HAMAP rule MF_04126

General rule information [?]

Accession	MF_04126
Dates	28-MAR-2018 (Created) 20-NOV-2019 (Last updated, Version 3)
Name	Rota_VP6
Scope(s)	Viruses Rotavirus
Template(s)	P04509 (VP6_ROTRF); A2T3T0 (VP6_ROTSH); P18610 (VP6_ROTBU); Q91N61 (VP6_ROTP5); [ Recover all ]
Triggered by	HAMAP; MF_04126 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	VP6
Protein name	RecName: Full=Intermediate capsid protein VP6;

Comments [?]

FUNCTION	Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP.
SUBCELLULAR LOCATION	Virion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
SUBUNIT	Homotrimer. Interacts with the inner capsid protein VP2. Interacts with the outer capsid glycoprotein VP7.
SIMILARITY	Belongs to the rotavirus VP6 family.

Keywords [?]

Gene Ontology [?]

GO:0019031; Cellular component:viral envelope

GO:0039626; Cellular component:viral intermediate capsid

GO:0046789; Molecular function:host cell surface receptor binding

GO:0005198; Molecular function:structural molecule activity

GO:0019064; Biological process:fusion of virus membrane with host plasma membrane

Cross-references [?]

Pfam	PF00980; Rota_Capsid_VP6; 1;

Features [?]

Additional information [?]