HAMAP

Accession	MF_00130
Dates	1-JUN-2001 (Created) 16-MAY-2011 (Last updated, Version 20)

Data class

Protein

Predictors

HAMAP; MF_00130; [distribution of match scores in UniProtKB];[seed alignment for MF_00130]

Names

RecU

Identifier

RECU

Protein name

RecName: Full=Holliday junction resolvase recU; EC=3.1.22.-; AltName: Full=Recombination protein U homolog;

Gene name

recU

FUNCTION: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity).

COFACTOR: Binds 1 magnesium ion per subunit (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the recU family.

Pfam	PF03838; RecU; 1;
TIGRFAMs	TIGR00648; RecU; 1;

Cytoplasm, DNA damage, DNA repair, DNA recombination, Endonuclease, Hydrolase, Magnesium, Metal-binding, Nuclease.

GO:0004519; Molecular function: endonuclease activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0007059; Biological process: chromosome segregation.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.
GO:0005737; Cellular component: cytoplasm.

From: RECU_GEOKA (Q5KXY4)
Key		From		To		Description		Condition		FTGroup
METAL		84		84		Magnesium; via carbonyl oxygen (By similarity)		T
METAL		86		86		Magnesium (By similarity)		D
METAL		99		99		Magnesium (By similarity)		[DE]
METAL		118		118		Magnesium (By similarity)		Q
SITE		101		101		Transition state stabilizer (By similarity)		K

Size range:	157-213 amino acids
Related UniRules:	None
Template:	P39792 (RECU_BACSU); Q5KXY4 (RECU_GEOKA): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None