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HAMAP rule MF_04126

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General rule information [?]

Accession MF_04126
Dates 28-MAR-2018 (Created)
20-NOV-2019 (Last updated, Version 3)
Name Rota_VP6
Scope(s) Viruses
Template(s) P04509 (VP6_ROTRF); A2T3T0 (VP6_ROTSH); P18610 (VP6_ROTBU); Q91N61 (VP6_ROTP5); [ Recover all ]
Triggered by HAMAP; MF_04126 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier VP6
Protein name RecName: Full=Intermediate capsid protein VP6;

Comments [?]

FUNCTIONIntermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP.
SUBCELLULAR LOCATIONVirion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
SUBUNITHomotrimer. Interacts with the inner capsid protein VP2. Interacts with the outer capsid glycoprotein VP7.
SIMILARITYBelongs to the rotavirus VP6 family.

Keywords [?]

Gene Ontology [?]

GO:0019031; Cellular component:viral envelope
GO:0039626; Cellular component:viral intermediate capsid
GO:0046789; Molecular function:host cell surface receptor binding
GO:0005198; Molecular function:structural molecule activity
GO:0019064; Biological process:fusion of virus membrane with host plasma membrane

Cross-references [?]

Pfam PF00980; Rota_Capsid_VP6; 1;

Features [?]

Additional information [?]

Size range 390-400 amino acids
Related rules MF_04129
Fusion Nter: None Cter: None

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