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Annotation rule MF_04166
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General rule information [?]

Accession MF_04166
Dates 3-JUN-2021 (Created)
9-JUN-2021 (Last updated, Version 2)
Name Phage_PURZ
Viruses; Caudovirales
Template G3FFN6 (PURZ_BPVC8)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=N6-succino-2-amino-2'-deoxyadenylate synthase;
AltName: Full=PurZ;
Gene name

Comments [?]

Function Involved in the synthesis of the atypical nucleotide dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate). Involved in the synthesis of N6-succino-2-amino-2'-deoxyadenylate, which undergoes defumarylation and phosphorylation respectively by host PurB and guanylate/nucleoside diphosphate kinases to give dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate). dZTP is integrated into the viral genome instead of adenine by the viral polymerase. This Z-base probably completely replaces adenosine and forms a triple bond to the opposite T-base. The resulting non-standard viral DNA is called Z-genome. The chemically modified DNA is probably harder for the host bacteria to digest with nucleases or restriction enzymes.
Catalytic activity RHEA:67628: ATP + dGMP + L-aspartate = (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate
case <FTGroup:1>
Cofactor Mg(2+)
end case
Pathway Purine metabolism.
Similarity Belongs to the Caudovirales PurZ family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006164; Biological process: purine nucleotide biosynthetic process.

Cross-references [?]

Pfam PF00709; Adenylsucc_synt; 0-2;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     14     14             S  
METAL     14     14       Magnesium     S   1
METAL     42     42       Magnesium; via carbonyl oxygen     G   1
METAL     263     263       Magnesium     T   1
BINDING     262     262       Substrate     [AT]  
BINDING     264     264       Substrate; via carbonyl oxygen     V  
BINDING     269     269       Substrate     R  

Additional information [?]

Size range 320-420 amino acids
Related rules None
Fusion None