HAMAP rule MF_00037
General rule information
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Accession | MF_00037 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 39) |
Name | MurB |
Scope(s) |
Bacteria |
Template(s) | P18579 (MURB_BACSU); P08373 (MURB_ECOLI); P61431 (MURB_STAAU); [ Recover all ] |
Triggered by |
HAMAP; MF_00037 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MURB |
Protein name | RecName: Full=UDP-N-acetylenolpyruvoylglucosamine reductase; EC=1.3.1.98; AltName: Full=UDP-N-acetylmuramate dehydrogenase; |
Gene name | Name=murB; |
Comments
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FUNCTION | Cell wall formation. |
CATALYTIC ACTIVITY | Reaction=NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP- N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine; Xref=Rhea:RHEA:12248, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:68483, ChEBI:CHEBI:70757; EC=1.3.1.98; |
COFACTOR | Name=FAD; Xref=ChEBI:CHEBI:57692; |
PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the MurB family. |
Keywords
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Cell cycle |
Cell division |
Cell shape |
Cell wall biogenesis/degradation |
Cytoplasm |
FAD |
Flavoprotein |
NADP |
Oxidoreductase |
Peptidoglycan synthesis |
Gene Ontology
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GO:0008762; Molecular function:UDP-N-acetylmuramate dehydrogenase activity |
GO:0009252; Biological process:peptidoglycan biosynthetic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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PROSITE | PS51387; FAD_PCMH; 1; |
Pfam | PF01565; FAD_binding_4; 1; |
Pfam | PF02873; MurB_C; 1; |
NCBIfam | TIGR00179; MurB; 1; |
Features
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From: MURB_ECOLI (P08373) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 159 | 159 | R | |||||||||
ACT_SITE | 229 | 229 | /note="Proton donor" | [CS] | ||||||||
ACT_SITE | 325 | 325 | E |
Additional information
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Size range | 258-383 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | Possible wrong start in NOSS1 and SYNY3. Divergent sequences in BIFLO and TREPA. |