HAMAP rule MF_04095

General rule information [?]

Accession	MF_04095
Dates	19-MAR-2018 (Created) 20-NOV-2019 (Last updated, Version 3)

Name	ALPHA_CORONA_NCAP

Scope

Viruses; Coronavirinae

Template

P04134 (NCAP_CVPPU)

Triggered by

HAMAP; MF_04095 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

NCAP

Protein name

RecName:		Full=Nucleoprotein;
AltName:		Full=Nucleocapsid protein;
		Short=NC;
		Short=Protein N;

Gene name

Comments [?]

Function	Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
Subunit	Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.
Subcellular location	Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Ptm	ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.
	Phosphorylated on serine and threonine residues.
Similarity	Belongs to the alphacoronavirus nucleocapsid protein family.

Keywords [?]

ADP-ribosylation
Host Golgi apparatus
Phosphoprotein
Ribonucleoprotein
RNA-binding
Transcription
Transcription regulation
Viral nucleoprotein
Virion

Gene Ontology [?]

GO:0044172; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment.
GO:0044177; Cellular component: host cell Golgi apparatus.
GO:0019013; Cellular component: viral nucleocapsid.
GO:0003723; Molecular function: RNA binding.

Cross-references [?]

Pfam	PF00937; Corona_nucleoca; 1;
PIRSF	PIRSF003888; Corona_nucleocap; 1;

Features [?]

From: NCAP_CVPPU (P04134)

Key From To Description Tag Condition FTGroup

REGION 33 159 RNA-binding

REGION 231 334 Dimerization

MOD_RES 9 9 Phosphoserine; by host S

MOD_RES 156 156 Phosphoserine; by host S

MOD_RES 254 254 Phosphoserine; by host S

MOD_RES 256 256 Phosphoserine; by host S

Additional information [?]

Size range	377-441 amino acids
Related rules	None
Fusion	None

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