Annotation rule MF_01644
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General rule information [?]

Accession MF_01644
Dates 14-JAN-2008 (Created)
10-MAY-2017 (Last updated, Version 12)
Name D_hydantoinase
Scope Bacteria; Enterobacteriaceae
Template Q46806 (PHYDA_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=D-phenylhydantoinase;
AltName: Full=Hydantoin-utilizing enzyme HyuA;
Gene name

Comments [?]

Function Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is unknown.
Cofactor a divalent metal cation
Note: Binds 2 divalent metal cations per subunit.
Subunit Homotetramer.
Ptm Carbamylation allows a single lysine to coordinate two divalent metal cations.
Similarity Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

Keywords [?]

Gene Ontology [?]

GO:0016812; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides.

Cross-references [?]

Pfam PF01979; Amidohydro_1; 1;
TIGRFAMs TIGR02033; D-hydantoinase; 1;

Features [?]

From: PHYDA_ECOLI (Q46806)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     59     59       Divalent metal cation 1     H  
METAL     61     61       Divalent metal cation 1     H  
METAL     151     151       Divalent metal cation 1; via carbamate group     K  
METAL     151     151       Divalent metal cation 2; via carbamate group     K  
METAL     182     182       Divalent metal cation 2     H  
METAL     239     239       Divalent metal cation 2     H  
METAL     313     313       Divalent metal cation 1     D  
BINDING     156     156       Substrate     Y  
BINDING     286     286       Substrate; via amide nitrogen and carbonyl oxygen     S  
BINDING     335     335       Substrate; via carbonyl oxygen     N  
MOD_RES     151     151       N6-carboxylysine     K  

Additional information [?]

Size range 461-461 amino acids
Related rules None
Fusion None