HAMAP rule MF_01132
General rule information
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| Accession | MF_01132 |
| Dates | 2-FEB-2004 (Created)
1-JUN-2023 (Last updated, Version 26) |
| Name | Spx |
| Scope(s) |
Bacteria Bacillota |
| Template(s) | O31602 (SPX_BACSU); Q2G1U6 (SPX_STAA8); [ Recover all ] |
| Triggered by |
HAMAP; MF_01132 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SPX |
| Protein name | RecName: Full=Global transcriptional regulator Spx; |
| Gene name | Name=spx; |
Comments
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| FUNCTION | Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP). This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator |
| SUBUNIT | Interacts with the C-terminal domain of the alpha subunit of the RNAP. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the ArsC family. Spx subfamily. |
Keywords
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| Cytoplasm | |
| case <FT:1> | |
| Disulfide bond | |
| Redox-active center | |
| end case | |
| Transcription | |
| Transcription regulation | |
Gene Ontology
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| GO:0006355; Biological process:regulation of DNA-templated transcription |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: SPX_BACSU (O31602) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DISULFID | 10 | 13 | /note="Redox-active" | C-x-x-C | ||||||||
Additional information
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| Size range | 128-160 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |