HAMAP rule MF_04126
General rule information
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| Accession | MF_04126 |
| Dates | 28-MAR-2018 (Created) 20-NOV-2019 (Last updated, Version 3) |
| Name | Rota_VP6 |
| Scope | Viruses; Rotavirus |
| Templates | P04509 (VP6_ROTRF); A2T3T0 (VP6_ROTSH); P18610 (VP6_ROTBU); Q91N61 (VP6_ROTP5): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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Comments
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| Function | Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP. |
| Subcellular location | Virion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging. |
| Subunit | Homotrimer. Interacts with the inner capsid protein VP2. Interacts with the outer capsid glycoprotein VP7. |
| Similarity | Belongs to the rotavirus VP6 family. |
Keywords
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Gene Ontology
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GO:0019031; Cellular component: viral envelope.
GO:0039626; Cellular component: viral intermediate capsid.
GO:0046789; Molecular function: host cell surface receptor binding.
GO:0005198; Molecular function: structural molecule activity.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
GO:0039626; Cellular component: viral intermediate capsid.
GO:0046789; Molecular function: host cell surface receptor binding.
GO:0005198; Molecular function: structural molecule activity.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
Cross-references
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| Pfam | PF00980; Rota_Capsid_VP6; 1; |
Additional information
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| Size range | 390-400 amino acids |
| Related rules | MF_04129 (VP6 supersedes the current rule) |
| Fusion | None |