HAMAP rule MF_04142
General rule information
[?]
| Accession | MF_04142 |
| Dates | 8-OCT-2019 (Created)
2-SEP-2024 (Last updated, Version 13) |
| Name | MODB_T4 |
| Scope(s) |
Viruses Tevenvirinae |
| Template(s) | P39423 (MODB_BPT4); [ Recover all ] |
| Triggered by |
HAMAP; MF_04142 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | MODB |
| Protein name | RecName: Full=NAD--protein ADP-ribosyltransferase modB; EC=2.4.2.31; |
| Gene name | Name=modB; |
Comments
[?]
| FUNCTION | ADP-ribosyltransferase that regulates transcription by ADP- ribosylation of host ribosomal protein S1. Additional identified targets include proteins involved in either translation or cellular metabolism such as elongation factor-Tu or trigger factor. Also reprograms the host's gene-expression system by RNAylating host ribosomal protein S1. ModB can attach NAD-capped RNAs to target proteins post-transcriptionally resulting in covalent RNA-protein conjugates. |
| CATALYTIC ACTIVITY | Reaction=L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L- arginyl-[protein] + nicotinamide + H(+); Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=2.4.2.31; |
| SUBCELLULAR LOCATION | Virion. Note=This protein is injected from the virion into the bacterial cell. |
| SIMILARITY | Belongs to the Tevenvirinae NAD--protein ADP- ribosyltransferase modA family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0106274; Molecular function:NAD+-protein-arginine ADP-ribosyltransferase activity |
| GO:0044423; Cellular component:virion component |
Cross-references
[?]
Features
[?]
| From: MODB_BPT4 (P39423) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 173 | 173 | E | |||||||||
| BINDING | 73 | 73 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
R | ||||||||
Additional information
[?]
| Size range | 185-240 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |