HAMAP rule MF_04097

General rule information [?]

Accession	MF_04097
Dates	19-MAR-2018 (Created) 19-MAR-2021 (Last updated, Version 4)

Name	GAMMA_CORONA_NCAP

Scope

Viruses; Gammacoronavirus

Template

P69596 (NCAP_IBVB)

Triggered by

HAMAP; MF_04097 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

NCAP

Protein name

RecName:		Full=Nucleoprotein;
AltName:		Full=Nucleocapsid protein;
		Short=NC;
		Short=Protein N;

Gene name

Comments [?]

Function	Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
Subunit	Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.
Subcellular location	Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Ptm	ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.
	Phosphorylated on serine and threonine residues.
Similarity	Belongs to the gammacoronavirus nucleocapsid protein family.

Keywords [?]

ADP-ribosylation
Disulfide bond
Host Golgi apparatus
Phosphoprotein
Ribonucleoprotein
RNA-binding
Transcription
Transcription regulation
Viral nucleoprotein
Virion

Gene Ontology [?]

GO:0044172; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment.
GO:0044177; Cellular component: host cell Golgi apparatus.
GO:0019013; Cellular component: viral nucleocapsid.
GO:0003723; Molecular function: RNA binding.

Cross-references [?]

Pfam	PF00937; Corona_nucleoca; 1;
PIRSF	PIRSF003888; Corona_nucleocap; 1;

Features [?]

From: NCAP_IBVB (P69596)

Key From To Description Tag Condition FTGroup

REGION 29 160 RNA-binding

REGION 226 333 Dimerization

MOD_RES 190 190 Phosphoserine; by host S

MOD_RES 192 192 Phosphoserine; by host S

MOD_RES 378 378 Phosphothreonine; by host T

MOD_RES 379 379 Phosphoserine; by host S

DISULFID 281 308 C-x*-C

DISULFID 320 323 C-x*-C

Additional information [?]

Size range	409-409 amino acids
Related rules	None
Fusion	None

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