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HAMAP rule MF_04095

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General rule information [?]

Accession MF_04095
Dates 19-MAR-2018 (Created)
20-NOV-2019 (Last updated, Version 3)
Viruses; Coronavirinae
Template P04134 (NCAP_CVPPU)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Nucleoprotein;
AltName: Full=Nucleocapsid protein;
Short=Protein N;
Gene name

Comments [?]

Function Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
Subunit Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.
Subcellular location Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Ptm ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.
Phosphorylated on serine and threonine residues.
Similarity Belongs to the alphacoronavirus nucleocapsid protein family.

Keywords [?]

Gene Ontology [?]

GO:0044172; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment.
GO:0044177; Cellular component: host cell Golgi apparatus.
GO:0019013; Cellular component: viral nucleocapsid.
GO:0003723; Molecular function: RNA binding.

Cross-references [?]

Pfam PF00937; Corona_nucleoca; 1;
PIRSF PIRSF003888; Corona_nucleocap; 1;

Features [?]

From: NCAP_CVPPU (P04134)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     33     159       RNA-binding        
REGION     231     334       Dimerization        
MOD_RES     9     9       Phosphoserine; by host     S  
MOD_RES     156     156       Phosphoserine; by host     S  
MOD_RES     254     254       Phosphoserine; by host     S  
MOD_RES     256     256       Phosphoserine; by host     S  

Additional information [?]

Size range 377-441 amino acids
Related rules None
Fusion None