HAMAP rule MF_04092
General rule information
[?]
Accession | MF_04092 |
Dates | 2-MAR-2018 (Created) 19-NOV-2022 (Last updated, Version 7) |
Name | ROTA_NSP5 |
Scope | Viruses; Rotavirus |
Template | A2T3Q9 (NSP5_ROTSH) |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
Protein name |
|
Comments
[?]
Function | Plays an essential role in the viral genome replication. Participates, together with NSP2, in the formation of viral factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place. Orchestrates the recruitment of viroplasmic proteins such as capsid proteins to these factories. |
case <FTTag:Metal>
Cofactor | Mg(2+) |
end case
case <FTGroup:1>
Subunit | Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to up-regulation of NSP5 hyperphosphorylation and formation of virus factories. Interacts with NSP6. |
else
Subunit | Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2 and NSP6. |
end case
Subcellular location | Host cytoplasm. Note=Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging. |
Ptm | O-glycosylated. |
case <FTGroup:1>
Ptm | Hyperphosphorylated on serine residues, when in dimeric form. Phosphorylation by host CK1 is required for the hyperphosphorylation of NSP5 dimer. |
end case
Similarity | Belongs to the rotavirus NSP5 family. |
Keywords
[?]
case <FTTag:Metal>
end case
case <FTGroup:1>
end case
Gene Ontology
[?]
GO:0030430; Cellular component: host cell cytoplasm.
GO:0016887; Molecular function: ATP hydrolysis activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0000166; Molecular function: nucleotide binding.
GO:0003723; Molecular function: RNA binding.
GO:0019079; Biological process: viral genome replication.
GO:0016887; Molecular function: ATP hydrolysis activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0000166; Molecular function: nucleotide binding.
GO:0003723; Molecular function: RNA binding.
GO:0019079; Biological process: viral genome replication.
Cross-references
[?]
Pfam | PF01525; Rota_NS26; 1; |
PF17580; GBR_NSP5; 1; | |
PIRSF | PIRSF004006; Rota_NS26; 1; |
Features
[?]
From: NSP5_ROTSH (A2T3Q9) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 92 | 92 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | Metal | D | |||||||
MOD_RES | 67 | 67 | Phosphoserine; by host CK1 | S | 1 | |||||||
MOD_RES | 154 | 154 | Phosphoserine; by host | S | 1 | |||||||
MOD_RES | 156 | 156 | Phosphoserine; by host | S | 1 | |||||||
MOD_RES | 164 | 164 | Phosphoserine; by host | S | 1 | |||||||
MOD_RES | 166 | 166 | Phosphoserine; by host | S | 1 |
Additional information
[?]
Size range | 170-212 amino acids |
Related rules | None |
Fusion | None |