral transport
Phosphoprotein
RNA-binding
T=4 icosahedral capsid protein
Viral penetration into host nucleus
Virion
Virus entry into host cell
end case
Gene Ontology
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case <FTTag:HBEAG>
GO:0005576; Cellular component: extracellular region.
GO:0042025; Cellular component: host cell nucleus.
GO:0030683; Biological process: mitigation of host immune response by virus.
GO:0042025; Cellular component: host cell nucleus.
GO:0030683; Biological process: mitigation of host immune response by virus.
else
GO:0030430; Cellular component: host cell cytoplasm.
GO:0039619; Cellular component: T=4 icosahedral viral capsid.
GO:0003677; Molecular function: DNA binding.
GO:0003723; Molecular function: RNA binding.
GO:0075521; Biological process: microtubule-dependent intracellular transport of viral material towards nucleus.
GO:0009405; Biological process: pathogenesis.
GO:0046718; Biological process: viral entry into host cell.
GO:0075732; Biological process: viral penetration into host nucleus.
GO:0039619; Cellular component: T=4 icosahedral viral capsid.
GO:0003677; Molecular function: DNA binding.
GO:0003723; Molecular function: RNA binding.
GO:0075521; Biological process: microtubule-dependent intracellular transport of viral material towards nucleus.
GO:0009405; Biological process: pathogenesis.
GO:0046718; Biological process: viral entry into host cell.
GO:0075732; Biological process: viral penetration into host nucleus.
end case
GO:0005198; Molecular function: structural molecule activity.
Cross-references
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Computed features
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case <FTTag:HBEAG>
| General | Signal; -; 1; trigger=yes; |
end case
Features
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| From: HBEAG_HBVCJ (P0C767) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 25 | 27 | HBEAG | HBEAG | G-W-L | |||||||
case <FTTag:HBEAG>
else
| From: CAPSD_HBVCJ (Q76R61) | ||||||||||||
| REGION | 177 | 183 | RNA binding | |||||||||
| MOTIF | 158 | 175 | Bipartite nuclear localization signal | |||||||||
| MOD_RES | 155 | 155 | Phosphoserine; by host | S | ||||||||
| MOD_RES | 162 | 162 | Phosphoserine; by host | S | ||||||||
| MOD_RES | 170 | 170 | Phosphoserine; by host | S | ||||||||
end case
Additional information
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| Size range | 182-218 amino acids |
| Related rules | None |
| Fusion | None |