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HAMAP rule MF_04097

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General rule information [?]

Accession MF_04097
Dates 19-MAR-2018 (Created)
19-MAR-2021 (Last updated, Version 4)
Viruses; Gammacoronavirus
Template P69596 (NCAP_IBVB)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Nucleoprotein;
AltName: Full=Nucleocapsid protein;
Short=Protein N;
Gene name

Comments [?]

Function Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
Subunit Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.
Subcellular location Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Ptm ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.
Phosphorylated on serine and threonine residues.
Similarity Belongs to the gammacoronavirus nucleocapsid protein family.

Keywords [?]

Gene Ontology [?]

GO:0044172; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment.
GO:0044177; Cellular component: host cell Golgi apparatus.
GO:0019013; Cellular component: viral nucleocapsid.
GO:0003723; Molecular function: RNA binding.

Cross-references [?]

Pfam PF00937; Corona_nucleoca; 1;
PIRSF PIRSF003888; Corona_nucleocap; 1;

Features [?]

From: NCAP_IBVB (P69596)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     29     160       RNA-binding        
REGION     226     333       Dimerization        
MOD_RES     190     190       Phosphoserine; by host     S  
MOD_RES     192     192       Phosphoserine; by host     S  
MOD_RES     378     378       Phosphothreonine; by host     T  
MOD_RES     379     379       Phosphoserine; by host     S  
DISULFID     281     308             C-x*-C  
DISULFID     320     323             C-x*-C  

Additional information [?]

Size range 409-409 amino acids
Related rules None
Fusion None