HAMAP rule MF_04088
General rule information
[?]
| PURL | https://purl.expasy.org/hamap/rule/MF_04088 |
| Accession | MF_04088 |
| Dates | 8-FEB-2018 (Created)
1-MAR-2024 (Last updated, Version 5) |
| Name | ROTA_NSP1 |
| Scope(s) |
Viruses Rotavirus |
| Template(s) | Q99FX5 (NSP1_ROTS4); Q84940 (NSP1_ROTP5); [ Recover all ] |
| Triggered by |
HAMAP; MF_04088 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | NSP1 |
| Protein name | RecName: Full=Non-structural protein 1; Short=NSP1; AltName: Full=NCVP2; AltName: Full=Non-structural RNA-binding protein 53; Short=NS53; |
Comments
[?]
| case <FTTag:ILD> | |
| FUNCTION | Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities. Recognizes the host NF-kappa-B regulator BTRC through the presence of a DSGXS motif in the C-terminal substrate recognition domain. |
| SUBUNIT | Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation. Interacts with host CUL1 and CUL3. Interacts with host BTRC. |
| SUBCELLULAR LOCATION | Host cytoplasm, host cytoskeleton. |
| DOMAIN | The integrity of the zinc-binding domain in NSP1 is important for degradation of host IRF3. |
| PTM | The C-terminal region is phosphorylated by host CKII/CSNK2A1. Phosphorylation of the DSGXS motif is essential for host NF-kappa-B inhibition. |
| else | |
| FUNCTION | Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities. |
| SUBUNIT | Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation. Interacts with host CUL1 and CUL3. |
| SUBCELLULAR LOCATION | Host cytoplasm, host cytoskeleton. |
| DOMAIN | The integrity of the zinc-binding domain in NSP1 is important for degradation of host IRF3. |
| end case | |
| SIMILARITY | Belongs to the rotavirus NSP1 family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0030430; Cellular component:host cell cytoplasm | |
| GO:0044163; Cellular component:host cytoskeleton | |
| GO:0046872; Molecular function:metal ion binding | |
| GO:0003723; Molecular function:RNA binding | |
| GO:0039548; Biological process:symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity | |
| GO:0039557; Biological process:symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity | |
| case <FTTag:ILD> | |
| GO:0085034; Biological process:symbiont-mediated suppression of host NF-kappaB cascade | |
| end case | |
Cross-references
[?]
| Pfam | PF00981; Rota_NS53; 1; |
Features
[?]
| From: NSP1_ROTS4 (Q99FX5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 1 | 81 | /note="RNA-binding" | |||||||||
| REGION | 82 | 177 | /note="Important for cytoskeleton localization" | |||||||||
| From: NSP1_ROTP5 (Q84940) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 42 | 79 | /note="Zinc-binding domain" | |||||||||
| REGION | 317 | Cter | /note="Interaction with host IRF3" | |||||||||
| MOTIF | 479 | 483 | /note="IKBKB-like degron (ILD) motif" | ILD | D-S-G-x-S | |||||||
Additional information
[?]
| Size range | 393-496 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |