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HAMAP rule MF_04088

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General rule information [?]

Accession MF_04088
Dates 8-FEB-2018 (Created)
28-OCT-2021 (Last updated, Version 4)
Name ROTA_NSP1
Scope
Viruses; Rotavirus
Templates Q99FX5 (NSP1_ROTS4); Q84940 (NSP1_ROTP5): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NSP1
Protein name
RecName: Full=Non-structural protein 1;
Short=NSP1;
AltName: Full=NCVP2;
AltName: Full=Non-structural RNA-binding protein 53;
Short=NS53;

Comments [?]

case <FTTag:ILD>
Function Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities. Recognizes the host NF-kappa-B regulator BTRC through the presence of a DSGXS motif in the C-terminal substrate recognition domain.
Subunit Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation. Interacts with host CUL1 and CUL3. Interacts with host BTRC.
Subcellular location Host cytoplasm, host cytoskeleton.
Domain The integrity of the zinc-binding domain in NSP1 is important for degradation of host IRF3.
Ptm The C-terminal region is phosphorylated by host CKII/CSNK2A1. Phosphorylation of the DSGXS motif is essential for host NF-kappa-B inhibition.
else
Function Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.
Subunit Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation. Interacts with host CUL1 and CUL3.
Subcellular location Host cytoplasm, host cytoskeleton.
Domain The integrity of the zinc-binding domain in NSP1 is important for degradation of host IRF3.
end case
Similarity Belongs to the rotavirus NSP1 family.

Keywords [?]

Host cytoplasm
Host cytoskeleton
Host-virus interaction
Inhibition of host innate immune response by virus
Inhibition of host IRF3 by virus
Inhibition of host IRF7 by virus
case <FTTag:ILD>
Phosphoprotein
Inhibition of host NF-kappa-B by virus
end case
Inhibition of host RLR pathway by virus
Interferon antiviral system evasion
Metal-binding
RNA-binding
Viral immunoevasion

Gene Ontology [?]

GO:0030430; Cellular component: host cell cytoplasm.
GO:0044163; Cellular component: host cytoskeleton.
GO:0046872; Molecular function: metal ion binding.
GO:0003723; Molecular function: RNA binding.
GO:0039548; Biological process: suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity.
GO:0039557; Biological process: suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity.
case <FTTag:ILD>
GO:0039644; Biological process: suppression by virus of host NF-kappaB cascade.
end case

Cross-references [?]

Pfam PF00981; Rota_NS53; 1;

Features [?]

From: NSP1_ROTS4 (Q99FX5)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     1     81       RNA-binding        
REGION     82     177       Important for cytoskeleton localization        
From: NSP1_ROTP5 (Q84940)
REGION     42     79       Zinc-binding domain        
REGION     317     Cter       Interaction with host IRF3        
MOTIF     479     483       IKBKB-like degron (ILD) motif   ILD   D-S-G-x-S  

Additional information [?]

Size range 393-496 amino acids
Related rules None
Fusion None


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